Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Paul V. Lehmann"'
Publikováno v:
Onco, Vol 4, Iss 2, Pp 68-76 (2024)
Synthetic peptides derived from antigen sequences are essential reagents for the detection of CD8+ cytotoxic T lymphocytes (CTLs), in assays such as ELISPOT/ImmunoSpot®. Indeed, the combination of peptides and ImmunoSpot® has been widely used for i
Externí odkaz:
https://doaj.org/article/df77fdd64f7d4caa89fe2270ba6f5f54
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Prediction of B cell epitopes that can replace the antigen for antibody production and detection is of great interest for research and the biotech industry. Here, we developed a novel BLAST-based method to predict linear B cell epitopes. To
Externí odkaz:
https://doaj.org/article/24f7732c169345bc82c60c0b96b83beb
Autor:
Carla Wolf, Sebastian Köppert, Noémi Becza, Stefanie Kuerten, Greg A. Kirchenbaum, Paul V. Lehmann
Publikováno v:
Cells, Vol 11, Iss 22, p 3662 (2022)
The scope of immune monitoring is to define the existence, magnitude, and quality of immune mechanisms operational in a host. In clinical trials and praxis, the assessment of humoral immunity is commonly confined to measurements of serum antibody rea
Externí odkaz:
https://doaj.org/article/66c522f5623244328dc7b28819b63dfe
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
SARS-CoV-2 infection takes a mild or clinically inapparent course in the majority of humans who contract this virus. After such individuals have cleared the virus, only the detection of SARS-CoV-2-specific immunological memory can reveal the exposure
Externí odkaz:
https://doaj.org/article/31fc35a5c5b040e09fa4216694f77efb
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
CD8+ T cell immune monitoring aims at measuring the size and functions of antigen-specific CD8+ T cell populations, thereby providing insights into cell-mediated immunity operational in a test subject. The selection of peptides for ex vivo CD8+ T cel
Externí odkaz:
https://doaj.org/article/c23c55a2c70e4c82b8441a412a14d402
Autor:
Sebastian Köppert, Carla Wolf, Noémi Becza, Giuseppe A. Sautto, Fridolin Franke, Stefanie Kuerten, Ted M. Ross, Paul V. Lehmann, Greg A. Kirchenbaum
Publikováno v:
Cells, Vol 10, Iss 8, p 1843 (2021)
Assessment of humoral immunity to SARS-CoV-2 and other infectious agents is typically restricted to detecting antigen-specific antibodies in the serum. Rarely does immune monitoring entail assessment of the memory B-cell compartment itself, although
Externí odkaz:
https://doaj.org/article/2d52a612e7df4b409f0ff525e621f667
Autor:
Paul V. Lehmann, Maneewan Suwansaard, Ting Zhang, Diana R. Roen, Greg A. Kirchenbaum, Alexey Y. Karulin, Alexander Lehmann, Pedro A. Reche
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
T cell immunity is traditionally assessed through functional recall assays, which detect the consequences of the T cells' antigen encounter, or via fluorescently labeled multimers that selectively bind peptide-specific T cell receptors. Using either
Externí odkaz:
https://doaj.org/article/082307207f73445d8689f2a80034651d
Publikováno v:
Cells, Vol 10, Iss 2, p 248 (2021)
Monitoring antigen-specific T cell immunity relies on functional tests that require T cells and antigen presenting cells to be uncompromised. Drawing of blood, its storage and shipment from the clinical site to the test laboratory, and the subsequent
Externí odkaz:
https://doaj.org/article/f59a7901f4914d44946308ead2536890
Publikováno v:
Computational Vaccine Design ISBN: 9781071632383
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a30ad2f8945fb6fcf9c7689d09c2ec4d
https://doi.org/10.1007/978-1-0716-3239-0_5
https://doi.org/10.1007/978-1-0716-3239-0_5
Publikováno v:
Cells, Vol 9, Iss 2, p 433 (2020)
Detection of antigen-specific memory B cells for immune monitoring requires their activation, and is commonly accomplished through stimulation with the TLR7/8 agonist R848 and IL-2. To this end, we evaluated whether addition of IL-21 would further en
Externí odkaz:
https://doaj.org/article/bad25a343a314c8992cf3a80f64c6212