Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Paul V Macrae"'
Autor:
Russell Jones, Paul V Macrae, Michelle Gleave, Christophe Chassaing, Patricia Wright, Kenneth Saunders, Nigel J. Cussans, Caroline E Green, Drew Gibson
Publikováno v:
Biomedical Chromatography. 20:585-596
Increased demand for assays for compounds at the early stages of drug discovery within the pharmaceutical industry has led to the need for open-access mass spectrometry systems for performing quantitative analysis in a variety of biological matrices.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07bfe5a65fe5d1b6ceee9b275540ade5
https://doi.org/10.1002/bmc.668
https://doi.org/10.1002/bmc.668
Publikováno v:
Journal of Chromatography B. 817:77-80
This communication describes the invention and further development of the first 96-well solid-phase extraction system and the original purposes to which it was put. We also describe the adaption of this system for bioanalysis of pharmaceutically acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22e174c1a9c46482b20497800c180e5b
https://doi.org/10.1016/j.jchromb.2004.08.029
https://doi.org/10.1016/j.jchromb.2004.08.029
Publikováno v:
Rapid Communications in Mass Spectrometry. 19:2005-2014
An observation that a series of proprietary compounds containing a methyl thiophenyl group all underwent metabolic S-oxidation, and that the product ion spectra of the resulting S-oxides showed methyl radical loss under low-energy atmospheric pressur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48be2c7ea6b47da7c7433814545c6934
https://doi.org/10.1002/rcm.2015
https://doi.org/10.1002/rcm.2015
Autor:
Richard F. Venn, Christophe Chassaing, Paul V Macrae, Patricia Wright, Kenneth Saunders, J. Luckwell
Publikováno v:
Chromatographia. 53:122-130
Turbulent flow chromatography coupled to tandem mass spectrometry (TFC-MS-MS) has recently emerged as a potentially fast, sensitive and specific technique for the direct analysis of pharmaceutical compounds from crude plasma. TFC-MS-MS removes the ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30e43b64a7d0f847104dffb983205ea5
https://doi.org/10.1007/bf02491558
https://doi.org/10.1007/bf02491558
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 16:883-892
Sampatrilat is a dual inhibitor of angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) under development for the treatment of hypertension and congestive heart failure. In order to support the early clinical development (with oral adm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60722d69eba79f761dcdfb7b646a107f
https://doi.org/10.1016/s0731-7085(97)00127-1
https://doi.org/10.1016/s0731-7085(97)00127-1
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 16:875-881
Sampatrilat is a dual inhibitor of angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) under development for the treatment of hypertension and congestive heart failure. In order to support the early clinical development (with oral adm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4826f7a5966fb02fb37a5797069dc7d7
https://doi.org/10.1016/s0731-7085(97)00126-x
https://doi.org/10.1016/s0731-7085(97)00126-x
Publikováno v:
Rapid Communications in Mass Spectrometry. 7:605-609
The utility of on-line liquid chromatogaphy coupled to UV diode array detection and atmospheric pressure chemical ionization mass spectrometry for the analysis of microsomal metabolites of felodipine has been investigated. A previously unreported met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f89e0ad69bebd06035541c39b11208e0
https://doi.org/10.1002/rcm.1290070710
https://doi.org/10.1002/rcm.1290070710
Rapid, Solid Phase Extraction Technique for the High-Throughput Assay of Darifenacin in Human Plasma
Autor:
Barry Kaye, D. A. Stopher, William J. Herron, Paul V Macrae, William Wild, Richard F. Venn, Sylvia Robinson
Publikováno v:
Analytical Chemistry. 68:1658-1660
A novel method has been developed for the rapid solid phase extraction of drugs and metabolites from biological fluids, prior to further analysis. The newly designed, 96-tube micropreparation block facilitates high throughput by enabling the extracti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbbbad76894aab04e6d40f677ce48aa
https://doi.org/10.1021/ac9507552
https://doi.org/10.1021/ac9507552
Publikováno v:
Biological mass spectrometry. 21(11)
A method is described for the determination of abanoquil in human blood. The method is based on high-performance liquid chromatography (HPLC)/atmospheric pressure positive ion chemical ionization mass spectrometry, using (2H3)abanoquil as internal st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91ff5c1b7e9601572e4d76d60a28527c
https://pubmed.ncbi.nlm.nih.gov/1360817
https://pubmed.ncbi.nlm.nih.gov/1360817
Publikováno v:
Journal of chromatography. 562(1-2)
The nonapeptide Val-Ser-Gln-Asn-Tyr-Pro-Ile-Val-Gln has been reported as a model substrate for an aspartyl protease produced by the human immunodeficiency virus (HIV-1). Cleavage of this peptide at the Tyr-Pro linkage to produce tetra- and pentapepti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::919bdfa3a1faeef68133d571f77180c7
https://pubmed.ncbi.nlm.nih.gov/2026729
https://pubmed.ncbi.nlm.nih.gov/2026729