Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Paul V, Fish"'
Autor:
Nicky J. Willis, Elliott D. Bayle, George Papageorgiou, David Steadman, Benjamin N. Atkinson, William Mahy, Paul V. Fish
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 15, Iss 1, Pp 2790-2797 (2019)
Background: The carboxylesterase Notum has been shown to act as a key negative regulator of the Wnt signalling pathway by mediating the depalmitoleoylation of Wnt proteins. LP-922056 (1) is an orally active inhibitor of Notum. We are investigating th
Externí odkaz:
https://doaj.org/article/0e99894a7cf64cf9a6e14cd7a002f112
Autor:
Peter Loppnau, Minkui Luo, Pegah Ghiabi, Albina Bolotokova, Irene Chau, Fengling Li, Jing Liu, Matthieu Schapira, Karla J. F. Satchell, Sumera Perveen, Ke Wang, Aliakbar Khalili Yazdi, Paul V. Fish, Jian Jin, Peter Brown, Deyao Li, Masoud Vedadi, David Smil, Kanchan Devkota, Taraneh Hajian
Publikováno v:
Slas Discovery
bioRxiv
bioRxiv
The COVID-19 pandemic has clearly brought the healthcare systems world-wide to a breaking point along with devastating socioeconomic consequences. The SARS-CoV-2 virus which causes the disease uses RNA capping to evade the human immune system. Non-st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a55059fd32681033cafc1474270f7838
http://europepmc.org/articles/PMC8458670
http://europepmc.org/articles/PMC8458670
Autor:
Benjamin N, Atkinson, Nicky J, Willis, Jennifer, Smith, Rebecca, Gill, Jody, Ali, Zhou, Xu, Ping-Shan, Lai, Paul V, Fish
Publikováno v:
RSC advances. 12(41)
1-Phenyl-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::30181eb9e0169a716f6a66ed1cd3f3de
https://pubmed.ncbi.nlm.nih.gov/36275171
https://pubmed.ncbi.nlm.nih.gov/36275171
Autor:
Benjamin N. Atkinson, Nicky J. Willis, Jennifer Smith, Rebecca Gill, Jody Ali, Zhou Xu, Ping-Shan Lai, Paul V. Fish
1-Phenyl-1H-1,2,3-triazole 1 (ARUK3001185) was prepared on large scale from aniline 4 by application of both (1) a copper catalyzed azide-alkyne cycloaddition (CuAAC) with (trimethylsilyl)acetylene, and (2) a Clark modification of the Sakai reaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faf0c4165b4fd2acdb0efbe7c2d45e04
https://doi.org/10.26434/chemrxiv-2022-4vzgh
https://doi.org/10.26434/chemrxiv-2022-4vzgh
Publikováno v:
Future Medicinal Chemistry
Notum has recently been identified as a negative regulator of Wnt signaling through the removal of an essential palmitoleate group from Wnt proteins. There are emerging reports that Notum plays a role in human disease, with published data suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::011800057396f511ca1a4ce9b2087607
https://doi.org/10.4155/fmc-2021-0036
https://doi.org/10.4155/fmc-2021-0036
Autor:
Benjamin N. Atkinson, Nicky J. Willis, Yuguang Zhao, Chandni Patel, Sarah Frew, Kathryn Costelloe, Lorenza Magno, Fredrik Svensson, E. Yvonne Jones, Paul V. Fish
Publikováno v:
European Journal of Medicinal Chemistry. 251:115132
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c67f2b178d0c6ac790dd98f0ff8ccd64
https://doi.org/10.1016/j.ejmech.2023.115132
https://doi.org/10.1016/j.ejmech.2023.115132
Autor:
Benjamin N. Atkinson, Fredrik Svensson, Hannah Woodward, Paul Whiting, Elliott D. Bayle, Paul V. Fish, Nicky J. Willis, Jean-Paul Vincent, David Steadman
Publikováno v:
Journal of Medicinal Chemistry
Regulation of the Wnt signaling pathway is critically important for a number of cellular processes in both development and adult mammalian biology. This Perspective will provide a summary of current and emerging therapeutic opportunities in modulatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1daca6a8ed39142ac3fc8a7145d74588
https://doi.org/10.1021/acs.jmedchem.0c01974
https://doi.org/10.1021/acs.jmedchem.0c01974
Publikováno v:
Slas Discovery
Iterative screening is a process in which screening is done in batches, with each batch filled by using machine learning to select the most promising compounds from the library based on the previous results. We believe iterative screening is poised t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72a46567ea7b830c56425924f8d9cce1
https://doi.org/10.1177/2472555220949495
https://doi.org/10.1177/2472555220949495
Autor:
Amy Monaghan, Paul Whiting, James Hillier, Svend Kjaer, Reinis R. Ruza, Jean-Paul Vincent, S. Frew, Paul V. Fish, L. Vecchia, William Mahy, James Sipthorp, Fredrik Svensson, Nicky J. Willis, Magda Bictash, Hannah Woodward, Patricia C. Salinas, Yuguang Zhao, E. Yvonne Jones
Publikováno v:
Journal of Medicinal Chemistry. 63:12942-12956
Carboxylesterase Notum is a negative regulator of the Wnt signaling pathway. There is an emerging understanding of the role Notum plays in disease, supporting the need to discover new small-molecule inhibitors. A crystallographic X-ray fragment scree
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deae46cf90f6f7beda225afadafa1e17
https://doi.org/10.1021/acs.jmedchem.0c01391
https://doi.org/10.1021/acs.jmedchem.0c01391
Autor:
Yuguang Zhao, William Mahy, Nicky J. Willis, Hannah L. Woodward, David Steadman, Elliott D. Bayle, Benjamin N. Atkinson, James Sipthorp, Luca Vecchia, Reinis R. Ruza, Karl Harlos, Fiona Jeganathan, Stefan Constantinou, Artur Costa, Svend Kjær, Magda Bictash, Patricia C. Salinas, Paul Whiting, Jean-Paul Vincent, Paul V. Fish, E. Yvonne Jones
The Wnt signaling suppressor Notum is a promising target for osteoporosis, Alzheimer's disease, and colorectal cancers. To develop novel Notum inhibitors, we used an X-ray crystallographic fragment screen with the Diamond-SGC Poised Library (DSPL) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f547dc38fab64d9f08bf48b45b75fa9e