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Akademický článek

Docosahexaenoic Acid and Eicosapentaenoic Acid Intakes Modulate the Association of FADS2 Gene Polymorphism rs526126 with Plasma Free Docosahexaenoic Acid Levels in Overweight Children

Autor: Alexandra Mihailescu, Vlad Serafim, Corina Paul, Nicoleta Andreescu, Diana-Andreea Tiugan, Paul Tutac, Iulian Velea, Cristian G. Zimbru, Costela Lacrimioara Serban, Adina Iuliana Ion, Vlad Laurentiu David, Alin Ionescu, Maria Puiu, Mihai Dinu Niculescu

Publikováno v: Applied Sciences, Vol 11, Iss 21, p 9845 (2021)

Polyunsaturated fatty acids are involved in a wide variety of biological functions. Linoleic acid and alpha-linolenic acid are two essential fatty acids that the body cannot synthesize. The conversion rates in the body depend on FADS2 genetic variant

Externí odkaz: https://doaj.org/article/e5418b276a28412aac556d54b9dc28c9

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Akademický článek

Single Nucleotide Polymorphisms in PEMT and MTHFR Genes are Associated with Omega 3 and 6 Fatty Acid Levels in the Red Blood Cells of Children with Obesity

Autor: Vlad Serafim, Adela Chirita-Emandi, Nicoleta Andreescu, Diana-Andreea Tiugan, Paul Tutac, Corina Paul, Iulian Velea, Alexandra Mihailescu, Costela Lăcrimioara Șerban, Cristian G. Zimbru, Maria Puiu, Mihai Dinu Niculescu

Publikováno v: Nutrients, Vol 11, Iss 11, p 2600 (2019)

Polyunsaturated fatty acids (PUFAs) play important roles in health and disease. PUFA levels are influenced by nutrition and genetic factors. The relationship between PUFA composition in red blood cells (RBCs) and genetic variations involved in PUFA m

Externí odkaz: https://doaj.org/article/95a28166f2c44b508359880f8a90347f

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Akademický článek

Exploring miRNA Biomarkers in Major Depressive Disorder: A Molecular Medicine Perspective

Autor: Cătălin Prodan-Bărbulescu, Laura Andreea Ghenciu, Edward Şeclăman, Georgeta Cristiana Bujor, Virgil Enătescu, Alexandra-Ioana Danila, Ecaterina Dăescu, Luminioara Maria Rosu, Ionuţ Flaviu Faur, Paul Tuţac, Norberth-Istvan Varga, Tanasescu Sonia, Ciprian Duță

Publikováno v: Current Issues in Molecular Biology, Vol 46, Iss 10, Pp 10846-10853 (2024)

Major depressive disorder (MDD) is a complex mental health condition with a multifaceted and incompletely elucidated pathophysiology. MicroRNAs (miRNAs) have emerged as potential biomarkers due to their role in gene regulation and the observed dysreg

Externí odkaz: https://doaj.org/article/c80baca626f049e38a249094d3a2dac5

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CHDH-PNPLA3 Gene–Gene Interactions Predict Insulin Resistance in Children with Obesity

Autor: Corina Paul, Nicoleta Andreescu, Costela Lacrimioara Serban, Iulian Velea, Paul Tutac, Alexandra Mihailescu, Diana-Andreea Tiugan, Adela Chirita-Emandi, Cristian G. Zimbru, Maria Puiu, Mihai D. Niculescu, Vlad Serafim

Publikováno v: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13:4483-4494

Introduction Insulin resistance plays a major role in metabolic syndrome and is recognized as the most common risk factor for non-alcoholic fatty liver disease (NAFLD). Identifying predictors for insulin resistance could optimize screening and preven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::735b084210ca627ac2284eeda3328fb8
https://doi.org/10.2147/dmso.s277268

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Docosahexaenoic Acid and Eicosapentaenoic Acid Intakes Modulate the Association of FADS2 Gene Polymorphism rs526126 with Plasma Free Docosahexaenoic Acid Levels in Overweight Children

Autor: Paul Tutac, Nicoleta Andreescu, Vlad Laurentiu David, Corina Paul, Alin Ionescu, Vlad Serafim, Maria Puiu, Costela Lacrimioara Serban, Alexandra Mihailescu, Mihai D. Niculescu, Cristian G. Zimbru, Diana-Andreea Tiugan, Iulian Velea, Adina Iuliana Ion

Publikováno v: Applied Sciences
Volume 11
Issue 21
Applied Sciences, Vol 11, Iss 9845, p 9845 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b300d206495d690e03724f8e154b35

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No clinical utility of common polymorphisms in IGF1, IRS1, GCKR, PPARG, GCK1 and KCTD1 genes previously associated with insulin resistance in overweight children from Romania and Moldova

Autor: Chiril Boiciuc, Paul Tutac, Maria Puiu, Adela Chirita-Emandi, Nicoleta Andreescu, Victoria Sacara, Corina Paul, Iulian Velea, Natalia Usurelu, Agneta Maria Pusztai, Lorina Vudu, Diana Munteanu, Victoria Hlistun

Publikováno v: Journal of Pediatric Endocrinology and Metabolism. 32:33-39

Background Previous genome-wide association studies (GWAS) identified IGF1, IRS1, GCKR, PPARG, GCK1 and KCTD1 as candidate genes for insulin resistance and type 2 diabetes (T2D). We investigated the associations of these previously reported common va

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ca2b58e8019272dbd34449baa1da56
https://doi.org/10.1515/jpem-2018-0288

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Association Between Thrombophilia Gene Polymorphisms and Recurrent Pregnancy Loss

Autor: Lavinia Maria Hogea, Dragos Erdelean, Paul Tutac, Andreea Iulia Dobrescu, Simona Farcas, Maria Puiu, Nicoleta Andreescu, Dan Navolan, Vladimir Poroch, Izabella Erdelean, Laura Alexandra Nussbaum

Publikováno v: Revista de Chimie. 69:3122-3125

Spontaneous miscarriage is reported in approximately 15% of the clinically recognized pregnancies. Several reports have showed an increased risk of miscarriage in patients with thrombophilia, but due to the heterogeneity of study design the role thro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d8c52b73c4405119e9beb83e2da5bc28
https://doi.org/10.37358/rc.18.11.6696

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Akademický článek

Identification of Specific Plasma miRNAs as Potential Biomarkers for Major Depressive Disorder

Autor: Cătălin Prodan-Bărbulescu, Cristian Daniel Alin, Ionuţ Flaviu Faur, Georgeta Cristiana Bujor, Edward Paul Şeclăman, Virgil Enătescu, Alexandra-Ioana Dănilă, Ecaterina Dăescu, Rami Hajjar, Laura Andreea Ghenciu, Paul Tuţac, Paul Paşca, Anca Maria Cimpean, Ciprian Duta

Publikováno v: Biomedicines, Vol 12, Iss 10, p 2165 (2024)

Backround: Depression is a significant concern in clinical and preclinical psychoneurobiological sciences due to its high prevalence and its individual and collective consequences. Identifying efficient biomarkers for accurate diagnosis is crucial, w

Externí odkaz: https://doaj.org/article/70a126896db0495cbcc92b89e9d774a1

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Challenges in reporting pathogenic/potentially pathogenic variants in 94 cancer predisposing genes - in pediatric patients screened with NGS panels

Autor: Adela Chirita-Emandi, Smaranda Arghirescu, Margit Serban, Nicoleta Andreescu, Paul Tutac, Maria Puiu, Cristian G. Zimbru

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)

The benefit of reporting unsolicited findings in Next Generation Sequencing (NGS) related to cancer genes in children may have implications for family members, nevertheless, could also cause distress. We aimed to retrospectively investigate germline

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02412038ae42b366de968a4336b277ee
https://doi.org/10.1038/s41598-019-57080-9

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Single Nucleotide Polymorphisms in PEMT and MTHFR Genes are Associated with Omega 3 and 6 Fatty Acid Levels in the Red Blood Cells of Children with Obesity

Autor: Maria Puiu, Costela Lăcrimioara Șerban, Corina Paul, Mihai D. Niculescu, Adela Chirita-Emandi, Alexandra Mihailescu, Diana-Andreea Tiugan, Paul Tutac, Iulian Velea, Vlad Serafim, Nicoleta Andreescu, Cristian G. Zimbru

Publikováno v: Nutrients, Vol 11, Iss 11, p 2600 (2019)
Nutrients
Volume 11
Issue 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29be9a6722f345ddda32aea5cb55ac26
https://www.mdpi.com/2072-6643/11/11/2600

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