Zobrazeno 1 - 10
of 321
pro vyhledávání: '"Paul Tempst"'
Autor:
Barbara Oldrini, Wan-Ying Hsieh, Hediye Erdjument-Bromage, Paolo Codega, Maria Stella Carro, Alvaro Curiel-García, Carl Campos, Maryam Pourmaleki, Christian Grommes, Igor Vivanco, Daniel Rohle, Craig M. Bielski, Barry S. Taylor, Travis J. Hollmann, Marc Rosenblum, Paul Tempst, John Blenis, Massimo Squatrito, Ingo K. Mellinghoff
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
The epidermal growth factor receptor (EGFR) signalling is regulated at multiple levels. Here the authors show that the importin RanBP6 acts as a tumor suppressor in Glioblastoma and regulates EGFR signalling through promoting translocation of STAT3 t
Externí odkaz:
https://doaj.org/article/015fa09cb6784ac18a7db7bbdca85e1c
Autor:
Ly P. Vu, Fabiana Perna, Lan Wang, Francesca Voza, Maria E. Figueroa, Paul Tempst, Hediye Erdjument-Bromage, Rui Gao, Sisi Chen, Elisabeth Paietta, Tony Deblasio, Ari Melnick, Yan Liu, Xinyang Zhao, Stephen D. Nimer
Publikováno v:
Cell Reports, Vol 5, Iss 6, Pp 1625-1638 (2013)
Defining the role of epigenetic regulators in hematopoiesis has become critically important, because recurrent mutations or aberrant expression of these genes has been identified in both myeloid and lymphoid hematological malignancies. We found that
Externí odkaz:
https://doaj.org/article/23494b692f7d460ba04c664afe18b963
Autor:
Dawei Gou, Monica Rubalcava, Silvia Sauer, Felipe Mora-Bermúdez, Hediye Erdjument-Bromage, Paul Tempst, Elisabeth Kremmer, Frank Sauer
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10581 (2010)
DNA methylation is fundamental for the stability and activity of genomes. Drosophila melanogaster and vertebrates establish a global DNA methylation pattern of their genome during early embryogenesis. Large-scale analyses of DNA methylation patterns
Externí odkaz:
https://doaj.org/article/2452cc1d8bf644ee833dcc7473a509d2
Autor:
Vlad C Seitan, Peter Banks, Steve Laval, Nazia A Majid, Dale Dorsett, Amer Rana, Jim Smith, Alex Bateman, Sanja Krpic, Arnd Hostert, Robert A Rollins, Hediye Erdjument-Bromage, Paul Tempst, Claire Y Benard, Siegfried Hekimi, Sarah F Newbury, Tom Strachan
Publikováno v:
PLoS Biology, Vol 4, Iss 8, p e242 (2006)
Saccharomyces cerevisiae Scc2 binds Scc4 to form an essential complex that loads cohesin onto chromosomes. The prevalence of Scc2 orthologs in eukaryotes emphasizes a conserved role in regulating sister chromatid cohesion, but homologs of Scc4 have n
Externí odkaz:
https://doaj.org/article/905526567a814e9d811096e004551e1c
Autor:
Kevin Lawlor, Paul Tempst, Guoan Zhang, Thomas A. Neubert, Fang-Ke Huang, John Philip, Noah Dephoure, Arpi Nazarian
Publikováno v:
Journal of Proteome Research. 16:1121-1132
Labeling peptides with isobaric tags is a popular strategy in quantitative bottom-up proteomics. In this study, we labeled six breast tumor cell lysates (1.34 mg proteins per channel) using 10-plex tandem mass tag reagents and analyzed the samples on
Autor:
Christian Hinze, Kai M. Schmidt-Ott, Efrat Bruck, Madison Jones, Paul E. Rosenstiel, Jonathan Barasch, Subodh J. Saggi, Juan A. Oliver, Justin Konig, Rong Deng, Tian Huai Shen, Tejashree S. Gopal, Max Werth, Hediye Erdjument-Bromage, Catherine S. Forster, Paolo Guarnieri, Nicholas P. Tatonetti, Roger W. Boles, Neal Paragas, Alexandra Tornato, Paul Tempst, Vivette D. D'Agati, Jacob Stauber, Xiaobo Gao, Katherine Xu, Gebhard Wagener
Publikováno v:
Journal of the American Society of Nephrology. 28:1729-1740
Two metrics, a rise in serum creatinine concentration and a decrease in urine output, are considered tantamount to the injury of the kidney tubule and the epithelial cells thereof (AKI). Yet neither criterion emphasizes the etiology or the pathogenet
Autor:
Ingo K. Mellinghoff, Craig M. Bielski, Maryam Pourmaleki, Paolo Codega, Maria Stella Carro, Massimo Squatrito, Barry S. Taylor, Álvaro Curiel-García, Paul Tempst, Daniel Rohle, John Blenis, Travis J. Hollmann, Barbara Oldrini, Igor Vivanco, Carl Campos, Hediye Erdjument-Bromage, Wan-Ying Hsieh, Marc K. Rosenblum, Christian Grommes
Publikováno v:
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Instituto de Salud Carlos III (ISCIII)
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Nature Communications
Transport of macromolecules through the nuclear pore by importins and exportins plays a critical role in the spatial regulation of protein activity. How cancer cells co-opt this process to promote tumorigenesis remains unclear. The epidermal growth f
Autor:
Mariana Yaneva, Brett S. Carver, Alan Saghatelian, James A. Eastham, San San Yi, Josep Villanueva, Andrew J. Vickers, Kevin Lawlor, Hans Lilja, Paul Tempst, John Philip, Mousumi Ghosh, Howard I. Scher, Arpi Nazarian, Melissa Assel
Publikováno v:
Molecular & Cellular Proteomics. 13:3082-3096
Cancer is responsible for many deaths and is a major source of healthcare expenditures. The identification of new, non-invasive biomarkers might allow improvement of the direct diagnostic or prognostic ability of already available tools. Here, we too
Autor:
Matthew J. Gamble, Christine Yang, W. Lee Kraus, Hediye Erdjument-Bromage, Nasun Hah, Eugene Park, Hongshan Chen, Kristine M. Hussey, Paul Tempst
Publikováno v:
Molecular and Cellular Biology. 34:2437-2449
MacroH2A1 is a histone variant harboring an ∼25-kDa carboxyl-terminal macrodomain. Due to its enrichment on the inactive X chromosome, macroH2A1 was thought to play a role in transcriptional repression. However, recent studies have shown that macro
Autor:
Hediye Erdjument-Bromage, Bernard H. Bochner, Mariana Yaneva, Irina Ostrovnaya, Paul Tempst, Hans Lilja, Jennifer M. Taylor, John Philip, Kevin Velasco
Publikováno v:
PROTEOMICS - Clinical Applications. 8:317-326
Purpose Proteases have been implicated in cancer progression and invasiveness. We have investigated the activities, as opposed to simple protein levels, of selected aminopeptidases in urine specimens to serve as potential novel biomarkers for urothel