Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Paul T. Wilder"'
Autor:
Erick O. Hernández‐Ochoa, Zephan Melville, Camilo Vanegas, Kristen M. Varney, Paul T. Wilder, Werner Melzer, David J. Weber, Martin F. Schneider
Publikováno v:
Physiological Reports, Vol 6, Iss 15, Pp n/a-n/a (2018)
Abstract Calmodulin (CaM) and S100A1 fine‐tune skeletal muscle Ca2+ release via opposite modulation of the ryanodine receptor type 1 (RyR1). Binding to and modulation of RyR1 by CaM and S100A1 occurs predominantly at the region ranging from amino a
Externí odkaz:
https://doaj.org/article/8231af2f14e64b69a8b603a1214e2fbd
Autor:
Lijia Chen, Jay Chauhan, Jeremy L. Yap, Christopher C. Goodis, Paul T. Wilder, Steven Fletcher
Publikováno v:
RSC Medicinal Chemistry. 14:103-112
Deconstruction of a bicyclic tetrahydroquinoline-6-carboxylic acid scaffold into aminosalicylic acids yielded dual MCL-1/BCL-xL inhibitors from an MCL-1 selective lead.
Autor:
Milad J Alasady, Alexander R Terry, Adam D Pierce, Michael C Cavalier, Catherine S Blaha, Kaylin A Adipietro, Paul T Wilder, David J Weber, Nissim Hay
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0256238 (2021)
S100B is frequently elevated in malignant melanoma. A regulatory mechanism was uncovered here in which elevated S100B lowers mRNA and secreted protein levels of interleukin-6 (IL6) and inhibits an autocrine loop whereby IL6 activates STAT3 signaling.
Externí odkaz:
https://doaj.org/article/9e8cdda96b274951af8b33b4ddfe5607
Publikováno v:
Drug development researchREFERENCES. 83(8)
MCL-1 is a member of the BCL-2 family of proteins that regulates the mitochondrial pathway of apoptosis. Overexpression of MCL-1 is associated with the development and progression of a range of human cancers, and is also responsible for the onset of
Autor:
Brandon Drennen, Christopher C. Goodis, Nathan Bowen, Wenbo Yu, Gregory Vickers, Paul T. Wilder, Alexander D. MacKerell, Steven Fletcher
Publikováno v:
RSC Med Chem
Overexpression of the anti-apoptotic BCL-2 proteins is associated with the development and progression of a range of cancers. Venetoclax, an FDA-approved BCL-2 inhibitor, is fast becoming the standard-of-care for acute myeloid leukemia and chronic ly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cba2c05c87cb2cc513fd1a3a6958569
https://europepmc.org/articles/PMC9384788/
https://europepmc.org/articles/PMC9384788/
Autor:
Paul T. Wilder, Steven Fletcher, Brandon Drennen, Ivie L. Conlon, Rebecca Rothhaas, Samuel J. Hughes, Alexander D. MacKerell, Maryanna E. Lanning
Publikováno v:
ChemMedChem
Protein-protein interactions (PPIs), many of which are dominated by α-helical recognition domains, play key roles in many essential cellular processes, and the dysregulation of these interactions can cause detrimental effects. For instance, aberrant
Autor:
Braden M. Roth, Paul T. Wilder, Christopher Peralta, Richard R. Rustandi, Jessica W. Olson, Xingjian Xu, Sarah L. J. Michel, Wenbo Yu, Mary E. Cook, Alexander D. MacKerell, Heather M. Neu, Kristen M. Varney, Thomas E. Cleveland, Alexander Grishaev, John W. Loughney, Catherine Lancaster, Danya Ben-Hail, E. Pozharski, Adam Kristopeit, Sianny Christanti, Amedee des Georges, Kaylin A. Adipietro, Dorothy Beckett, Raquel Godoy-Ruiz, David J. Weber
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proc Natl Acad Sci U S A
Proc Natl Acad Sci U S A
Significance There is a burden from Clostridium difficile infection throughout the world, and the Centers for Disease Control reports more than 500,000 cases annually in the United States, resulting in an estimated 15,000 deaths. In addition to the l
Publikováno v:
Biomolecular Nmr Assignments
Vitamin A is a necessary nutrient for all mammals, and it is required for the transcription of many genes and vital for vision. While fasting, the vitamin A alcohol form (Retinol) from storage in the liver is mobilized and transported through the blo
Autor:
Christopher Krauss, David J. Weber, Birsen Y. Varisli, Pumtiwitt C. McCarthy, Fazlul H. Sarkar, Angela Winstead, Douglas M. Ho, Kayla Johnston, Saroj K. Pramanik, Yongchao Zhang, Paul T. Wilder, Hirendra N. Banerjee, Santosh K. Mandal, Sujan Ghimire, Fasil A. Abebe
DNA-binding studies of a variety of rhenium(I) tricarbonyl complexes are known. Primarily the rhenium complexes bind to DNA through intercalation or minor groove or both. We synthesized a novel organometallic salt of the type, [Re(µ-H)Re]+[Re(µ-OR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8333d2031de89a009ad5399426d95ee
https://doi.org/10.21203/rs.3.rs-165666/v1
https://doi.org/10.21203/rs.3.rs-165666/v1
Autor:
Heather M. Neu, Christopher Peralta, Paul T. Wilder, Braden M. Roth, Sianny Christanti, Danya Ben-Hail, Amedee des Georges, Mary E. Cook, Sarah L. J. Michel, Richard R. Rustandi, Xingjian Xu, Edwin Pozharski, Catherine Lancaster, Thomas E. Cleveland, John W. Loughney, Jessica W. Olson, Alexander Grishaev, David J. Weber, Raquel Godoy-Ruiz, Dorothy Beckett, Alex D. MacKerell, Kaylin A. Adipietro, Wenbo Yu, Kristen M. Varney, Adam Kristopeit
TargetingClostridium difficileinfection (CDI) is challenging because treatment options are limited, and high recurrence rates are common. One reason for this is that hypervirulent CDI often has a binary toxin termed theC. difficiletoxin (CDT), in add
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca4dbdd79ce3486ec0bdcce30e623d8