Pristanic acid and phytanic acid: naturally occurring ligands for the nuclear receptor peroxisome proliferator-activated receptor α

Autor: Anna W.M. Zomer, Bart van der Burg, Gerbert A. Jansen, Ronald J.A. Wanders, Bwee Tien Poll-The, Paul T. van der Saag

Publikováno v: Journal of Lipid Research, Vol 41, Iss 11, Pp 1801-1807 (2000)

Phytanic acid and pristanic acid are branched-chain fatty acids, present at micromolar concentrations in the plasma of healthy individuals. Here we show that both phytanic acid and pristanic acid activate the peroxisome proliferator-activated recepto

Externí odkaz: https://doaj.org/article/43d5c092d7394de4b9d9030cd5ed9c7c

Food-associated estrogenic compounds induce estrogen receptor-mediated luciferase gene expression in transgenic male mice

Autor: Marcel G.R. ter Veld, J.H.J. van den Berg, Paul T. van der Saag, Albertinka J. Murk, Ivonne M.C.M. Rietjens, E. Zawadzka

Publikováno v: Chemico-Biological Interactions, 174(2), 126-133. Elsevier Ireland Ltd
Chemico-Biological Interactions, 174(2), 126-133
Chemico-Biological Interactions 174 (2008) 2

The present paper aims at clarifying to what extent seven food-associated compounds, shown before to be estrogenic in vitro, can induce estrogenic effects in male mice with an estrogen receptor (ER)-mediated luciferase (luc) reporter gene system. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473d779fc9495504f28903a0d79ad231
https://doi.org/10.1016/j.cbi.2008.03.019

The stimulation of cell proliferation by quercetin is mediated by the estrogen receptor

Autor: Natasja Jacobs, Albertinka J. Murk, Hester van der Woude, Paul T. van der Saag, Ivonne M.C.M. Rietjens, Marcel G.R. ter Veld

Publikováno v: Molecular Nutrition & Food Research 49 (2005) 8
Molecular Nutrition & Food Research, 49(8), 763-771

Quercetin causes biphasic modulation of the proliferation of specific colon and mammary cancer cells. In this study, the possible involvement of the estrogen receptor (ER) in the stimulation of cell proliferation by quercetin was investigated. For th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c12f152d1b041f5b197ab9a41c8331
https://doi.org/10.1002/mnfr.200500036

Toward More Useful In Vitro Toxicity Data with Measured Free Concentrations

Autor: Richard H. M. M. Schreurs, Bart van der Burg, Frans J. M. Busser, Joop L. M. Hermens, Paul T. Van Der Saag, Minne B. Heringa

Publikováno v: Environmental Science & Technology. 38:6263-6270

In vitro assays and computer models are promising alternatives for in vivo animal testing, but the power of these alternative methods to predict in vivo risk is still very limited. One step forward is to make the outcome of in vitro assays (such as m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a32f416ab89bb876608ce54e77d91cb
https://doi.org/10.1021/es049285w

Expression profiles and functional implications of p53-like transcription factors in thymic epithelial cell subtypes

Autor: Shigeaki Yokoyama, Tomoki Kikuchi, Noriyuki Sato, Shingo Ichimiya, Laura Crisa, Nobuhiko Kondo, Shigeru Koshiba, Paul T. van der Saag, Akiko Tonooka, Takashi Kojima

Publikováno v: International Immunology. 16:831-841

In this study, we investigated the localization and functional significance of p53 tumor suppressor-like molecules, p63 and p73, in human thymic epithelial cells (TECs). Immunohistochemical studies showed particular distribution profiles of p63 and p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::607ad698c56323b5bf592a2f2fb1785f
https://doi.org/10.1093/intimm/dxh087