Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Paul T. Schuber"'
Autor:
William G. Bornmann, Basvoju A. Bhanu Prasad, Paul T. Schuber, Ashutosh Pal, Bharat B. Aggarwal, Sahdeo Prasad, Bokyung Sung
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:435-439
A gram scale synthesis of the glucuronide metabolites of curcumin were completed in four steps. The newly synthesized curcumin glucuronide compounds 2 and 3 along with curcumin 1 were tested and their anti-proliferative effects against KBM-5, Jurkat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b63dc4a6e9181804017288a752740d
https://doi.org/10.1016/j.bmc.2013.11.006
https://doi.org/10.1016/j.bmc.2013.11.006
Publikováno v:
Tetrahedron Letters. 54:5555-5557
The C1–C6 region of the potent cytotoxic agent psymberin has been synthesized. The key transformations of the synthesis are an auxiliary-controlled addition of a Sn(II)-glycolate enolate to an aldehyde to yield the anti -aldol product and transform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92dea9d60abf110ed48dd2d22ef66826
https://doi.org/10.1016/j.tetlet.2013.05.153
https://doi.org/10.1016/j.tetlet.2013.05.153
Autor:
Paul T. Schuber, Robert M. Williams
Publikováno v:
Tetrahedron Letters. 53:380-382
A procedure for the asymmetric synthesis of a novel β-hydroxy-α-amino acid deriverative to be used in the preparation of the natural product MPC1001 and analogs has been developed. The amino acid was efficiently prepared in six steps via a Mukaiyam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7019a8d800dfa04355236d47b3fa88a
https://doi.org/10.1016/j.tetlet.2011.11.069
https://doi.org/10.1016/j.tetlet.2011.11.069
Autor:
Basvoju A. Bhanu Prasad, Juri G. Gelovani, Duoli Sun, Zhenghong Peng, William G. Bornmann, Paul T. Schuber, Wai Kwan Alfred Yung, Yunming Ying, David Maxwell
Publikováno v:
Tetrahedron. 70(4)
A virtual library of 54 inositol analog mimics of In(1,4,5)P3 has been docked, scored, and ranked within the binding site of human inositol 1,4,5-trisphosphate 3-kinase A (IP3-3KA). Chemical synthesis of the best scoring structure that also met dista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a856450f659a9d060150f8365cd0010
https://pubmed.ncbi.nlm.nih.gov/25110363
https://pubmed.ncbi.nlm.nih.gov/25110363
Autor:
David Maxwell, Duoli Sun, Alexander Levitzki, Nicholas J. Donato, Dongmei Han, William G. Bornmann, Basvoju A. Bhanu Prasad, Yunming Ying, Paul T. Schuber, Zhenghong Peng, Matthew A. Young, Shimei Wang, H. D. Hollis Showalter, Ashutosh Pal, Vaibhav Kapuria, Liwei Gao, Moshe Talpaz
Publikováno v:
Bioorganicmedicinal chemistry. 22(4)
A series of degrasyn-like symmetrical compounds have been designed, synthesized, and screened against B cell malignancy (multiple myeloma, mantle cell lymphoma) cell lines. The lead compounds T5165804 and CP2005 showed higher nanomolar potency agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2aa35805cbbd5ebf2c7cefcd91b459
https://pubmed.ncbi.nlm.nih.gov/24457091
https://pubmed.ncbi.nlm.nih.gov/24457091
Autor:
David Maxwell, Garth Powis, Diana V. Martin, William G. Bornmann, Basvoju A. Bhanu Prasad, Paul T. Schuber, David J. Yang, Liwei Guo, Hiroaki Kurihara, Dongmei Han, Zhenghong Peng, Duoli Sun, Juri G. Gelovani
An improved method for the synthesis of 17β-hydroxy-16α-iodo-wortmannin along with the first synthesis of 17β-hydroxy-16α-iodoPX866 and [(131)I] radiolabeled 17β-hydroxy-16α-[(131)I]iodo-wortmannin, as potential PET tracers for PI3K was also de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bebd8bfcb009d2a531a00faf1b0cb446
https://europepmc.org/articles/PMC3960976/
https://europepmc.org/articles/PMC3960976/
Autor:
Robert M. Williams, Paul T. Schuber
Publikováno v:
ChemInform. 43
The approach towards the total synthesis of MPC1001 is based on disconnections across the dioxopiperazine and the diaryl ether subunit of MPC1001 utilizing a late-stage construction of the oxepin ring via the highly substituted pyrrolidine (IV), whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89592dae230884010723155f228ed6b9
https://doi.org/10.1002/chin.201222185
https://doi.org/10.1002/chin.201222185
Autor:
Paul T. Schuber, Zhuonan Zhuang, William G. Bornmann, Duoli Sun, David Maxwell, Qianghua Xia, Zhenghong Peng, Paul J. Chiao
Publikováno v:
Cancer Research. 74:1727-1727
Transforming growth factor- (TGF-) activation kinase (TAK1, MAP3K7) is a member of MAPKKK family [1]. It was well established that TAK1 plays a key role in both TNFα and IL-1 pathway. Knock down of TAK1 impaired the activation of IKK and JNK by TNF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf9be4ddeb3483076116e3459ee09da8
https://doi.org/10.1158/1538-7445.am2014-1727
https://doi.org/10.1158/1538-7445.am2014-1727