Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Paul T. Massa"'
Autor:
Erin S. Reynolds, Charles E. Hart, Jacob T. Nelson, Brandon J. Marzullo, Allen T. Esterly, Dakota N. Paine, Jessica Crooker, Paul T. Massa, Saravanan Thangamani
Publikováno v:
Viruses, Vol 16, Iss 6, p 820 (2024)
Tick-borne flaviviruses (TBFV) can cause severe neuroinvasive disease which may result in death or long-term neurological deficit in over 50% of survivors. Multiple mechanisms for invasion of the central nervous system (CNS) by flaviviruses have been
Externí odkaz:
https://doaj.org/article/f5073f2bd0724a41bce39f5cdf2d1ee9
Autor:
Yunting Zhu, Maree J. Webster, Caitlin E. Murphy, Frank A. Middleton, Paul T. Massa, Chunyu Liu, Rujia Dai, Cyndi Shannon Weickert
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Approximately 40% of people with schizophrenia are classified as having “high inflammation.” This subgroup has worse neuropathology than patients with “low inflammation.” Thus, one would expect the resident microglia and possibly monocyte-der
Externí odkaz:
https://doaj.org/article/73e83ffade6b4cb7bee7ea95c2f2594a
Autor:
Liam P Coyne, Xiaowen Wang, Jiyao Song, Ebbing de Jong, Karin Schneider, Paul T Massa, Frank A Middleton, Thomas Becker, Xin Jie Chen
Mitochondrial biogenesis requires the import of >1,000 mitochondrial preproteins from the cytosol. Most studies on mitochondrial protein import are focused on the core import machinery. Whether and how the biophysical properties of substrate preprote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71df124ff3f6c338187d5a7999ae35f9
https://doi.org/10.1101/2022.09.20.508789
https://doi.org/10.1101/2022.09.20.508789
Publikováno v:
J Vis Exp
The histologic analysis of brain and spinal cord specimens isolated from mice is common practice for the assessment of pathology in this model system. To maintain the morphology of these delicate tissues, it is routine to administer a chemical fixati
Autor:
Paul T. Massa, Scott B. Minchenberg
Publikováno v:
J Neuroimmunol
Glycolysis and mitochondrial respiration are essential for oligodendrocyte metabolism in both the developing and adult CNS. Based on recent reports on the effects of the proinflammatory cytokine IFN-γ on metabolism and on oligodendrocytes, we addres
Autor:
Frank A. Middleton, Liam P. Coyne, Jiyao Song, Karin M. Schneider, Thomas Becker, Paul T. Massa, Xin Jie Chen, Ebbing P. De Jong, Xiaowen Wang
Publikováno v:
SSRN Electronic Journal.
Mitochondrial protein import is essential for mitochondrial function, yet the breadth of physiologically-relevant import stressors is underexplored. Here, we show that mutant mitochondrial preproteins can disrupt global protein import to cause diseas
Autor:
Chad A. Hudson, Bridget Shafit-Zagardo, George P. Christophi, Alex K. Ray, Paul T. Massa, Daria LaRocca, Scott B. Minchenberg, Ross C. Gruber
Publikováno v:
Glia. 63:1753-1771
We have previously described reduced myelination and corresponding myelin basic protein (MBP) expression in the central nervous system of Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP-1) deficient motheaten (me/me) mice compare
Publikováno v:
The Journal of Immunology. 194:2796-2809
Virus-induced myositis is an emerging global affliction that remains poorly characterized with few treatment options. Moreover, muscle-tropic viruses often spread to the CNS, causing dramatically increased morbidity. Therefore, there is an urgent nee
Macrophages are common targets for infection and innate immune activation by many pathogenic viruses including the neurotropic Theiler’s Murine Encephalomyelitis Virus (TMEV). As both infection and innate activation of macrophages are key determina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4903d8e1ebe44fa49c3d97203a78956
https://europepmc.org/articles/PMC5803477/
https://europepmc.org/articles/PMC5803477/