Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Paul T. Kirschmeier"'
Autor:
Matthew V. Lorenzi, Raluca I. Verona, Kwok-Kin Wong, Christopher Moy, Pasi A. Janne, Kathryn Packman, Paul T. Kirschmeier, Mark A. Bittinger, Sylvie Laquerre, Catherine Sanders, Julie A. Rytlewski, Andrew H. Beck, Aditya Khosla, Jessie M. English, Catherine Ferrante, Elena Ivanova, Samuel N. Regan, Dyane Bailey, Martha R. Gowaski, Kristin DePeaux, Abha Dhaneshwar, Jeffrey Liu, Dennis M. Bonal, Wei Huang, Enrique Zudaire, Sima J. Zacharek, Mari Kuraguchi, Sangeetha Palakurthi
Supplemental figure legends 1-8, Supplementary tables 1-5, and Supplementary methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::081db4e460edcdbbb5c8116b2f80a570
https://doi.org/10.1158/2326-6066.22543410
https://doi.org/10.1158/2326-6066.22543410
Autor:
Matthew V. Lorenzi, Raluca I. Verona, Kwok-Kin Wong, Christopher Moy, Pasi A. Janne, Kathryn Packman, Paul T. Kirschmeier, Mark A. Bittinger, Sylvie Laquerre, Catherine Sanders, Julie A. Rytlewski, Andrew H. Beck, Aditya Khosla, Jessie M. English, Catherine Ferrante, Elena Ivanova, Samuel N. Regan, Dyane Bailey, Martha R. Gowaski, Kristin DePeaux, Abha Dhaneshwar, Jeffrey Liu, Dennis M. Bonal, Wei Huang, Enrique Zudaire, Sima J. Zacharek, Mari Kuraguchi, Sangeetha Palakurthi
The success of targeted or immune therapies is often hampered by the emergence of resistance and/or clinical benefit in only a subset of patients. We hypothesized that combining targeted therapy with immune modulation would show enhanced antitumor re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39ef82160a04751b2f6d5b28b394c18e
https://doi.org/10.1158/2326-6066.c.6550248
https://doi.org/10.1158/2326-6066.c.6550248
Autor:
Matthew V. Lorenzi, Raluca I. Verona, Kwok-Kin Wong, Christopher Moy, Pasi A. Janne, Kathryn Packman, Paul T. Kirschmeier, Mark A. Bittinger, Sylvie Laquerre, Catherine Sanders, Julie A. Rytlewski, Andrew H. Beck, Aditya Khosla, Jessie M. English, Catherine Ferrante, Elena Ivanova, Samuel N. Regan, Dyane Bailey, Martha R. Gowaski, Kristin DePeaux, Abha Dhaneshwar, Jeffrey Liu, Dennis M. Bonal, Wei Huang, Enrique Zudaire, Sima J. Zacharek, Mari Kuraguchi, Sangeetha Palakurthi
Supplemental Figures 1-8
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3a9d829db39fa7ca6cf8c4ce7a4a356
https://doi.org/10.1158/2326-6066.22543413
https://doi.org/10.1158/2326-6066.22543413
Autor:
David A. Barbie, Cloud Peter Paweletz, David Dornan, Kwok-Kin Wong, Genevieve M. Boland, Roger D. Kamm, Keith T. Flaherty, F. Stephen Hodi, Patrick A. Ott, Jochen H. Lorch, Paul T. Kirschmeier, Gordon J. Freeman, Eliezer M. Van Allen, Levi A. Garraway, Meenhard Herlyn, Juan Miret, Charles H. Yoon, Raphael Bueno, William G. Richards, Joshua Wong, Vivek Sivathanu, Thanh U. Barbie, Benchun Miao, Rohit Thummalapalli, Shunsuke Kitajima, Brian C. Miller, James M. Cleary, Sareh Parangi, Viswanath Gunda, Guilherme Rabinowits, Nicole R. LeBoeuf, Manisha Thakuria, Benjamin Izar, Parin Shah, Mei-Ju Su, Lisa Cameron, Anat O. Stemmer-Rachamimov, Jean-Pierre Eliane, Adriano Piris, Mai P. Hoang, Wei Huang, Glenn J. Hanna, Shuai Li, Hua Zhang, Eric S. Wang, Raven Vlahos, Marc R. Hammond, Tran C. Thai, Israel Cañadas, Michal Barzily-Rokni, Zhiheng Jia, Lance Stapleton, Maria Anguiano, Lauren Keogh, Robert E. Jones, Asaf Rotem, Alicia Smart, Bart Phillips, Prafulla C. Gokhale, Andrew Portell, Joshua A. Kaplan, Chandrasekar Venkataramani, Max Quinn, Ashley Merlino, Jong Wook Kim, Hans Vitzthum, Mark Bittinger, Sangeetha Palakurthi, Zhi Wei, Chaoran Cheng, Tian Tian, Gao Zhang, William Walker, Meng Xiao He, Diana Miao, Hongye Liu, Jiehui Deng, Michaela Bowden, Chensheng W. Zhou, Susanna Stinson, Elena Ivanova, Patrick H. Lizotte, Amir R. Aref, Russell W. Jenkins
PDOTS Movie 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5816e3f89be3fcf42e03c4886a26bb
https://doi.org/10.1158/2159-8290.22531837.v1
https://doi.org/10.1158/2159-8290.22531837.v1
Autor:
Pasi A. Jänne, Stephen Wang, Sujuan Guo, Jiannan Guo, Paul T. Kirschmeier, Jens Köhler, Zihan Wei, Fangxin Hong, Pratik R. Chopade, Prafulla C. Gokhale, Christie J. Lau, Kshiti H. Dholakia, Nam Doo Kim, Taebo Sim, Luke J. Taus, Yanan Kuang, Cloud P. Paweletz, Magda Bahcall
Application of Bliss independence to test for synergy effect of TKI combination treatment in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4903139a78bc221e2202f3b12db12a51
https://doi.org/10.1158/1535-7163.22521927.v1
https://doi.org/10.1158/1535-7163.22521927.v1
Autor:
Yan Wang, Erick J. Morris, Richard E. Middleton, Paul T. Kirschmeier, Leigh Zawel, Cynthia Seidel-Dugan, Pasi A. Jánne, Kwok-Kin Wong, Kumiko Nagashima, Heather Hirsch, Steven Ripley, Chris Hulton, Weiqun Zhang, Rossana Chung, Stephen Wu, Peter Strack, Thi T. Nguyen, Brian Dolinski, Jongwon Lim, Rafael Fernandez, Haiyan Yan, Qi Pan, Asli Muvaffak
PDF file - 1334KB, S1. IC50 values of TBK1 inhibitors Compound number 5, Compound number 4 and Compound number 3 from the selected PDAC, colorectal cancer and NSCLC cancer cell lines using are shown. Table 1S. List of shRNAs Targeting TBK1 Table 2S.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98442b5d4353d94a24d08eb4fa097ec2
https://doi.org/10.1158/1541-7786.22511083
https://doi.org/10.1158/1541-7786.22511083
Autor:
David A. Barbie, Cloud Peter Paweletz, David Dornan, Kwok-Kin Wong, Genevieve M. Boland, Roger D. Kamm, Keith T. Flaherty, F. Stephen Hodi, Patrick A. Ott, Jochen H. Lorch, Paul T. Kirschmeier, Gordon J. Freeman, Eliezer M. Van Allen, Levi A. Garraway, Meenhard Herlyn, Juan Miret, Charles H. Yoon, Raphael Bueno, William G. Richards, Joshua Wong, Vivek Sivathanu, Thanh U. Barbie, Benchun Miao, Rohit Thummalapalli, Shunsuke Kitajima, Brian C. Miller, James M. Cleary, Sareh Parangi, Viswanath Gunda, Guilherme Rabinowits, Nicole R. LeBoeuf, Manisha Thakuria, Benjamin Izar, Parin Shah, Mei-Ju Su, Lisa Cameron, Anat O. Stemmer-Rachamimov, Jean-Pierre Eliane, Adriano Piris, Mai P. Hoang, Wei Huang, Glenn J. Hanna, Shuai Li, Hua Zhang, Eric S. Wang, Raven Vlahos, Marc R. Hammond, Tran C. Thai, Israel Cañadas, Michal Barzily-Rokni, Zhiheng Jia, Lance Stapleton, Maria Anguiano, Lauren Keogh, Robert E. Jones, Asaf Rotem, Alicia Smart, Bart Phillips, Prafulla C. Gokhale, Andrew Portell, Joshua A. Kaplan, Chandrasekar Venkataramani, Max Quinn, Ashley Merlino, Jong Wook Kim, Hans Vitzthum, Mark Bittinger, Sangeetha Palakurthi, Zhi Wei, Chaoran Cheng, Tian Tian, Gao Zhang, William Walker, Meng Xiao He, Diana Miao, Hongye Liu, Jiehui Deng, Michaela Bowden, Chensheng W. Zhou, Susanna Stinson, Elena Ivanova, Patrick H. Lizotte, Amir R. Aref, Russell W. Jenkins
In vitro kinase inhibitory activity of Compound 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee36e2ca091d61ba8d57a8c6457e16a
https://doi.org/10.1158/2159-8290.22531825
https://doi.org/10.1158/2159-8290.22531825
Autor:
Pasi A. Jänne, David A. Barbie, Nathanael S. Gray, Paul T. Kirschmeier, Mark Bittinger, Mari Kuraguchi, Hsiang-Fong Kao, Erica Fitzpatrick, Lauren Badalucco, Meghana Kulkarni, Aaron Yang, Naomi Mayman, Abha Dhaneshwar, Stephen Wang, Luke J. Taus, Megan E. Cavanaugh, Troy A. Luster, Ruey-Long Hong, Patrick H. Lizotte
Table 1 compound list
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae2ef21b2575a2f8eedd65cee7b044db
https://doi.org/10.1158/2326-6066.22539421.v1
https://doi.org/10.1158/2326-6066.22539421.v1
Autor:
Pasi A. Jänne, David A. Barbie, Nathanael S. Gray, Paul T. Kirschmeier, Mark Bittinger, Mari Kuraguchi, Hsiang-Fong Kao, Erica Fitzpatrick, Lauren Badalucco, Meghana Kulkarni, Aaron Yang, Naomi Mayman, Abha Dhaneshwar, Stephen Wang, Luke J. Taus, Megan E. Cavanaugh, Troy A. Luster, Ruey-Long Hong, Patrick H. Lizotte
We developed a screening assay in which luciferized ID8 expressing OVA was cocultured with transgenic CD8+ T cells specifically recognizing the model antigen in an H-2b–restricted manner. The assay was screened with a small-molecule library to iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2ad3797aa3be0a0555e8bfa1e8f6433
https://doi.org/10.1158/2326-6066.c.6549088.v1
https://doi.org/10.1158/2326-6066.c.6549088.v1
Autor:
Pasi A. Jänne, Stephen Wang, Sujuan Guo, Jiannan Guo, Paul T. Kirschmeier, Jens Köhler, Zihan Wei, Fangxin Hong, Pratik R. Chopade, Prafulla C. Gokhale, Christie J. Lau, Kshiti H. Dholakia, Nam Doo Kim, Taebo Sim, Luke J. Taus, Yanan Kuang, Cloud P. Paweletz, Magda Bahcall
MET-targeted therapies are clinically effective in MET-amplified and MET exon 14 deletion mutant (METex14) non–small cell lung cancers (NSCLCs), but their efficacy is limited by the development of drug resistance. Structurally distinct MET tyrosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cb636b4d303925dcf3349ce844b41a8
https://doi.org/10.1158/1535-7163.c.6543231.v1
https://doi.org/10.1158/1535-7163.c.6543231.v1