Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Paul T. Jantzen"'
Publikováno v:
Neuroscience. 144:950-960
Vaccination with Aβ1–42 and treatment with NCX-2216, a novel nitric oxide releasing flurbiprofen derivative, have each been shown separately to reduce amyloid deposition in transgenic mice and have been suggested as potential therapies for Alzheim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c5f7955424bbed38b1261d6d2bd3654
https://doi.org/10.1016/j.neuroscience.2006.10.020
https://doi.org/10.1016/j.neuroscience.2006.10.020
Publikováno v:
Microscopy Today. 13:8-17
Plants that are used for taxonomic research are generally preserved by drying them out while they are being pressed flat for easy storage. This pressed plant material, is placed in a herbarium, in phylogenetic order, based on the species, genus, fami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e16cd7edd6bb6588c0e36f807ce6b3cc
https://doi.org/10.1017/s1551929500051579
https://doi.org/10.1017/s1551929500051579
Autor:
Paul T. Jantzen, Donna M. Wilcock, Kenneth E. Ugen, Dave Morgan, Marcia N. Gordon, Giovanni DiCarlo
Publikováno v:
Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents. 3:27-32
One increasingly dominant hypothesis regarding the pathogenesis of Alzheimer dementia is the inflammationhypothesis. In brief, this hypothesis argues that at least some of the neurodegeneration found in this disease issecondary to excessive activatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::208a45a3fcbcfa5351f77e41cb10226b
https://doi.org/10.2174/1568013033358680
https://doi.org/10.2174/1568013033358680
Autor:
Charlotte O'Leary, Jennifer Jackson, Giovanni DiCarlo, Donna M. Wilcock, Kristal W. Boyett, Dave Morgan, Marcia N. Gordon, Paul T. Jantzen
Publikováno v:
Neurochemical Research. 28:83-93
Human C1q when injected directly into hippocampus and cortex of doubly transgenic APP+PS1 mice results in the increase of Congo red-positive fibrillar deposits. Although there was no significant change in overall area stained for Aβ total, qualitati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3966b9b93f588b0e8a9bcdf5204c32c
https://doi.org/10.1023/a:1021600212829
https://doi.org/10.1023/a:1021600212829
Autor:
John L. Wallace, Karen E. Connor, Giovanni DiCarlo, Dave Morgan, Marcia N. Gordon, Paul T. Jantzen, Amyn M. Rojiani, Domenico Coppola, Gary L. Wenk
Publikováno v:
The Journal of Neuroscience. 22:2246-2254
3-4-(2-Fluoro-α-methyl-[1,1′-biphenyl]-4-acetyloxy)-3-methoxyphenyl]-2-propenoic acid 4-nitrooxy butyl ester (NCX-2216), a nitric oxide (NO)-releasing derivative of the cyclooxygenase-1-preferring nonsteroidal anti-inflammatory drug (NSAID) flurbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eac115945632f119829c2e2993a8d1ee
https://doi.org/10.1523/jneurosci.22-06-02246.2002
https://doi.org/10.1523/jneurosci.22-06-02246.2002
Autor:
Chad A. Dickey, Kristal W. Boyett, Paul E. Gottschall, Donna M. Wilcock, David Morgan, Paul T. Jantzen, Giovanni DiCarlo, Karen E. Connor, John Hardy, Kenneth E. Ugen, Jason Melachrino, Marcia N. Gordon
Publikováno v:
DNA and Cell Biology. 20:731-736
There have been several reports on the use of beta-amyloid (Abeta ) vaccination in different mouse models of Alzheimer's disease (AD) and its effects on pathology and cognitive function. In this report, the histopathologic findings in the APP+PS1 dou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2af02af46378cc62a241d384010576f
https://doi.org/10.1089/10445490152717596
https://doi.org/10.1089/10445490152717596
Autor:
Jaime M. Hatcher, Marcia N. Gordon, David M. Diamond, Dave Morgan, Leigh Ann Austin, Donna M. Wilcock, Paul T. Jantzen, Giovanni DiCarlo, Gary W. Arendash
Publikováno v:
DNA and Cell Biology. 20:737-744
Long-term vaccinations with human beta-amyloid peptide 1-42 (Abeta1-42) have recently been shown to prevent or markedly reduce Abeta deposition in the PDAPP transgenic model of Alzheimer's disease (AD). Using a similar protocol to vaccinate 7.5-month
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d86fe193196fe1431c58fbe37d0de1
https://doi.org/10.1089/10445490152717604
https://doi.org/10.1089/10445490152717604
Autor:
W.Paul E Gottschall, Paul T. Jantzen, David M. Diamond, Giovanni DiCarlo, Jaime M. Hatcher, Kristal V Boyett, Marcia N. Gordon, Caroline Hope, David L. King, Dave Morgan, Gary W. Arendash
Publikováno v:
Neurobiology of Aging. 22:377-385
Doubly transgenic mAPP+mPS1 mice (15-16 months) had impaired cognitive function in a spatial learning and memory task that combined features of a water maze and a radial arm maze. Nontransgenic mice learned a new platform location each day during 4 c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8da3001c999848a517316a1ab23560
https://doi.org/10.1016/s0197-4580(00)00249-9
https://doi.org/10.1016/s0197-4580(00)00249-9
Autor:
Donna M. Wilcock, Dave Morgan, Paul T. Jantzen, David M. Diamond, John Hardy, Karen E. Connor, Kenneth E. Ugen, Karen Duff, Marcia N. Gordon, Paul E. Gottschall, Giovanni DiCarlo, Gary W. Arendash, Caroline Hope, Jaime M. Hatcher, Chad A. Dickey
Publikováno v:
Nature. 408:982-985
Vaccinations with amyloid-beta peptide (A beta) can dramatically reduce amyloid deposition in a transgenic mouse model of Alzheimer's disease. To determine if the vaccinations had deleterious or beneficial functional consequences, we tested eight mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccc57869ecf22e9c0b70a1c95ab97176
https://doi.org/10.1038/35050116
https://doi.org/10.1038/35050116
Publikováno v:
Behavior Genetics. 29:177-185
Mutations in the amyloid precursor protein (mAPP) and in presenilin 1 (mPS1) have both been linked to increased production of the β-amyloid peptide (Aβ). Doubly transgenic mice produced by mating of a parental line carrying the “Swedish” (K670N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fade8f401cfe07e5d17e98124f3d3bdc
https://doi.org/10.1023/a:1021691918517
https://doi.org/10.1023/a:1021691918517