Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Paul T. Bremer"'
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The opioid crisis in the United States is primarily driven by the highly potent synthetic opioid fentanyl leading to >70,000 overdose deaths annually; thus, new therapies for fentanyl overdose are urgently needed. Here, we present the first
Externí odkaz:
https://doaj.org/article/c1ac53ecc4b7482e8161a571ccad9b83
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Central Nervous System Pharmacology - Behavioral.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13b0ceb2382709944b1cba9c216f8875
https://doi.org/10.1124/jpet.122.166800
https://doi.org/10.1124/jpet.122.166800
Publikováno v:
ASPET 2023 Annual Meeting Abstract - Drug Discovery and Development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1549e4906931dbd6e562476c92c20c87
https://doi.org/10.1124/jpet.122.243100
https://doi.org/10.1124/jpet.122.243100
Autor:
Beverly A. Ellis, Kim D. Janda, Lisa M. Eubanks, Steven Blake, Yoshihiro Natori, Paul T. Bremer
Publikováno v:
ACS Chem Biol
The opioid epidemic remains a dire public health crisis with millions of people currently suffering from opioid use disorder (OUD) and tens of thousands dying each year. Synthetic opioids are most responsible for the crisis because of their extreme p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1cf7e91d7d81d24794c8aadc4e89bd
https://doi.org/10.1021/acschembio.1c00026
https://doi.org/10.1021/acschembio.1c00026
Autor:
Nikolai Petrovsky, Kim D. Janda, Bin Zhou, Steven Blake, Candy S. Hwang, Lauren C. Smith, Paul T. Bremer
Publikováno v:
Mol Pharm
The near insurmountable adversity that accompanies opioid use disorder (OUD) creates life-altering complications for opioid users. To worsen matters, existing small molecule drugs continue to inadequately address OUD due to their engagement of the op
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e634763fe7d5fc595c8d5d33d4f3efa3
https://doi.org/10.1021/acs.molpharmaceut.0c00837
https://doi.org/10.1021/acs.molpharmaceut.0c00837
Publikováno v:
J Am Chem Soc
The United States is in the midst of an unprecedented epidemic of opioid substance use disorder and while pharmacotherapies including opioid agonists and antagonists have shown success, they can be inadequate and frequently result in high recidivism.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8f014df5c9ba2faa2d609fb6b7f85a
https://doi.org/10.1021/jacs.0c05219
https://doi.org/10.1021/jacs.0c05219
Autor:
Paul T. Bremer, Hannah L. Robinson, S. Stevens Negus, Kaycee E. Faunce, Matthew L. Banks, Alaina M Jaster, Kim D. Janda, E. Andrew Townsend
Publikováno v:
ACS Chem Neurosci
Opioid-targeted vaccines represent an emerging treatment strategy for opioid use disorder. To determine whether concurrent vaccination against two commonly abused opioids (fentanyl and heroin) would confer broader spectrum opioid coverage, the curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82c9fed41a965635454742a1ba4010d7
https://doi.org/10.1021/acschemneuro.0c00064
https://doi.org/10.1021/acschemneuro.0c00064
Autor:
Bin Zhou, Paul T. Bremer, Beverly A. Ellis, Kim D. Janda, Lauren C. Smith, Mark S. Hixon, Candy S. Hwang
Publikováno v:
Journal of the American Chemical Society. 141:10489-10503
Opioid abuse in the United States has been declared a national crisis and is exacerbated by an inexpensive, readily available, and illicit supply of synthetic opioids. Specifically, fentanyl and related analogues such as carfentanil pose a significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7678a4a68bbaea062a1b3f08db839ebb
https://doi.org/10.1021/jacs.9b04872
https://doi.org/10.1021/jacs.9b04872
Autor:
Kim D. Janda, Kaycee E. Faunce, Steven Blake, Paul T. Bremer, Matthew L. Banks, Bin Zhou, Candy S. Hwang, Yoshihiro Natori, E. Andrew Townsend
Publikováno v:
Neuropsychopharmacology. 44:1681-1689
The current opioid crisis remains a significant public health issue and there is a critical need for biomedical research to develop effective and easily deployable candidate treatments. One emerging treatment strategy for opioid use disorder includes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a431d460c15cc79ad0a37ccaca32176d
https://doi.org/10.1038/s41386-019-0385-9
https://doi.org/10.1038/s41386-019-0385-9
Autor:
Paul T. Bremer, Kim D. Janda
Publikováno v:
Pharmacological Reviews. 69:298-315
Substance use disorder, especially in relation to opioids such as heroin and fentanyl, is a significant public health issue and has intensified in recent years. As a result, substantial interest exists in developing therapeutics to counteract the eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c88c3f2fca1ad0a824166ee1877c636e
https://doi.org/10.1124/pr.117.013904
https://doi.org/10.1124/pr.117.013904