Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Paul T. Kotzbauer"'
Autor:
Dhruva D. Dhavale, Alexander M. Barclay, Collin G. Borcik, Katherine Basore, Deborah A. Berthold, Isabelle R. Gordon, Jialu Liu, Moses H. Milchberg, Jennifer Y. O’Shea, Michael J. Rau, Zachary Smith, Soumyo Sen, Brock Summers, John Smith, Owen A. Warmuth, Richard J. Perrin, Joel S. Perlmutter, Qian Chen, James A. J. Fitzpatrick, Charles D. Schwieters, Emad Tajkhorshid, Chad M. Rienstra, Paul T. Kotzbauer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation of alpha-synuclein (Asyn) fibrils in Lewy bodies and Lewy neurites. Here we develop and validate a method to amplify Asyn fibrils extracted from
Externí odkaz:
https://doaj.org/article/34678621ec164ec7a36f533a9c6f2b2a
Autor:
Rebecca L. Miller, Dhruva D. Dhavale, Jennifer Y. O’Shea, Kristin M. Andruska, Jialu Liu, Erin E. Franklin, Chandana Buddhala, Susan K. Loftin, John R. Cirrito, Richard J. Perrin, Nigel J. Cairns, Meghan C. Campbell, Joel S. Perlmutter, Paul T. Kotzbauer
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 9, Iss 2, Pp 106-121 (2022)
Abstract Objective Parkinson disease (PD) is defined by the accumulation of misfolded α‐synuclein (α‐syn) in Lewy bodies and Lewy neurites. It affects multiple cortical and subcortical neuronal populations. The majority of people with PD develo
Externí odkaz:
https://doaj.org/article/5d4c609a4ab746119c1a7b2d88db2bf2
Autor:
W. R. Wayne Martin, John R. Younce, Meghan C. Campbell, Brad A. Racette, Scott A. Norris, Mwiza Ushe, Susan Criswell, Albert A. Davis, Isabel Alfradique‐Dunham, Baijayanta Maiti, Nigel J. Cairns, Richard J. Perrin, Paul T. Kotzbauer, Joel S. Perlmutter
Publikováno v:
Annals of Neurology. 93:184-195
The objective of this study was to evaluate the relationship between Parkinson's disease (PD) with dementia and cortical proteinopathies in a large population of pathologically confirmed patients with PD.We reviewed clinical data from all patients wi
Autor:
Alexander M. Barclay, Dhruva D. Dhavale, Collin G. Borcik, Moses H. Milchberg, Paul T. Kotzbauer, Chad M. Rienstra
Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be0010cb32901eaae13812b09162837e
https://doi.org/10.21203/rs.3.rs-2460685/v1
https://doi.org/10.21203/rs.3.rs-2460685/v1
13C and15N Resonance Assignments of Alpha Synuclein Fibrils Amplified from Lewy Body Dementia Tissue
Autor:
Alexander M. Barclay, Dhruva D. Dhavale, Collin G. Borcik, Moses H. Milchberg, Paul T. Kotzbauer, Chad M. Rienstra
Fibrils of the protein α-synuclein (Asyn) are implicated in the pathogenesis of Parkinson Disease, Lewy Body Dementia, and Multiple System Atrophy. Numerous forms of Asyn fibrils have been studied by solid-state NMR and resonance assignments have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f3486487f4dfaed3582efe499cf3da43
https://doi.org/10.1101/2023.01.09.523339
https://doi.org/10.1101/2023.01.09.523339
Autor:
Dhruva D. Dhavale, Alexander M. Barclay, Collin G. Borcik, Katherine Basore, Isabelle R. Gordon, Jialu Liu, Moses H. Milchberg, Jennifer O’shea, Michael J. Rau, Zachary Smith, Soumyo Sen, Brock Summers, John Smith, Owen A. Warmuth, Qian Chen, James A. J. Fitzpatrick, Charles D. Schwieters, Emad Tajkhorshid, Chad M. Rienstra, Paul T. Kotzbauer
Publikováno v:
bioRxiv
The defining feature of Parkinson disease (PD) and Lewy body dementia (LBD) is the accumulation of alpha-synuclein (Asyn) fibrils in Lewy bodies and Lewy neurites. We developed and validated a novel method to amplify Asyn fibrils extracted from LBD p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0029ccdc5a8007d47e24b582faaa71fb
https://doi.org/10.1101/2023.01.09.523303
https://doi.org/10.1101/2023.01.09.523303
Autor:
Nigel J. Cairns, W.R. Wayne Martin, Michael Miles, Paul T. Kotzbauer, Albert A. Davis, Brad A. Racette, Richard J. Perrin, Joel S. Perlmutter, Susan R. Criswell, Johanna M Hartlein, Mwiza Ushe, Baijayanta Maiti, Scott A. Norris, Qiaonan Zhong
Publikováno v:
Mov Disord
Background The clinical diagnosis of Parkinson's disease (PD) requires the presence of parkinsonism and supportive criteria that include a clear and dramatic beneficial response to dopaminergic therapy. Our aim was to test the diagnostic criterion of
Autor:
Randall J. Bateman, Nicolas R. Barthélemy, William Lu, Paul T. Kotzbauer, Haiyan Liu, Brendan P. Lucey
Publikováno v:
Ann Neurol
Tau hyperphosphorylation is an early step in tau-mediated neurodegeneration and is associated with intracellular aggregation of tau as neurofibrillary tangles, neuronal and synaptic loss, and eventual cognitive dysfunction in Alzheimer disease. Sleep
Autor:
Peter S. Myers, John L. O'Donnell, Joshua J. Jackson, Christina N. Lessov-Schlaggar, Rebecca L. Miller, Erin R. Foster, Carlos Cruchaga, Bruno A. Benitez, Paul T. Kotzbauer, Joel S. Perlmutter, Meghan C. Campbell
Publikováno v:
Neurology
Background and ObjectivesPeople with Parkinson disease (PD) commonly experience cognitive decline, which may relate to increased α-synuclein, tau, and β-amyloid accumulation. This study examines whether the different proteins predict longitudinal c
Autor:
Jessica N. Patterson, Sara K. Pittman, Yuna M. Ayala, Jan Bieschke, Paul T. Kotzbauer, Mohamed Salman Kaleelurrrahuman, William J. Buscher, Dhruva Dhavale, Conrad C. Weihl, Yuanzi Sun, Albert A. Davis, Jiang Zhu, Rachel L. French
Background: Neuronal uptake and subsequent spread of proteopathic seeds, such as αS (alpha-synuclein), tau, and TDP-43, contribute to neurodegeneration and disease progression. The cellular machinery necessary for this process is poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed2c9ab2ae6c2ddebc252e0e57da8e8
https://doi.org/10.1101/2021.07.12.452081
https://doi.org/10.1101/2021.07.12.452081