Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Paul T Marcyk"'
Autor:
Lauren E. Brown, Scott Seitz, Ashley V. Kondas, Paul T. Marcyk, Claire Marie Filone, Mohammad M. Hossain, Scott E. Schaus, Victoria A. Olson, John H. Connor
Publikováno v:
Antimicrob Agents Chemother
The genus Orthopoxvirus contains several human pathogens, including vaccinia, monkeypox, cowpox, and variola virus, the causative agent of smallpox. Although there are a few effective vaccines, widespread prophylactic vaccination has ceased and is un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef2633e3c77b814c2f192db9cecd53e
https://doi.org/10.1128/aac.00841-22
https://doi.org/10.1128/aac.00841-22
Autor:
Silas P. Cook, Paul T. Marcyk
Publikováno v:
Org Lett
Rapid assembly of saturated nitrogen hetero-cycles—the synthetically more challenging variants of their aromatic relatives—can expedite the synthesis of biologically relevant molecules. Starting from a benzylic alcohol tethered to an unactivated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eafec706269eb71c1db639766e2bcda3
https://doi.org/10.1021/acs.orglett.9b02353
https://doi.org/10.1021/acs.orglett.9b02353
Autor:
Tristan M G Kenney, Douglas A. Kuntz, Luke Whitesell, Paul T Marcyk, Alice Xue, Gilbert G. Privé, Emmanuelle V. LeBlanc, Noelle S. Williams, Lauren E. Brown, Stephen Bengtson, David S. Huang, Leah E. Cowen, Richard Trilles, Francisco Ortiz, Nicole Robbins, Damian J. Krysan
Publikováno v:
J Med Chem
The essential eukaryotic chaperone Hsp90 regulates the form and function of diverse client proteins, many of which govern thermotolerance, virulence, and drug resistance in fungal species. However, use of Hsp90 inhibitors as antifungal therapeutics h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51437590f15295e1392ea1f21207b793
https://pubmed.ncbi.nlm.nih.gov/33444025
https://pubmed.ncbi.nlm.nih.gov/33444025
Autor:
Paul T. Marcyk, Latisha R. Jefferies, Deyaa I. AbuSalim, Maren Pink, Mu‐Hyun Baik, Silas P. Cook
Publikováno v:
Angewandte Chemie. 131:1741-1745
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b86c7e4fc0977adb250d106aa742ef1b
https://doi.org/10.1002/ange.201812894
https://doi.org/10.1002/ange.201812894
Autor:
Silas P. Cook, Latisha R. Jefferies, Mu-Hyun Baik, Deyaa I. AbuSalim, Paul T. Marcyk, Maren Pink
Publikováno v:
Angewandte Chemie International Edition. 58:1727-1731
The direct, catalytic substitution of unactivated alcohols remains an undeveloped area of organic synthesis. Moreover, catalytic activation of this difficult electrophile with predictable stereo-outcomes presents an even more formidable challenge. De
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0323802bfc81076512b87be709b9a2fb
https://doi.org/10.1002/anie.201812894
https://doi.org/10.1002/anie.201812894
Autor:
Silas P. Cook, Paul T. Marcyk
Publikováno v:
Organic letters. 21(5)
The hydrofunctionalization of alkenes, explored for over 100 years, offers the potential for a direct, atom-economical approach to value-added products. While thermodynamically favored, the kinetic barrier to such processes necessitates the use of ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4e00312895ec58c4e161cf55c0fef7
https://pubmed.ncbi.nlm.nih.gov/30789740
https://pubmed.ncbi.nlm.nih.gov/30789740