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Akademický článek
A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild‐to‐moderate Alzheimer's disease
Autor: Pradeep J. Nathan, S. Babli Millais, Alex Godwood, Odile Dewit, David M. Cross, Janet Liptrot, Bharat Ruparelia, Stephen Paul Jones, Geor Bakker, Paul T. Maruff, Gregory A. Light, Alastair J.H. Brown, Malcolm Peter Weir, Miles Congreve, Tim Tasker
Publikováno v: Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild‐to‐moderate Alzheimer's disease (AD) on background donepezil 10 mg/day. M
Externí odkaz: https://doaj.org/article/d2ea8035b82442a48e018eec2348acbe
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8
A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M
Autor: Pradeep J, Nathan, S Babli, Millais, Alex, Godwood, Odile, Dewit, David M, Cross, Janet, Liptrot, Bharat, Ruparelia, Stephen Paul, Jones, Geor, Bakker, Paul T, Maruff, Gregory A, Light, Alastair J H, Brown, Malcolm Peter, Weir, Miles, Congreve, Tim, Tasker
Publikováno v: Alzheimer'sdementia (New York, N. Y.). 8(1)
This study examined the safety and pharmacodynamic effects of selective muscarinic MA randomized, double-blind, placebo-controlled 4-week safety study of HTL0018318 with up-titration and maintenance phases, observing exploratory effects on electrophy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ad0c05b300f87c734f6afd7887305f6d
https://pubmed.ncbi.nlm.nih.gov/35229025
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