Výsledky vyhledávání - "Paul Szmitko"

Heat-directed suicide gene therapy for breast cancer

Autor: Paul Szmitko, Duc Ngo, Fei-Fei Liu, Henry J. Klamut, Anthony Brade

Publikováno v: Cancer Gene Therapy. 10:294-301

Adjuvant hyperthermia can improve treatment outcome for locally recurrent breast cancer (LRBC). Previously, we demonstrated that infection of human breast cancer cells with a recombinant adenovirus expressing beta-galactosidase from the human hsp70b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c03f4cf1498ab06d0ebea501f4439c
https://doi.org/10.1038/sj.cgt.7700570

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Heat-directed gene targeting of adenoviral vectors to tumor cells

Autor: Henry J. Klamut, Anthony Brade, Pei-Xiang Li, Fei-Fei Liu, Paul Szmitko, Duc Ngo

Publikováno v: Cancer Gene Therapy. 7:1566-1574

Targeting therapeutic gene expression to tumor cells represents a major challenge for cancer gene therapy. The strong transcriptional response exhibited by heat shock genes, along with the beneficial therapeutic effects of hyperthermia have led us to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0649ef65032de60514c041c3679431
https://doi.org/10.1038/sj.cgt.7700267

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Kinase-dead PKB gene therapy combined with hyperthermia for human breast cancer

Autor: Nancy Ma, Paul Szmitko, Alex Lo, Fei-Fei Liu, James R. Woodgett, Anthony Brade, Isabel Chu, Henry J. Klamut

Publikováno v: Cancer gene therapy. 11(1)

We have previously demonstrated that protein kinase B (PKB) is a mediator of heat-induced apoptosis for human breast cancer cells. To investigate the therapeutic potential of abrogating the function of this important survival protein, a novel replica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416a3566a374c45532dfa4b8a0fc3d27
https://pubmed.ncbi.nlm.nih.gov/14681726

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Heat-directed tumor cell fusion

Autor: Fei-Fei Liu, Anthony Brade, Henry J. Klamut, Paul Szmitko, Duc Ngo

Publikováno v: Human gene therapy. 14(5)

In previous studies we demonstrated that a modified human HSP70b promoter (HSE.70b) directs high levels of gene expression to tumor cells after mild hyperthermia treatment in the range of 41.5-44 degrees C. This transcriptional targeting system exhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f39eb32078cb8949fca1f1aec15ee9f5
https://pubmed.ncbi.nlm.nih.gov/12691610

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Akademický článek

Heat-Directed Tumor Cell Fusion.

Autor: Anthony M. Brade, Paul Szmitko, Duc Ngo, Fei-Fei Liu, Henry J. Klamut

Publikováno v: Human Gene Therapy; 3/20/2003, Vol. 14 Issue 5, p447-461, 15p

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