Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Paul Stupple"'
Autor:
Melanie de Silva, Stewart D. Nuttall, Chen Fang Weng, Bin Ren, Paul Stupple, Mark A. Dawson, Annabelle Hoegl, Tim Thomas, Kathy Knezevic, Ian P. Street, George S. Vassiliou, Catalina Carrasco-Pozo, Yuqing Yang, Marnie E. Blewitt, Tracy A. Willson, Christopher J. Burns, Kah Lok Chan, Juliana Anokye, Linden J. Gearing, Thomas S. Peat, Janet Newman, Olan Dolezal, Oliver M. Dovey, Regina Surjadi, Miriam S. Butler, Laura MacPherson, Paul Yeh, Vicky M. Avery, Jonathan B. Baell, Enid Y.N. Lam, Yuxin Sun, Anne K. Voss, Nghi H. Nguyen, Ming Zhang, Matthew L. Dennis, Hendrik Falk, Rebecca A. Bilardi, Poh Sim Khoo, Marian L. Burr, Brendon J. Monahan, Miriam M. Yeung, Jarny Choi, Yih-Chih Chan, Chunaram Choudhary, Florian Grebien, Sarah-Jane Dawson, Joy Liu, David J. Leaver
Publikováno v:
MacPherson, L, Anokye, J, Yeung, M M, Lam, E Y N, Chan, Y-C, Weng, C-F, Yeh, P, Knezevic, K, Butler, M S, Hoegl, A, Chan, K-L, Burr, M L, Gearing, L J, Willson, T, Liu, J, Choi, J, Yang, Y, Bilardi, R A, Falk, H, Nghi Nguyen, Stupple, P A, Peat, T S, Zhang, M, De Silva, M, Carrasco-Pozo, C, Avery, V M, Khoo, S, Dolezal, O, Dennis, M L, Nuttall, S, Surjadi, R, Newman, J, Ren, B, Leaver, D J, Sun, Y, Baell, J B, Dovey, O, Vassiliou, G S, Grebien, F, Dawson, S-J, Street, I P, Monahan, B J, Burns, C J, Choudhary, C, Blewitt, M E, Voss, A K, Thomas, T & Dawson, M A 2020, ' HBO1 is required for the maintenance of leukaemia stem cells ', Nature, vol. 577, no. 7789, pp. 266-270 . https://doi.org/10.1038/s41586-019-1835-6
Acute myeloid leukaemia (AML) is a heterogeneous disease characterized by transcriptional dysregulation that results in a block in differentiation and increased malignant self-renewal. Various epigenetic therapies aimed at reversing these hallmarks o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3bc6f449feaabadd1fab4f6f8e7cdc
Autor:
Karen L. White, Sean Uryu, Pei-Pei Kung, Melanie de Silva, Ian P. Street, Hieu Lam, Jane E. Visvader, Ylva E. Bozikis, Catalina Carrasco-Pozo, Karen A. Maegley, Geoffrey J. Lindeman, Shikhar Sharma, Anne K. Voss, Paul Stupple, Natalie Nady, Elizabeth Allan, Olan Dolezal, Chin Wee Tan, Elliot Surgenor, Yong Zhang, Alexandra E. Stupple, Yuqing Yang, Amanda Rickard, Michelle Ang Camerino, Brendon J. Monahan, Showkhin Khan, Thomas A Paul, Hendrik Falk, François Vaillant, Laura MacPherson, Zhenxiong Wang, Dawson Sarah-Jane, James R. Whittle, Jay Chung, Melissa J. Davis, Mark A. Dawson, Eric Greenwald, Thomas S. Peat, Vicky M. Avery, Tim Thomas, Haikuo Zhang, Rachel Lagiakos, Patrick Bingham, Matthew L. Dennis, Bin Ren, Miriam S. Butler, Susan A. Charman, Soroor Hediyeh-Zadeh, Stewart D. Nuttall
Publikováno v:
Cancer Research. 81:1130-1130
KAT6A is a lysine histone acetyltransferase (HAT) of the MYST family of HATs. KAT6A, and its paralog KAT6B, have been shown to acetylate histone H3K23Ac and regulate diverse biological processes, including transcription, cell-cycle progression, stem
Autor:
Paul Stupple, Deborah A. Knight, Ian P. Street, Isabella Y. Kong, Sarah Jones, Ylva Elisabet Bergman, Hendrik Falk, Philip D. Hodgkin, Joel S. Rimes, Edwin D. Hawkins, Stephin J. Vervoort, Eric F Morand, Ricky W. Johnstone, Brendon J. Monahan, Philippe Bouillet, Izabela Todorovski, Susanne Heinzel, Amanda Light, Simon J. Hogg
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108290-(2020)
Summary: JQ1 is a BET-bromodomain inhibitor that has immunomodulatory effects. However, the precise molecular mechanism that JQ1 targets to elicit changes in antibody production is not understood. Our results show that JQ1 induces apoptosis, reduces
Autor:
Ian P. Street, Alexandra E. Stupple, Thomas S. Peat, Brendon J. Monahan, Matthew L. Dennis, Paul Stupple, Benjamin Joseph Morrow, Olan Dolezal, Richard C. Foitzik, Meghan Hattarki, Stewart D. Nuttall, Anthony N Cuzzupe, Janet Newman, John D. Bentley
Publikováno v:
Structural Dynamics, Vol 6, Iss 6, Pp 064701-064701-20 (2019)
Structural Dynamics
Structural Dynamics
The WD40-repeat protein WDR5 scaffolds various epigenetic writers and is a critical component of the mammalian SET/MLL histone methyltransferase complex. Dysregulation of the MLL1 catalytic function is associated with mixed-lineage leukemia, and anta
Autor:
Ian P. Street, Nicholas C. Wong, Andrew H. Wei, Rachel Altura, David J. Curtis, Feng Yan, Andrej Terzic, Stefan Eugen Sonderegger, Stephen M. Jane, Paul Stupple, Benjamin Nicholson, Emma Toulmin, Loretta Cerruti
Publikováno v:
Blood. 132:4061-4061
Background: Targeting leukemic stem cells without detrimental effects on hematopoietic stem cells is a major goal for improving cure rates for acute myeloid leukemia (AML). Strategies include targeting leukemia specific mutations or pathways where le
Autor:
Ian P. Street, David J. Curtis, Paul Stupple, Stephen M. Jane, Benjamin Nicholson, Loretta Cerruti, Cedric S. Tremblay, Stefan Eugen Sonderegger, Emma Toulmin, Tom Nebl, Hendrik Falk, Katherine M. Hannan, Ashwin Unnikrishnan, Jesslyn Saw, Steven W. Lane, Rachel Altura
Publikováno v:
Blood. 132:53-53
Background: Myeloproliferative neoplasms (MPN) are a diverse group of hematopoietic stem cell disorders. JAK2V617F gain-of-function is the most prevalent mutation, accounting for more than 60% of MPNs. PRMT5 was initially identified as a JAK-binding
Autor:
Paul Stupple, Ian P. Street, Janet Newman, Ben Morrow, Matthew L. Dennis, Poh Sim Khoo, Olan Dolezal, Thomas S. Peat, Brendon J. Monahan, Richard C. Foitzik
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 74:a139-a139
Autor:
Michael W. Parker, Susan A. Charman, Stefan Eugen Sonderegger, Ian Holmes, Wilco Kersten, Hendrik Falk, Ian P. Street, Elizabeth Allan, Scott E. Walker, Richard C. Foitzik, Kurt Lackovic, Ylva Elisabet Bergman, Alison Gregg, Thomas S. Peat, Brendon J. Monahan, Yuen Tan, Julian Grusovin, Quan Zhao, M.C. Chung, Marcia Nikac, Michelle Ang Camerino, Kym N Lowes, Paul Stupple, Pat Pilling, David J. Curtis, Stephen M. Jane, Jo Alcindor
Publikováno v:
Blood. 120:2129-2129
Abstract 2129 The developmental switch in human β-like globin gene subtype from fetal (γ) to adult (β) that begins at birth foreshadows the onset of the hemoglobinopathies, β-thalassemia and sickle cell disease (SCD). In the clinical setting it i