Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Paul Sopp"'
Autor:
Emily M. Randall, Paul Sopp, Anna Raper, Inga Dry, Tom Burdon, Jayne C. Hope, Lindsey A. Waddell
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Bovine alveolar macrophages (AMs) defend the lungs against pathogens such as Mycobacterium bovis (M. bovis), the causative agent of bovine tuberculosis. However, little is known about the surface molecules expressed by bovine AMs and whether
Externí odkaz:
https://doaj.org/article/9d805f08c2534f1cb1610ca379492d1e
Autor:
Zixi Yin, Ji-Li Chen, Yongxu Lu, Beibei Wang, Leila Godfrey, Alexander J. Mentzer, Xuan Yao, Guihai Liu, Dannielle Wellington, Yiqi Zhao, Peter A.C. Wing, Wanwisa Dejnirattisa, Piyada Supasa, Chang Liu, Philip Hublitz, Ryan Beveridge, Craig Waugh, Sally-Ann Clark, Kevin Clark, Paul Sopp, Timothy Rostron, Juthathip Mongkolsapaya, Gavin R. Screaton, Graham Ogg, Katie Ewer, Andrew J. Pollard, Sarah Gilbert, Julian C. Knight, Teresa Lambe, Geoffrey L. Smith, Tao Dong, Yanchun Peng
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112470- (2023)
Summary: Most existing studies characterizing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific T cell responses are peptide based. This does not allow evaluation of whether tested peptides are processed and presented canonically.
Externí odkaz:
https://doaj.org/article/3206b4dffaab4738b6d887ce4a473de9
Autor:
Hedia Chagraoui, Maiken S. Kristiansen, Juan Pablo Ruiz, Ana Serra-Barros, Johanna Richter, Elisa Hall-Ponselé, Nicki Gray, Dominic Waithe, Kevin Clark, Philip Hublitz, Emmanouela Repapi, Georg Otto, Paul Sopp, Stephen Taylor, Supat Thongjuea, Paresh Vyas, Catherine Porcher
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Mechanisms that operate during embryonic development to restrict cell fate are currently under investigation. Here the authors characterise the role of SCL/TAL1 at the onset of blood specification in embryonic development using mouse EB differentiati
Externí odkaz:
https://doaj.org/article/58afad89e66d460dbd6feaaa3566ef20
Autor:
Sachith Mettananda, Chris A. Fisher, Deborah Hay, Mohsin Badat, Lynn Quek, Kevin Clark, Philip Hublitz, Damien Downes, Jon Kerry, Matthew Gosden, Jelena Telenius, Jackie A. Sloane-Stanley, Paula Faustino, Andreia Coelho, Jessica Doondeea, Batchimeg Usukhbayar, Paul Sopp, Jacqueline A. Sharpe, Jim R. Hughes, Paresh Vyas, Richard J. Gibbons, Douglas R. Higgs
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
β-thalassemia is characterised by the presence of an excess of α-globin chains, which contribute to erythrocyte pathology. Here the authors use CRISP/Cas9 to reduce α-globin expression in hematopoietic precursors, and show effectiveness in xenogra
Externí odkaz:
https://doaj.org/article/0cd23b9b09ec4af18f7d483a67ceba18
Autor:
Xi Li, Rouzheng Wang, Peiwen Fan, Xuan Yao, Ling Qin, Yanchun Peng, Miaomiao Ma, Neil Asley, Xuimei Chang, Yaning Feng, Yunhui Hu, Yonghong Zhang, Chris Li, Gregory Fanning, Stephanie Jones, Clare Verrill, David Maldonado-Perez, Paul Sopp, Craig Waugh, Stephen Taylor, Simon Mcgowan, Vincenzo Cerundolo, Christopher Conlon, Andrew McMichael, Shichun Lu, Xiyan Wang, Ning Li, Tao Dong
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Background: Cancer patients often display dysfunctional antitumor T-cell responses. Because noteworthy benefits of immune checkpoint pathway blockade, such as programmed cell death protein 1 (PD-1) inhibitors, have been achieved in multiple advanced
Externí odkaz:
https://doaj.org/article/772c0dafccf74a729e4b3727ac88843d
Autor:
Sven Turkalj, Niels Asger Jakobsen, Angus Groom, Marlen Metzner, Batchimeg Usukhbayar, Mirian Angulo Salazar, Kevin Clark, E. Ravza Gür, Lance D. Hentges, Paul Sopp, James O.J. Davies, Jim R. Hughes, Paresh Vyas
Publikováno v:
Blood. 140:1193-1194
Autor:
Christina Dold, Mariolina Salio, John Frater, Peter Simmonds, Christopher P. Conlon, J Slon-Campos, Z Yin, David I. Stuart, N F Schwabe, Guido C. Paesen, D Dong, Richard J. Cornall, Paul Thomson, T Lockett, Oliver W. Bayfield, U S Rajapaksa, J W Fry, P Supasa, Jonathan M. Grimes, R Levin, Wanwisa Dejnirattisai, Graham S. Ogg, Dannielle Wellington, Openshaw Pjm., Chen Y-L., Hawkins Dedp., P Zhang, Giorgio Napolitani, Tao Dong, J K Baillie, C Liu, Cesar Lopez-Camacho, Paul Sopp, M A Ansari, Alfred A. Antson, Ker D-S., Persephone Borrow, Susanna Dunachie, Andrew J. McMichael, Juthathip Mongkolsapaya, Yanchun Peng, B Wang, T Rostron, Shona C Moore, Lance Turtle, G Liu, T I de Silva, Krishanthi Subramaniam, Jeremy Ratcliff, Ho L-P., Benedikt M. Kessler, G Kerr, Yuguang Zhao, X Yao, Malcolm G Semple, Gavin R. Screaton, Paul Klenerman, Wayne Paes, R Jing, Alexander J. Mentzer, Y Zhang, Philip J. R. Goulder, Eleanor Barnes, Julian C. Knight
Publikováno v:
Nature Immunology
NATURE IMMUNOLOGY
Nat Immunol
NATURE IMMUNOLOGY
Nat Immunol
The development of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines and therapeutics will depend on understanding viral immunity. We studied T cell memory in 42 patients following recovery from COVID-19 (28 with mild disease and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f78680cf7c854968fa13a2ef61dd0a2
https://ora.ox.ac.uk/objects/uuid:e5e926ec-b256-4608-9956-84db12d56741
https://ora.ox.ac.uk/objects/uuid:e5e926ec-b256-4608-9956-84db12d56741
Autor:
Tao Dong, Guihai Liu, Suet Felce, Xuan Yao, Zixi Yin, Anastasia Fries, Alexander Mentzer, Danning Dong, Wenbo Wang, Wanwisa Dejnirattisai, Piyada Supasa, Chang Liu, Peter Wing, Timothy Rostron, Craig Waugh, Sally-Ann Clark, Kevin Clark, Paul Sopp, Philip Hublitz, Ryan Beveridge, Jeremy Fry, Jane McKeating, Juthathip Mongkolsapaya, Gavin Screaton, Graham Ogg, Julian Knight, Yanchun Peng
Little is known of the role of cytotoxic CD4+ T-cells in the control of viral replication. Here, we investigate CD4+ T-cell responses to three dominant SARS-CoV-2 epitopes and evaluate antiviral activity, including cytotoxicity and antiviral cytokine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb6d7b664e3d46e6705f28f1fe1dab4d
https://doi.org/10.21203/rs.3.rs-1317569/v1
https://doi.org/10.21203/rs.3.rs-1317569/v1
Autor:
Tao Dong, Graham Ogg, Yan-Chun Peng, Suet Felce, Danning Dong, Frank Penkava, Alexander Mentzer, Xuan Lao, Guihai Liu, Zixi Yin, Ji-Li Chen, YongXu Lu, Dannielle Wellington, Peter Wing, Delaney Dominey-Foy, Julian Knight, Chen Jin, Wenbo Wang, Megat Abd Hamid, Ricardo Fernandes, Beibei Wang, Anastasia Fries, Xiaodong Zhuang, Neil Ashley, Timothy Rostron, Craig Waugh, Paul Sopp, Philip Hublitz, Ryan Beveridge, Tiong Kit Tan, Christina Dold, Andrew Kwok, Charlotte Rich-Griffin, Wanwisa Dejnirattisai, Isar Nassiri, Robert Watson, Orion Tong, Chelsea Taylor, Piyush Kumar Sharma, Fabiola Curion, Santiago Revale, Lucy Garner, Kathrin Jansen, Ricardo Ferreira, Moustafa Attar, Jeremy Fry, Rebecca Russell, Hans Stauss, William James, Alain Townsend, Ling-Pei Ho, Juthathip Mongkolsapaya, Paul Klenerman, Gavin Screaton, Calliope Dendrou, Stephen Sansom, Rachael Bashford-Rogers, Benny Chain, Geoffrey Smith, Jane McKeating, Benjamin Fairfax, Paul Bowness, Andrew McMichael
NP105-113-B*07:02 specific CD8+ T-cell responses are considered among the most dominant in SARS-CoV-2-infected individuals. We found strong association of this response with mild disease. Analysis of NP105-113-B*07:02 specific T-cell clones and singl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::167f2ea271cbc55149a70fe16ddbea87
https://doi.org/10.21203/rs.3.rs-734011/v1
https://doi.org/10.21203/rs.3.rs-734011/v1
Autor:
Yanchun, Peng, Suet Ling, Felce, Danning, Dong, Frank, Penkava, Alexander J, Mentzer, Xuan, Yao, Guihai, Liu, Zixi, Yin, Ji-Li, Chen, Yongxu, Lu, Dannielle, Wellington, Peter A C, Wing, Delaney C C, Dominey-Foy, Chen, Jin, Wenbo, Wang, Megat Abd, Hamid, Ricardo A, Fernandes, Beibei, Wang, Anastasia, Fries, Xiaodong, Zhuang, Neil, Ashley, Timothy, Rostron, Craig, Waugh, Paul, Sopp, Philip, Hublitz, Ryan, Beveridge, Tiong Kit, Tan, Christina, Dold, Andrew J, Kwok, Charlotte, Rich-Griffin, Wanwisa, Dejnirattisa, Chang, Liu, Prathiba, Kurupati, Isar, Nassiri, Robert A, Watson, Orion, Tong, Chelsea A, Taylor, Piyush, Kumar Sharma, Bo, Sun, Fabiola, Curion, Santiago, Revale, Lucy C, Garner, Kathrin, Jansen, Ricardo C, Ferreira, Moustafa, Attar, Jeremy W, Fry, Rebecca A, Russell, Hans J, Stauss, William, James, Alain, Townsend, Ling-Pei, Ho, Paul, Klenerman, Juthathip, Mongkolsapaya, Gavin R, Screaton, Calliope, Dendrou, Stephen N, Sansom, Rachael, Bashford-Rogers, Benny, Chain, Geoffrey L, Smith, Jane A, McKeating, Benjamin P, Fairfax, Paul, Bowness, Andrew J, McMichael, Graham, Ogg, Julian C, Knight, Tao, Dong
Publikováno v:
Nature immunology. 23(1)
NP