Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Paul Smolen"'
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Epidemiological studies have shown that traumatic brain injury (TBI) increases the risk for developing neurodegenerative diseases (NDs). However, molecular mechanisms that underlie this risk are largely unidentified. TBI triggers widespread epigeneti
Externí odkaz:
https://doaj.org/article/ce024d5057914c27bc82b4c8cc9e6128
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010239 (2022)
Key features of long-term memory (LTM), such as its stability and persistence, are acquired during processes collectively referred to as consolidation. The dynamics of biological changes during consolidation are complex. In adult rodents, consolidati
Externí odkaz:
https://doaj.org/article/ce84d98358414293bffdb05b0ef3b7f5
Publikováno v:
Frontiers in Computational Neuroscience, Vol 14 (2020)
A fundamental neuroscience question is how memories are maintained from days to a lifetime, given turnover of proteins that underlie expression of long-term synaptic potentiation (LTP) or “tag” synapses as eligible for LTP. A likely solution reli
Externí odkaz:
https://doaj.org/article/2f4683c890504b69a5524b7a8921b9f4
Autor:
Paul Smolen
Publikováno v:
Neural Plasticity, Vol 2015 (2015)
Memories are stored, at least partly, as patterns of strong synapses. Given molecular turnover, how can synapses maintain strong for the years that memories can persist? Some models postulate that biochemical bistability maintains strong synapses. Ho
Externí odkaz:
https://doaj.org/article/94e369a39e7a465bbb3d866839a7d1a0
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 3, p e1003524 (2014)
Cellular functions and responses to stimuli are controlled by complex regulatory networks that comprise a large diversity of molecular components and their interactions. However, achieving an intuitive understanding of the dynamical properties and re
Externí odkaz:
https://doaj.org/article/0ebbba3455604168b187c0abce408fb5
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 8, p e1002620 (2012)
Protein synthesis-dependent, late long-term potentiation (LTP) and depression (LTD) at glutamatergic hippocampal synapses are well characterized examples of long-term synaptic plasticity. Persistent increased activity of protein kinase M ζ (PKMζ) i
Externí odkaz:
https://doaj.org/article/413f7060356c40079dc452240b2e01ed
Autor:
Paul Smolen
Publikováno v:
PLoS ONE, Vol 2, Iss 5, p e445 (2007)
Late long-term potentiation (L-LTP) denotes long-lasting strengthening of synapses between neurons. L-LTP appears essential for the formation of long-term memory, with memories at least partly encoded by patterns of strengthened synapses. How memorie
Externí odkaz:
https://doaj.org/article/99a52a52d1e44d778ac33b5885fb2b2f
Publikováno v:
Learning & Memory. 29:435-446
Empirical and computational methods were combined to examine whether individual or dual-drug treatments can restore the deficit in long-term synaptic facilitation (LTF) of theAplysiasensorimotor synapse observed in a cellular model of Coffin–Lowry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e9abb4f78c84f076acc07b17501218
https://doi.org/10.1101/lm.053625.122
https://doi.org/10.1101/lm.053625.122
Autor:
Laura, Zima, Rebecca, West, Paul, Smolen, Nobuhide, Kobori, Georgene, Hergenroeder, HuiMahn A, Choi, Anthony N, Moore, John B, Redell, Pramod K, Dash
Publikováno v:
Journal of Neurotrauma. 39:1279-1288
Epigenetic information is not permanently encoded in the DNA sequence, but rather consists of reversible, heritable modifications that regulate the gene expression profile of a cell. Epigenetic modifications can result in cellular changes that can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d9ae2fcff9f67d6e7fcaf068c93e60
https://doi.org/10.1089/neu.2022.0128
https://doi.org/10.1089/neu.2022.0128
Mechanisms of specific memory deficits associated with Rett syndrome are poorly understood, at least in part because mutations ofMECP2have confounding effects on nervous system development and basal synaptic transmission. To mitigate such empirical u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a47ec652389e32cae90b49d23ad4b3d9
https://doi.org/10.1101/2022.10.25.513721
https://doi.org/10.1101/2022.10.25.513721
