Zobrazeno 1 - 10
of 131
pro vyhledávání: '"Paul Smolen"'
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
Epidemiological studies have shown that traumatic brain injury (TBI) increases the risk for developing neurodegenerative diseases (NDs). However, molecular mechanisms that underlie this risk are largely unidentified. TBI triggers widespread epigeneti
Externí odkaz:
https://doaj.org/article/ce024d5057914c27bc82b4c8cc9e6128
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010239 (2022)
Key features of long-term memory (LTM), such as its stability and persistence, are acquired during processes collectively referred to as consolidation. The dynamics of biological changes during consolidation are complex. In adult rodents, consolidati
Externí odkaz:
https://doaj.org/article/ce84d98358414293bffdb05b0ef3b7f5
Publikováno v:
Frontiers in Computational Neuroscience, Vol 14 (2020)
A fundamental neuroscience question is how memories are maintained from days to a lifetime, given turnover of proteins that underlie expression of long-term synaptic potentiation (LTP) or “tag” synapses as eligible for LTP. A likely solution reli
Externí odkaz:
https://doaj.org/article/2f4683c890504b69a5524b7a8921b9f4
Publikováno v:
Learning & Memory. 29:435-446
Empirical and computational methods were combined to examine whether individual or dual-drug treatments can restore the deficit in long-term synaptic facilitation (LTF) of theAplysiasensorimotor synapse observed in a cellular model of Coffin–Lowry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e9abb4f78c84f076acc07b17501218
https://doi.org/10.1101/lm.053625.122
https://doi.org/10.1101/lm.053625.122
Autor:
Laura, Zima, Rebecca, West, Paul, Smolen, Nobuhide, Kobori, Georgene, Hergenroeder, HuiMahn A, Choi, Anthony N, Moore, John B, Redell, Pramod K, Dash
Publikováno v:
Journal of Neurotrauma. 39:1279-1288
Epigenetic information is not permanently encoded in the DNA sequence, but rather consists of reversible, heritable modifications that regulate the gene expression profile of a cell. Epigenetic modifications can result in cellular changes that can be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4d9ae2fcff9f67d6e7fcaf068c93e60
https://doi.org/10.1089/neu.2022.0128
https://doi.org/10.1089/neu.2022.0128
Mechanisms of specific memory deficits associated with Rett syndrome are poorly understood, at least in part because mutations ofMECP2have confounding effects on nervous system development and basal synaptic transmission. To mitigate such empirical u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a47ec652389e32cae90b49d23ad4b3d9
https://doi.org/10.1101/2022.10.25.513721
https://doi.org/10.1101/2022.10.25.513721
Publikováno v:
Oxford Open Neuroscience. 2
Phosphorylation of the MAPK family member extracellular signal–regulated kinase (ERK) is required to induce long-term synaptic plasticity, but little is known about its persistence. We examined ERK activation by three protocols that induce long-ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7dc3fd04d282deba5003981367f4324
https://doi.org/10.1093/oons/kvac014
https://doi.org/10.1093/oons/kvac014
The mitogen-activated protein kinase (MAPK) isoform extracellular signal–regulated kinase (ERK) is a key kinase involved in the induction of long-term synaptic facilitation (LTF) of the Aplysia sensorimotor synapse. Therefore, elucidating the dynam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7100923b05d8fc5e8be057a61b3a3c5f
https://doi.org/10.1101/2022.08.05.502983
https://doi.org/10.1101/2022.08.05.502983
Autor:
Xu O. Zhang, Yili Zhang, Claire E. Cho, Douglas S. Engelke, Paul Smolen, John H Byrne, Fabricio H. Do-Monte
Learning requires the activation of protein kinases with distinct temporal dynamics. Nonassociative learning inAplysiacan be enhanced by a computationally designed learning protocol with intertrial intervals (ITIs) that maximize the interaction betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8bf32cc401db60ac0429955d90518a3
https://doi.org/10.1101/2022.06.08.495364
https://doi.org/10.1101/2022.06.08.495364
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Multiple kinases converge on the transcription factor cAMP response element-binding protein (CREB) to enhance the expression of proteins essential for long-term synaptic plasticity and memory. The p90 ribosomal S6 kinase (RSK) is one of these kinases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3d14864008ff24cb2b5a7dbe48c125c
http://link.springer.com/article/10.1038/s41598-020-57484-y
http://link.springer.com/article/10.1038/s41598-020-57484-y