Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Paul Schilf"'
Autor:
Michael Olbrich, Adina-Malin Hartmann, Sven Künzel, Zouhair Aherrahrou, Paul Schilf, John F. Baines, Saleh M. Ibrahim, Misa Hirose
Publikováno v:
Pharmacological Research, Vol 205, Iss , Pp 107231- (2024)
We previously demonstrated that mice carrying natural mtDNA variants of the FVB/NJ strain (m.7778 G>T in the mt-Atp8 gene in mitochondrial complex V), namely C57BL/6 J-mtFVB/NJ (B6-mtFVB), exhibited (i) partial protection from experimental skin infla
Externí odkaz:
https://doaj.org/article/1a81fe206ac04aa69c9a82cb18c3724c
Autor:
Reza Akbarzadeh, Christianna Czyz, Sarah-Yasmin Thomsen, Paul Schilf, Sripriya Murthy, Christian D. Sadik, Peter König
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Monocytes play a significant role in the pathogenesis of most inflammatory diseases, including autoimmune diseases. Herein, different subpopulations of monocytes often play differential, partially antagonistic roles, in the regulation of tissue popul
Externí odkaz:
https://doaj.org/article/0a01698cac274ab680b5a9ec355c255e
Autor:
Christian F. Guerrero-Juarez, Paul Schilf, Jing Li, Maria Paula Zappia, Lei Bao, Payal M. Patel, Jenny Gieseler-Tillmann, Sripriya Murthy, Connor Cole, Maria Sverdlov, Maxim V. Frolov, Takashi Hashimoto, Norito Ishii, Thomas Rülicke, Katja Bieber, Ralf J. Ludwig, Christian D. Sadik, Kyle T. Amber
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionInflammatory epidermolysis bullosa acquisita (EBA) is characterized by a neutrophilic response to anti-type VII collagen (COL7) antibodies resulting in the development of skin inflammation and blistering. The antibody transfer model of EB
Externí odkaz:
https://doaj.org/article/1405ecc563cf4c7cb34962308c3e35d5
Autor:
Artem Vorobyev, Yask Gupta, Tanya Sezin, Hiroshi Koga, Yannic C. Bartsch, Meriem Belheouane, Sven Künzel, Christian Sina, Paul Schilf, Heiko Körber-Ahrens, Foteini Beltsiou, Anna Lara Ernst, Stanislav Khil’chenko, Hassanin Al-Aasam, Rudolf A. Manz, Sandra Diehl, Moritz Steinhaus, Joanna Jascholt, Phillip Kouki, Wolf-Henning Boehncke, Tanya N. Mayadas, Detlef Zillikens, Christian D. Sadik, Hiroshi Nishi, Marc Ehlers, Steffen Möller, Katja Bieber, John F. Baines, Saleh M. Ibrahim, Ralf J. Ludwig
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Complex traits associate with genetic variation and environment and their interaction. Here, the authors study the influence of different diets on trait variability in 1154 outbred mice from an advanced intercross line and find gene-diet interactions
Externí odkaz:
https://doaj.org/article/33aa09018c92411598dc61043de133d0
Autor:
Vunnam Srinivasulu, Paul Schilf, Saleh Ibrahim, Monther A. Khanfar, Scott McN Sieburth, Hany Omar, Anusha Sebastian, Raed A. AlQawasmeh, Matthew John O’Connor, Taleb H. Al-Tel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Methods enabling the synthesis of diverse collections of nature-inspired compounds with potential medicinal use are sought after in drug design. Here, the authors report a build/couple/pair strategy to efficiently construct chiral polycyclic scaffold
Externí odkaz:
https://doaj.org/article/fe4e0908a13b4e04b9750d85006dd424
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1056 (2022)
We recently reported on two mouse strains carrying different single nucleotide variations in the mitochondrial complex I gene, i.e., B6-mtBPL mice carrying m.11902T>C and B6-mtALR carrying m.4738C>A. B6-mtBPL mice exhibited a longer lifespan and a lo
Externí odkaz:
https://doaj.org/article/024f21b64cc646f49a81aba55b75cad9
Autor:
Dana M. Zaher, Wafaa S. Ramadan, Raafat El-Awady, Hany A. Omar, Fatema Hersi, Vunnam Srinivasulu, Ibrahim Y. Hachim, Farah I. Al-Marzooq, Cijo G. Vazhappilly, Salim Merali, Carmen Merali, Nelson C. Soares, Paul Schilf, Saleh M. Ibrahim, Taleb H. Al-Tel
Publikováno v:
Cancers, Vol 13, Iss 11, p 2840 (2021)
(1) Background: Today, the discovery of novel anticancer agents with multitarget effects and high safety margins represents a high challenge. Drug discovery efforts indicated that benzopyrane scaffolds possess a wide range of pharmacological activiti
Externí odkaz:
https://doaj.org/article/652360809dfa4f7eb4bbc8d4ba4367af
Autor:
Paul Schilf, Axel Künstner, Michael Olbrich, Silvio Waschina, Beate Fuchs, Christina E. Galuska, Anne Braun, Kerstin Neuschütz, Malte Seutter, Katja Bieber, Lars Hellberg, Christian Sina, Tamás Laskay, Jan Rupp, Ralf J. Ludwig, Detlef Zillikens, Hauke Busch, Christian D. Sadik, Misa Hirose, Saleh M. Ibrahim
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3, p 1006 (2021)
Several genetic variants in the mitochondrial genome (mtDNA), including ancient polymorphisms, are associated with chronic inflammatory conditions, but investigating the functional consequences of such mtDNA polymorphisms in humans is challenging due
Externí odkaz:
https://doaj.org/article/b0d1238d6ae04171ab1689fb651047f6
Autor:
Misa Hirose, Paul Schilf, Kim Zarse, Hauke Busch, Georg Fuellen, Olaf Jöhren, Rüdiger Köhling, Inke R. König, Barbara Richer, Jan Rupp, Markus Schwaninger, Karsten Seeger, Christian Sina, Michael Ristow, Saleh M. Ibrahim
Publikováno v:
Genes, Vol 10, Iss 7, p 532 (2019)
Mitochondrial complex I—the largest enzyme complex of the mitochondrial oxidative phosphorylation machinery—has been proposed to contribute to a variety of age-related pathological alterations as well as longevity. The enzyme complex-consisting p
Externí odkaz:
https://doaj.org/article/0589b49b8a25435aab07f5330fbab6c3
Autor:
Misa Hirose, Axel Künstner, Paul Schilf, Anna Katharina Tietjen, Olaf Jöhren, Patricia Huebbe, Gerald Rimbach, Jan Rupp, Markus Schwaninger, Hauke Busch, Saleh M. Ibrahim
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2359 (2019)
In this study, we provide experimental evidence that a maternally inherited polymorphism in the mitochondrial cytochrome b gene (mt-Cytb; m.15124A>G, Ile-Val) in mitochondrial complex III resulted in middle-aged obesity and higher susceptibility to d
Externí odkaz:
https://doaj.org/article/3043b84b77174766b99c1d69387fc96c