Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Paul Sargeant"'
Autor:
Shaun Treweek, Ewan Pearson, Natalie Smith, Ron Neville, Paul Sargeant, Brian Boswell, Frank Sullivan
Publikováno v:
Journal of Innovation in Health Informatics, Vol 18, Iss 1, Pp 51-58 (2010)
Background Recruitment to trials in primary care is often difficult, particularly when practice staff need to identify study participants with acute conditions during consultations. The Scottish Acute Recruitment Management Application (SARMA) system
Externí odkaz:
https://doaj.org/article/74aac14bf88d4a858c076b487bb87337
Publikováno v:
Experimental Physiology. 79:269-272
The endomembrane Ca(2+)-ATPase inhibitor, thapsigargin, was used to deplete the intracellular Ca2+ stores of fura-2-loaded human platelets. In control cells, thapsigargin evoked a rise in cytosolic [Ca2+] and a substantial increase in protein tyrosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc0c24444af369b8e624ef1810932f3
https://doi.org/10.1113/expphysiol.1994.sp003762
https://doi.org/10.1113/expphysiol.1994.sp003762
Autor:
Stewart O. Sage, Philip G. Hargreaves, Paul Sargeant, Ellen F Licking, Mike Barnes, Richard W. Farndale
Publikováno v:
Thrombosis and Haemostasis. 72:634-642
SummaryWe have investigated the effects of the tyrosine kinase inhibitors, genistein and methyl 2,5-dihydroxycinnamate, on [3H]arachidonic acid release from human platelets. Both tyrosine kinase inhibitors blocked, in a dose-dependent manner, the rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b3853650268a86b803a1124238fdf33
https://doi.org/10.1055/s-0038-1648927
https://doi.org/10.1055/s-0038-1648927
Publikováno v:
Journal of Biological Chemistry. 268:18151-18156
We have investigated the mechanism of Ca2+ entry in fura-2-loaded human platelets using the inhibitors of tyrosine kinases, genistein, and methyl-2,5-dihydroxycinnamate. Genistein (100 microM; 30 min) or methyl-2,5-dihydroxycinnamate (1 microgram/ml;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::520e07dd8e1b664df4807035189f0623
https://doi.org/10.1016/s0021-9258(17)46823-2
https://doi.org/10.1016/s0021-9258(17)46823-2
Publikováno v:
FEBS Letters. 315:242-246
Platelet activation is associated with the phosphorylation of a number of platelet proteins at tyrosine residues. The significance of this is unknown. Here we have investigated the effects of two tyrosine kinase inhibitors, methyl 2,5-dihydroxycinnam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5ade0ff15e2711f19bd1d141bec967
https://doi.org/10.1016/0014-5793(93)81172-v
https://doi.org/10.1016/0014-5793(93)81172-v
Autor:
Paul Sargeant, Stewart O. Sage
Publikováno v:
Pharmacologytherapeutics. 64(3)
By virtue of their biological simplicity and widespread availability, platelets frequently have been used as a model system to study signal transduction. Such studies have revealed that changes in intracellular free calcium concentration are central
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24325788e581aafe0f79174c16889d94
https://pubmed.ncbi.nlm.nih.gov/7724656
https://pubmed.ncbi.nlm.nih.gov/7724656
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461363040
One of the key intracellular events in platelet activation is a rise in the cytosolic calcium concentration ([Ca2+]i). Ca2+ from two sources contributes to the signal: release from intracellular stores in the dense tubular system, and entry across th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::587106fb2ac2e6e9a52bb476b1f1d4cb
https://doi.org/10.1007/978-1-4615-2994-1_6
https://doi.org/10.1007/978-1-4615-2994-1_6
Publikováno v:
Cell calcium. 13(9)
We have previously reported that a component of ADP-evoked Ca 2+ entry in human platelets appears to be promoted following the release of Ca 2+ from intracellular stores. Other agonists may employ a similar mechanism. Here we have further investigate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0009a4c5770b7109b60ab99f82cf32c
https://pubmed.ncbi.nlm.nih.gov/1334809
https://pubmed.ncbi.nlm.nih.gov/1334809
Publikováno v:
Trends in Pharmacological Sciences. 15:282
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccdb927cd54f538aed7466a7fa7b6c51
https://doi.org/10.1016/0165-6147(94)90007-8
https://doi.org/10.1016/0165-6147(94)90007-8
Autor:
Shaun Treweek, Ewan Pearson, Natalie Smith, Ron Neville, Paul Sargeant, Brian Boswell, Frank Sullivan
Publikováno v:
University of St Andrews CRIS
University of Dundee
University of Dundee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::80daf5a5674b0f6023989174a14631d5
https://risweb.st-andrews.ac.uk/portal/en/researchoutput/desktop-software-to-identify-patients-eligible-for-recruitment-into-a-clinical-trial(49ab733c-1088-4c5d-b3ea-487cd7e54ef5).html
https://risweb.st-andrews.ac.uk/portal/en/researchoutput/desktop-software-to-identify-patients-eligible-for-recruitment-into-a-clinical-trial(49ab733c-1088-4c5d-b3ea-487cd7e54ef5).html