Zobrazeno 1 - 10
of 196
pro vyhledávání: '"Paul Santerre"'
Publikováno v:
PLoS ONE, Vol 19, Iss 1, p e0280101 (2024)
Senescence, particularly in the nucleus pulposus (NP) cells, has been implicated in the pathogenesis of disc degeneration, however, the mechanism(s) of annulus fibrosus (AF) cell senescence is still not well understood. Both TNFα and H2O2, have been
Externí odkaz:
https://doaj.org/article/8879072453d04cbaa260894da3de6ec7
Autor:
Neal I. Callaghan, Lauren J. Durland, Ronald G. Ireland, J. Paul Santerre, Craig A. Simmons, Locke Davenport Huyer
Publikováno v:
npj Regenerative Medicine, Vol 7, Iss 1, Pp 1-25 (2022)
Abstract The development of induced-pluripotent stem cell (iPSC)-derived cell types offers promise for basic science, drug testing, disease modeling, personalized medicine, and translatable cell therapies across many tissue types. However, in practic
Externí odkaz:
https://doaj.org/article/a9983e6cae9d46ba83d7a5e678f0381c
Autor:
Allen C.T. Teng, Marjan Tavassoli, Suja Shrestha, Ryan M. Marks, Meghan J. McFadden, Sonia L. Evagelou, Kyle Lindsay, Ava Vandenbelt, Wenping Li, Evgueni Ivakine, Ronald Cohn, J. Paul Santerre, Anthony O. Gramolini
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101933- (2023)
Summary: Here, we describe a protocol for purifying functional clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 (Cas9) from Staphylococcus aureus within 24 h and over 90% purity. SaCas9 purification begins with
Externí odkaz:
https://doaj.org/article/d1573157b4e54e4c84f54302f66cee69
Autor:
Jeremy A. Antonyshyn, Vienna Mazzoli, Meghan J. McFadden, Anthony O. Gramolini, Stefan O. P. Hofer, Craig A. Simmons, J. Paul Santerre
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Antonyshyn et al. establish a methodology for acquiring human adipose tissue-derived microvascular endothelial cells that can be readily applied in future vascular tissue engineering applications. The authors developed strategies to mitigate the non-
Externí odkaz:
https://doaj.org/article/1f3a0bde7e2840cba941ac6669c4daa6
Autor:
Kyle Battiston, Ian Parrag, Matthew Statham, Dimitra Louka, Hans Fischer, Gillian Mackey, Adam Daley, Fan Gu, Emily Baldwin, Bingqing Yang, Ben Muirhead, Emily Anne Hicks, Heather Sheardown, Leonid Kalachev, Christopher Crean, Jeffrey Edelman, J. Paul Santerre, Wendy Naimark
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Polymer-based systems are often considered a necessity for controlled drug delivery, but have well-known limitations. Here, the authors report on drug delivery implants formed solely from corticosteroid dimers, which demonstrate controlled release an
Externí odkaz:
https://doaj.org/article/bef9dd810b064602859deb552da70df7
Autor:
Jeremy A. Antonyshyn, Meghan J. McFadden, Anthony O. Gramolini, Stefan O.P. Hofer, J. Paul Santerre
Publikováno v:
Biomaterials and Biosystems, Vol 6, Iss , Pp 100049- (2022)
Adipose tissue is an abundant, accessible, and uniquely dispensable source of cells for vascular tissue engineering. Despite its intrinsic endothelial cells, considerable effort is directed at deriving endothelium from its resident stem and progenito
Externí odkaz:
https://doaj.org/article/b8b52c6428d748dba069a464883c719f
Publikováno v:
In Acta Biomaterialia February 2020 103:129-141
Autor:
Jeremy A. Antonyshyn, Meghan J. McFadden, Anthony O. Gramolini, Stefan O.P. Hofer, J. Paul Santerre
Publikováno v:
Stem Cells Translational Medicine, Vol 8, Iss 1, Pp 35-45 (2019)
Abstract Considerable effort has been directed toward deriving endothelial cells (ECs) from adipose‐derived mesenchymal stem cells (ASCs) since 2004, when it was first suggested that ECs and adipocytes share a common progenitor. While the capacity
Externí odkaz:
https://doaj.org/article/553cf1ba4bdb4976b6ebecad96d025f2
Publikováno v:
JOR Spine, Vol 3, Iss 2, Pp n/a-n/a (2020)
Abstract Current treatments for degenerative disc disease do not restore full biological functionality of the intervertebral disc (IVD). As a result, regenerative medicine approaches are being developed to generate a biological replacement that when
Externí odkaz:
https://doaj.org/article/28df127274004705bd26507480c9358a
Publikováno v:
Stem Cell Research, Vol 32, Iss , Pp 115-125 (2018)
Vascular smooth muscle cells (VSMCs) play essential roles in regulating blood vessel form and function and they are required for vascular tissue regeneration. Multipotent adipose derived stromal cells (ASCs) can be differentiated into VSMC-like cells
Externí odkaz:
https://doaj.org/article/e038d21048b44e9e91ca124bd6033b5a