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pro vyhledávání: '"Paul S.H. Wang"'
Autor:
Paul S.H. Wang, Michael O'donnell, Alistair Rutherford, John Pollard, Jean-Damien Charrier, Somhairle Maccormick, Ronald Knegtel, Philip Michael Reaper, David Kay, Joanne Pinder, Steven Durrant, Michael Mortimore, Stephen Clinton Young, Golec Julian M C
Publikováno v:
Journal of Medicinal Chemistry. 54:2320-2330
DNA-damaging agents are among the most frequently used anticancer drugs. However, they provide only modest benefit in most cancers. This may be attributed to a genome maintenance network, the DNA damage response (DDR), that recognizes and repairs dam
Autor:
Rongqian Wu, Michael Mortimore, Ping Wang, Golec Julian M C, Paul S.H. Wang, Stephane Maddens, Weifeng Dong, Michael Miksa, Peter A. Charlton, Peter Weber
Publikováno v:
Critical Care
Introduction Prevention of lymphocyte apoptosis by caspase inhibition has been proposed as a novel treatment approach in sepsis. However, it has not been clearly demonstrated that caspase inhibitors improve survival in sepsis models when dosed post-i