Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Paul S. Watson"'
Publikováno v:
Tetrahedron Letters. 50:298-301
Three subunits of the potent actin polymerization inhibitor Latrunculin B were synthesized and assembled using olefin–olefin ring closing metathesis chemistry to close the 14-membered macrocycle. Metathesis reactions of substrates with various remo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::883dd8aeb0660920378f84844c839956
https://doi.org/10.1016/j.tetlet.2008.10.144
https://doi.org/10.1016/j.tetlet.2008.10.144
Autor:
Andrew J. Tebben, Wenqing Yao, Prabhakar Reddy, Carl P. Decicco, John V. Duncia, Eric A. Wadman, Kimberly A. Solomon, Percy H. Carter, Patricia K. Welch, Paul Davies, Sandhya Mandlekar, George V. Delucca, Soo S. Ko, Paul S. Watson, Ilona Kariv, Chongsheng Shi, Gardner Daniel S, Dean A. Wacker, Swamy Yeleswaram, Dani M. Graden, Joseph B. Santella
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:576-585
Conformational analysis of trans-1,2-disubstituted cyclohexane CCR3 antagonist 2 revealed that the cyclohexane linker could be replaced by an acyclic syn-alpha-methyl-beta-hydroxypropyl linker. Synthesis and biological evaluation of mono- and disubst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d214eaeca57ea6e19611a6f286d27d9a
https://doi.org/10.1016/j.bmcl.2007.11.067
https://doi.org/10.1016/j.bmcl.2007.11.067
Autor:
Carl P. Decicco, Nicole Stowell, George L. Trainor, Robert C. Newton, Nao Asakawa, Steven M. Friedman, Kimberly A. Solomon, Kim Harrison, Patricia K. Welch, Bin Jiang, Paul S. Watson, Maryanne B. Covington, Soo S. Ko, Eric A. Wadman, Paul Davies
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:5695-5699
Linear unselective CCR3 antagonist leads with IC(50) values in the 200 nM range were converted into low nM binding compounds selective at CCR3 by moving the piperidine nitrogen substituent to the carbon at the 2-position of the ring. Substitution of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e00d69b7b8609837c7fb5ea4f7a5b499
https://doi.org/10.1016/j.bmcl.2006.08.012
https://doi.org/10.1016/j.bmcl.2006.08.012
Publikováno v:
Catheterization and Cardiovascular Interventions. 54:234-238
Paravalvular regurgitation associated with prothetic mitral valves is often a consequence of infectious endocarditis. The condition is usually treated with debridement and repeat surgical valve replacement. However, repeated operations are associated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89697ba26757d7ddda272f2a855bf7fc
https://doi.org/10.1002/ccd.1274
https://doi.org/10.1002/ccd.1274
Autor:
Gregory M. Scalia, Darryl J. Burstow, Con Aroney, Nicholas Bett, Paul S. Watson, Andrew J. Galbraith
Publikováno v:
Journal of the American College of Cardiology. 33:1549-1552
OBJECTIVES This study evaluated the effects of oral therapy with coenzyme Q on echocardiographic and hemodynamic indexes of left ventricular function and on quality of life in patients with chronic left ventricular dysfunction. BACKGROUND Coenzyme Q
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979516f6b5497a5f861468955d41a691
https://doi.org/10.1016/s0735-1097(99)00064-9
https://doi.org/10.1016/s0735-1097(99)00064-9
Autor:
David E. Gossman, Andrew C. Eisenhauer, Paul S. Watson, Thomas C. Piemonte, Peter Hadjipetrou, Christopher T. Pyne, Stephen V. Cox
Publikováno v:
The American Journal of Cardiology. 83:1018-1021
Acute infarct angioplasty on aortocoronary saphenous vein grafts (SVGs) poses significant challenges because of their degenerate morphology and presence of significant thrombus. Of 370 acute, primary, or rescue myocardial infarct angioplasties perfor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1904ab94ce2463fa4b1e0f0c2108b8e6
https://doi.org/10.1016/s0002-9149(99)00007-7
https://doi.org/10.1016/s0002-9149(99)00007-7
Autor:
Michael R. Wood, B. Wesley Trotter, Christopher J. Dinsmore, Jeffrey L. Katz, Timothy I. Richardson, David A. Evans, Paul S. Watson
Publikováno v:
Angewandte Chemie International Edition. 37:2704-2708
Controlling the elements of planar and axial chirality are the principal challenges in the synthesis of the aglycon of vancomycin. Vancomycin is the prototypical member of the glycopeptide family of antibiotics which are effective for the treatment o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0db903cb63546f2dd4b324bd29a37133
https://doi.org/10.1002/(sici)1521-3773(19981016)37:19<2704::aid-anie2704>3.0.co
https://doi.org/10.1002/(sici)1521-3773(19981016)37:19<2704::aid-anie2704>3.0.co
Autor:
Timothy I. Richardson, Michael R. Wood, Paul S. Watson, B. Wesley Trotter, David A. Evans, Jeffrey L. Katz, Christopher J. Dinsmore
Publikováno v:
Angewandte Chemie. 110:2868-2872
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adf87817875cffac419660fbfa59b65d
https://doi.org/10.1002/(sici)1521-3757(19981002)110:19<2868::aid-ange2868>3.0.co
https://doi.org/10.1002/(sici)1521-3757(19981002)110:19<2868::aid-ange2868>3.0.co
Autor:
Paul T. McEniery, Adam D. Cannon, Paul S. Watson, James D. Cameron, John H. N. Bett, Paul J. Garrahy, Constantine N. Aroney, Chandrashekhar K. Ponde, Mark Dooris
Publikováno v:
Catheterization and Cardiovascular Diagnosis. 43:168-173
The Cordis stent is a flexible, highly radioopaque intracoronary stent engineered from a single Tantalum filament folded into a sinusoidal helical coil. It is premounted on a semicompliant balloon expandable stent delivery system. From September 1995
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e501d8b2cad1974620e426314d88ed1
https://doi.org/10.1002/(sici)1097-0304(199802)43:2<168::aid-ccd12>3.0.co
https://doi.org/10.1002/(sici)1097-0304(199802)43:2<168::aid-ccd12>3.0.co
Publikováno v:
The Journal of Organic Chemistry. 71:8975-8977
A strategy for the enantioselective synthesis of trans-2,4-disubstituted piperidines is proposed and applied to the preparation of IS811, a potent CCR3 antagonist. The C2 stereocenter is derived from commercial (R)-epichlorohydrin, while the C4 stere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe2348681ffd3d90dc3590746181a1d
https://doi.org/10.1021/jo0616963
https://doi.org/10.1021/jo0616963