Zobrazeno 1 - 10
of 207
pro vyhledávání: '"Paul S. MacLean"'
Autor:
Elizabeth A. Wellberg, Karen A. Corleto, L. Allyson Checkley, Sonali Jindal, Ginger Johnson, Janine A. Higgins, Sarina Obeid, Steven M. Anderson, Ann D. Thor, Pepper J. Schedin, Paul S. MacLean, Erin D. Giles
Publikováno v:
Breast Cancer Research, Vol 24, Iss 1, Pp 1-13 (2022)
Abstract Background Obesity and adult weight gain are linked to increased breast cancer risk and poorer clinical outcomes in postmenopausal women, particularly for hormone-dependent tumors. Menopause is a time when significant weight gain occurs in m
Externí odkaz:
https://doaj.org/article/fe059f40f7664debab0869772fb8b494
Autor:
Rohan Varshney, Snehasis Das, G. Devon Trahan, Jacob W. Farriester, Gregory P. Mullen, Gertrude Kyere-Davies, David M. Presby, Julie A. Houck, Patricia G. Webb, Monika Dzieciatkowska, Kenneth L. Jones, Matthew S. Rodeheffer, Jacob E. Friedman, Paul S. MacLean, Michael C. Rudolph
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105750- (2023)
Summary: Establishing metabolic programming begins during fetal and postnatal development, and early-life lipid exposures play a critical role during neonatal adipogenesis. We define how neonatal consumption of a low omega-6 to −3 fatty acid ratio
Externí odkaz:
https://doaj.org/article/9bad93f7d4e444bcbb9d60d4a40fb54f
Autor:
Emily B. Hill, Iain R. Konigsberg, Diana Ir, Daniel N. Frank, Purevsuren Jambal, Elizabeth M. Litkowski, Ethan M. Lange, Leslie A. Lange, Danielle M. Ostendorf, Jared J. Scorsone, Liza Wayland, Kristen Bing, Paul S. MacLean, Edward L. Melanson, Daniel H. Bessesen, Victoria A. Catenacci, Maggie A. Stanislawski, Sarah J. Borengasser
Publikováno v:
Nutrients, Vol 15, Iss 16, p 3588 (2023)
Obesity has been linked to the gut microbiome, epigenome, and diet, yet these factors have not been studied together during obesity treatment. Our objective was to evaluate associations among gut microbiota (MB), DNA methylation (DNAme), and diet pri
Externí odkaz:
https://doaj.org/article/12eb4929d4de40b7a62c9ba0582b84c1
Autor:
Kathleen M. Gavin, Timothy M. Sullivan, Joanne K. Maltzahn, Matthew R. Jackman, Andrew E. Libby, Paul S. MacLean, Wendy M. Kohrt, Susan M. Majka, Dwight J. Klemm
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
A subpopulation of adipocytes in the major adipose depots of mice is produced from hematopoietic stem cells rather than mesenchymal progenitors that are the source of conventional white and brown/beige adipocytes. To analyze the impact of hematopoiet
Externí odkaz:
https://doaj.org/article/22273c03c9774595ab400ccd5f58462a
Autor:
Katharina Hopp, Victoria A. Catenacci, Nidhi Dwivedi, Timothy L. Kline, Wei Wang, Zhiying You, Dustin T. Nguyen, Kristen Bing, Bhavya Poudyal, Ginger C. Johnson, Matthew R. Jackman, Marsha Miller, Cortney N. Steele, Natalie J. Serkova, Paul S. MacLean, Raphael A. Nemenoff, Berenice Gitomer, Michel Chonchol, Kristen L. Nowak
Publikováno v:
iScience, Vol 25, Iss 1, Pp 103697- (2022)
Summary: Progression of autosomal dominant polycystic kidney disease (ADPKD) is modified by metabolic defects and obesity. Indeed, reduced food intake slows cyst growth in preclinical rodent studies. Here, we demonstrate the feasibility of daily calo
Externí odkaz:
https://doaj.org/article/01786711dc38457a958b92ee0aa73814
Autor:
Bridget E. Young, Gertrude Kyere-Davies, Jacob W. Farriester, Rohan Varshney, Paul S. MacLean, Nancy F. Krebs, Michael C. Rudolph
Publikováno v:
Nutrients, Vol 14, Iss 20, p 4238 (2022)
The prevalence of childhood obesity has increased nearly ten times over the last 40 years, influenced by early life nutrients that have persistent effects on life-long metabolism. During the first six months, infants undergo accelerated adipose accum
Externí odkaz:
https://doaj.org/article/2441807dbd064296b11459b21a81b003
Autor:
Ashley V. Ward, Shawna B. Matthews, Lynsey M. Fettig, Duncan Riley, Jessica Finlay-Schultz, Kiran V. Paul, Matthew Jackman, Peter Kabos, Paul S. MacLean, Carol A. Sartorius
Publikováno v:
Cancers, Vol 14, Iss 7, p 1776 (2022)
Metabolic reprogramming remains largely understudied in relation to hormones in estrogen receptor (ER) and progesterone receptor (PR) positive breast cancer. In this study, we investigated how estrogens, progestins, or the combination, impact metabol
Externí odkaz:
https://doaj.org/article/d469da9842184f6a9f9dae3331dc12e6
Autor:
Ana Andres-Hernando, Thomas J. Jensen, Masanari Kuwabara, David J. Orlicky, Christina Cicerchi, Nanxing Li, Carlos A. Roncal-Jimenez, Gabriela E. Garcia, Takuji Ishimoto, Paul S. Maclean, Petter Bjornstad, Laura Gabriela Sanchez-Lozada, Mehmet Kanbay, Takahiko Nakagawa, Richard J. Johnson, Miguel A. Lanaspa
Publikováno v:
JCI Insight, Vol 6, Iss 1 (2021)
Subjects with obesity frequently have elevated serum vasopressin levels, noted by measuring the stable analog, copeptin. Vasopressin acts primarily to reabsorb water via urinary concentration. However, fat is also a source of metabolic water, raising
Externí odkaz:
https://doaj.org/article/80f7afd7258d417f8fa2617a65aa510c
Autor:
Nathan P. De Jong, Michael C. Rudolph, Matthew R. Jackman, Rachel R. Sharp, Ken Jones, Julie Houck, Zhaoxing Pan, Jane E. B. Reusch, Paul S. MacLean, Daniel H. Bessesen, Audrey Bergouignan
Publikováno v:
Nutrients, Vol 14, Iss 3, p 454 (2022)
Breaking up sedentary behavior with short-frequent bouts of physical activity (PA) differentially influences metabolic health compared with the performance of a single-continuous bout of PA matched for total active time. However, the underlying mecha
Externí odkaz:
https://doaj.org/article/0463b8c177fb4042aebee807c8ffb377
Autor:
Erin D. Giles, Sonali Jindal, Elizabeth A. Wellberg, Troy Schedin, Steven M. Anderson, Ann D. Thor, Dean P. Edwards, Paul S. MacLean, Pepper Schedin
Publikováno v:
Breast Cancer Research, Vol 20, Iss 1, Pp 1-14 (2018)
Abstract Background Obesity and type II diabetes are linked to increased breast cancer risk in postmenopausal women. Patients treated with the antidiabetic drug metformin for diabetes or metabolic syndrome have reduced breast cancer risk, a greater p
Externí odkaz:
https://doaj.org/article/1bc7a8bf6ab4471982c750476155c88a