Výsledky vyhledávání - "Paul S. Lovett"

Suppression of TGA Mutations in the Bacillus subtilis spoIIR Gene by prfB Mutations

Autor: Paul S. Lovett, E J Rogers, Margaret L. Karow, Patrick J. Piggot

Publikováno v: Journal of Bacteriology. 180:4166-4170

An unexpectedly high proportion of TGA nonsense mutations was obtained in a collection of chemically induced mutations in the spoIIR locus of Bacillus subtilis . Of 11 different mutations obtained, TGA mutations were found in four codons, whereas onl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1599d741b5d3557a8a1f8af9d2caa5
https://doi.org/10.1128/jb.180.16.4166-4170.1998

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Translation attenuation regulation of chloramphenicol resistance in bacteria — a review

Autor: Paul S. Lovett

Publikováno v: Gene. 179:157-162

The chloramphenicol (Cm)-inducible cat and cmlA genes are regulated by translation attenuation, a regulatory device that modulates mRNA translation. In this form of gene regulation, translation of the CmR coding sequence is prevented by mRNA secondar

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https://doi.org/10.1016/s0378-1119(96)00420-9

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Peptide inhibitors of peptidyltransferase alter the conformation of domains IV and V of large subunit rRNA: a model for nascent peptide control of translation

Autor: Paul S. Lovett, Robert Harrod

Publikováno v: Proceedings of the National Academy of Sciences. 92:8650-8654

Peptides of 5 and 8 residues encoded by the leaders of attenuation regulated chloramphenicol-resistance genes inhibit the peptidyltransferase of microorganisms from the three kingdoms. Therefore, the ribosomal target for the peptides is likely to be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bb7d44c6926a4cf28c1ba2853e0d6a4
https://doi.org/10.1073/pnas.92.19.8650

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Evidence for a (Triosephosphate Isomerase-like) 'Catalytic Loop' near the Active Site of Glyoxalase I

Autor: Paul S. Lovett, Tianfen Lu, Yin Lan, Donald J. Creighton

Publikováno v: Journal of Biological Chemistry. 270:12957-12960

The conformational mobility of glyoxalase I (Glx I) during catalysis has been probed using stable analogs of the enediol intermediate that forms along the reaction pathway: GSC(O)N(OH)R, where GS = glutathionyl and R = CH3 (1), C6H5 (2), C6H4Cl (3),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bf9988fc7d67eea5ad19b7e87a19aa
https://doi.org/10.1074/jbc.270.22.12957

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Anti-peptidyl transferase leader peptides of attenuation-regulated chloramphenicol-resistance genes

Autor: Zhiping Gu, Robert Harrod, Elizabeth Rogers, Paul S. Lovett

Publikováno v: Proceedings of the National Academy of Sciences. 91:5612-5616

The chloramphenicol (Cm)-inducible cmlA gene of Tn1696 specifies nonenzymatic resistance to Cm and is regulated by attenuation. The first eight codons of the leader specify a peptide that inhibits peptidyl transferase in vitro. Functionally similar,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bac3b6ee3ee51ad2dd340cc5050f002
https://doi.org/10.1073/pnas.91.12.5612

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Analysis of the secondary structure that negatively regulates inducible cat translation by use of chemical probing and mutagenesis

Autor: Zhiping Gu, Robert Harrod, Paul S. Lovett

Publikováno v: Gene. 140:79-83

Induction of chloramphenicol (Cm) acetyltransferase-encoding genes (cat) by Cm has been proposed to result from the destabilization of a stem-loop that sequesters the ribosome-binding site for the cat coding sequence. Destabilization is caused by the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83eb92463d67111fbb9641897085e7da
https://doi.org/10.1016/0378-1119(94)90734-x

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Peptidyl transferase inhibition by the nascent leader peptide of an inducible cat gene

Autor: Zhiping Gu, E J Rogers, Paul S. Lovett

Publikováno v: Journal of Bacteriology. 175:5309-5313

The site of ribosome stalling in the leader of cat transcripts is critical to induction of downstream translation. Site-specific stalling requires translation of the first five leader codons and the presence of chloramphenicol, a sequence-independent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f39d23ea1071e33ac893b199b66b83d
https://doi.org/10.1128/jb.175.17.5309-5313.1993

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Ribosomal RNA and the Site Specificity of Chloramphenicol-Dependent Ribosome Stalling in cat Gene Leaders

Autor: Paul S. Lovett

Publikováno v: Annals of the New York Academy of Sciences. 646:31-34

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac7a667c0271a19d4f7664cf3996f13
https://doi.org/10.1111/j.1749-6632.1991.tb18560.x

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Constitutive expression of cat-86 associated with a change in the transcription start point

Autor: N P Ambulos, Un Jin Kim, Paul S. Lovett, E J Rogers

Publikováno v: Gene. 105:113-117

The translational attenuation regulatory model suggests a mechanism that can explain the induction of cat-86 by chloramphenicol (Cm). In this model, Cm serves to stall a ribosome at a specific site in a leader region of cat-86 transcripts. The stalle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::220d54d12c5051cb947b5834e0b589b4
https://doi.org/10.1016/0378-1119(91)90521-c

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