Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Paul S. Kayne"'
Autor:
John Dodd, Robert Jordan, Marie Makhlina, Keith Barnett, Ad Roffel, Carl Spana, Alison Obr, Priyanka Dhingra, Paul S. Kayne
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionPL8177 is a potent and selective agonist of the melanocortin 1 receptor (MC1R). PL8177 has shown efficacy in reversing intestinal inflammation in a cannulated rat ulcerative colitis model. To facilitate oral delivery, a novel, polymer-enc
Externí odkaz:
https://doaj.org/article/6822292f0ed94f7caf82349ccec80548
Autor:
Nataly Manjarrez-Orduño, Laurence C. Menard, Selena Kansal, Paul Fischer, Bijal Kakrecha, Can Jiang, Mark Cunningham, Danielle Greenawalt, Vishal Patel, Minghui Yang, Ryan Golhar, Julie A. Carman, Sergey Lezhnin, Hongyue Dai, Paul S. Kayne, Suzanne J. Suchard, Steven H. Bernstein, Steven G. Nadler
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Agents targeting the PD1–PDL1 axis have transformed cancer therapy. Factors that influence clinical response to PD1–PDL1 inhibitors include tumor mutational burden, immune infiltration of the tumor, and local PDL1 expression. To identify peripher
Externí odkaz:
https://doaj.org/article/9c0d0121b6ce4399a93cc25cb09ce921
Autor:
Paul S. Kayne, Michael Borys, Zheng Jian Li, Aiqing He, Yueming Qian, Matthew S. Rehmann, Nan-xin Qian
Publikováno v:
Biotechnology and Bioengineering. 115:1051-1061
Suspension cultivation is the preferred mode of operation for the large-scale production of many biologics. Chinese Hamster Ovary (CHO) cells are anchorage-dependent in origin, but they have been widely adapted to suspension culture. In suspension cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e1c425b6377fa21e81d04bbc27560c
https://doi.org/10.1002/bit.26520
https://doi.org/10.1002/bit.26520
Autor:
Paul S. Kayne, Robert Nadon
Publikováno v:
SLAS Discovery. 23:437-439
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65cdbe0e1f408bfacd1afac9691382e8
https://doi.org/10.1177/2472555218769904
https://doi.org/10.1177/2472555218769904
Autor:
Paul S. Kayne, Selena Kansal, Mark D. Cunningham, Can Jiang, Julie Carman, Minghui Yang, Danielle Greenawalt, Suzanne J. Suchard, Laurence Menard, Sergey Lezhnin, Steven H. Bernstein, Paul Fischer, Bijal Kakrecha, Nataly Manjarrez-Orduño, Steven G. Nadler, Vishal Patel, Hongyue Dai, Ryan Golhar
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 9 (2018)
Frontiers in Immunology, Vol 9 (2018)
Agents targeting the PD1-PDL1 axis have transformed cancer therapy. Factors that influence clinical response to PD1-PDL1 inhibitors include tumor mutational burden, immune infiltration of the tumor and local PDL1 expression. To identify peripheral co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1ef1f308377ee6fb0c6e0bf2e306ed
https://pubmed.ncbi.nlm.nih.gov/30123214
https://pubmed.ncbi.nlm.nih.gov/30123214
Autor:
Peter S. Gargalovic, Raffi Hagopian, Nam Che, Henna Cederberg, Johanna Kuusisto, Wen-Pin Yang, Mete Civelek, Todd G. Kirchgessner, Niyas K. Saleem, Markku Laakso, Aldons J. Lusis, Calvin Pan, Paul S. Kayne
Publikováno v:
Human Molecular Genetics. 22:3023-3037
The genetics of messenger RNA (mRNA) expression has been extensively studied in humans and other organisms, but little is known about genetic factors contributing to microRNA (miRNA) expression. We examined natural variation of miRNA expression in ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a094758ee6b87e032dfc65534e5a6bbc
https://doi.org/10.1093/hmg/ddt159
https://doi.org/10.1093/hmg/ddt159
Autor:
Wen Pin Yang, Paul S. Kayne, Charles R. Farber, Lawrence W. Castellani, Thomas A. Drake, Hyun Min Kang, Roumyana Yordanova, Michael G. Neubauer, Peter S. Gargalovic, Eleazar Eskin, Todd G. Kirchgessner, Luz D. Orozco, Anatole Ghazalpour, Amy Truong, Calvin Pan, Brian J. Bennett, Emrah Kostem, Aldons J. Lusis, Isaac M. Neuhaus, Nathan O. Siemers, Nicholas A. Furlotte, Bo Guan, Aiqing He
Publikováno v:
Genome Research. 20:281-290
Systems genetics relies on common genetic variants to elucidate biologic networks contributing to complex disease-related phenotypes. Mice are ideal model organisms for such approaches, but linkage analysis has been only modestly successful due to lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0351beb2ea9d7bfffc3954fc1fb1bbf5
https://doi.org/10.1101/gr.099234.109
https://doi.org/10.1101/gr.099234.109
Autor:
Qing Xiao, Jeffrey D. Hulmes, Joseph Y. Lu, Deidra Bethea, Stanley A. Hefta, Paul S. Kayne, Estelle M. Fach, Gregory J. Opiteck, Keith Ho
Publikováno v:
JALA: Journal of the Association for Laboratory Automation. 9:238-249
The discovery of new biomarkers will be an essential step to enhance our ability to better diagnose and treat human disease. The proteomics research community has recently increased its use of human blood (plasma/serum) as a sample source for these d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd6d74863ed28ec379267357b2dc27a6
https://doi.org/10.1016/j.jala.2004.03.003
https://doi.org/10.1016/j.jala.2004.03.003
Autor:
Sherry Lee, Zizhuo Xing, Paul S. Kayne, Nancy A. Mackin, Aiqing He, Nan-xin Qian, Zheng Jian Li, Yueming Qian, Qin He
Publikováno v:
Biotechnology journal. 9(11)
Shake flasks and bench-top bioreactors are widely used for cell culture process development, however, culture performances significantly differ between them. In order to apply the results received from small-scale cultures to production scale, it is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e680b6e69313c23d15508bcfe0d1add
https://pubmed.ncbi.nlm.nih.gov/25271019
https://pubmed.ncbi.nlm.nih.gov/25271019
Autor:
Todd G. Kirchgessner, Aldons J. Lusis, Luz D. Orozco, Nam Che, Raffi Hagopian, Calvin Pan, Paul S. Kayne, Diana M. Shih, Aiqing He, Wen Pin Yang, Anatole Ghazalpour, Brian J. Bennett
Publikováno v:
Molecular systems biology, vol 10, iss 5
Molecular Systems Biology
Molecular Systems Biology
We profiled and analyzed 283 metabolites representing eight major classes of molecules including Lipids, Carbohydrates, Amino Acids, Peptides, Xenobiotics, Vitamins and Cofactors, Energy Metabolism, and Nucleotides in mouse liver of 104 inbred and re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a65cf1893d14afd3ec324b956b48a9c
https://doi.org/10.15252/msb.20135004
https://doi.org/10.15252/msb.20135004