Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants

Autor: Angelo Agathanggelou, Victoria J. Weston, Tracey Perry, Nicholas J. Davies, Anna Skowronska, Daniel T. Payne, John S. Fossey, Ceri E. Oldreive, Wenbin Wei, Guy Pratt, Helen Parry, David Oscier, Steve J. Coles, Paul S. Hole, Richard L. Darley, Michael McMahon, John D. Hayes, Paul Moss, Grant S. Stewart, A. Malcolm R. Taylor, Tatjana Stankovic

Publikováno v: Haematologica, Vol 100, Iss 8 (2015)

Inactivation of the Ataxia Telangiectasia Mutated gene in chronic lymphocytic leukemia results in resistance to p53-dependent apoptosis and inferior responses to treatment with DNA damaging agents. Hence, p53-independent strategies are required to ta

Externí odkaz: https://doaj.org/article/043481b5ed054be7b760c0b02db05858

Supplemental Table S2 from Reactive Oxygen Species Drive Proliferation in Acute Myeloid Leukemia via the Glycolytic Regulator PFKFB3

Autor: Alex Tonks, Richard L. Darley, Nader Omidvar, Paul S. Hole, Sara Davies, Michelle Doyle, Marie Hodges, Namrata Rastogi, Goitseone L. Hopkins, Andrew J. Robinson

Statistically significant biochemicals profiled in this study.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80495d5647b401725b818c50971c9391
https://doi.org/10.1158/0008-5472.22426570.v1

Normal Hematopoietic Progenitor Subsets Have Distinct Reactive Oxygen Species, BCL2 and Cell-Cycle Profiles That Are Decoupled from Maturation in Acute Myeloid Leukemia.

Autor: Naeem Khan, Robert K Hills, Steve Knapper, Lora Steadman, Ushna Qureshi, Jerrald L Rector, Charlotte Bradbury, Nigel H Russell, Paresh Vyas, Alan K Burnett, David Grimwade, Paul S Hole, Sylvie D Freeman

Publikováno v: PLoS ONE, Vol 11, Iss 9, p e0163291 (2016)

In acute myeloid leukemia (AML) quiescence and low oxidative state, linked to BCL2 mitochondrial regulation, endow leukemic stem cells (LSC) with treatment-resistance. LSC in CD34+ and more mature CD34- AML have heterogeneous immunophenotypes overlap

Externí odkaz: https://doaj.org/article/08d6f25f419e49eab87480ffd98ec9d5

Interleukin-5 drives glycolysis and reactive oxygen species-dependent citric acid cycling by eosinophils

Autor: Catherine A. Thornton, Emma E. Vincent, Lindsey C. Felix, Paige Lacy, Nicholas Jones, Paul S. Hole, Louis M. Scott, James G. Cronin

Publikováno v: Jones, N, Vincent, E E, Felix, L C, Cronin, J G, Scott, L M, Hole, P S, Lacy, P & Thornton, C A 2019, ' Interleukin-5 drives glycolysis and reactive oxygen species-dependent citric acid cycling by eosinophils ', Allergy . https://doi.org/10.1111/all.14158

Introduction\ud \ud Eosinophils have been long implicated in antiparasite immunity and allergic diseases and, more recently, in regulating adipose tissue homeostasis. The metabolic processes that govern eosinophils, particularly upon activation, are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f858523ae76891dd565dc2bfd41d1a0d
https://research-information.bris.ac.uk/ws/files/220514251/Metabolic_reprogramming_in_human_eosinophils_Interleukin_5_drives_glycolysis_and_ROS_dependent_TCA_cycling_UNMARKED.pdf

Using Flow Cytometry to Detect and Measure Intracellular Thiol Redox Status in Viable T Cells from Heterogeneous Populations

Autor: Alex J, Wadley, Rhys G, Morgan, Richard L, Darley, Paul S, Hole, Steven J, Coles

Publikováno v: Methods in molecular biology (Clifton, N.J.). 1990

Increased production of reactive oxygen species (ROS) and deficiencies in cellular antioxidant defenses are the principal causes of cellular oxidative stress. ROS can react with a variety intracellular molecules, including redox active cysteine thiol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6ad7a7924c94b7517d2a83a444b9389d
https://pubmed.ncbi.nlm.nih.gov/31148062