Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Paul S. Frankel"'
Autor:
Amanda J. Hoonakker, Lisa M. McFadden, Paul S. Frankel, Christina M. Robson, Glen R. Hanson, Mario E. Alburges
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 346:173-181
Because of persistent social problems caused by methamphetamine (METH), new therapeutic strategies need to be developed. Thus, we investigated the response of central nervous system neurotensin (NT) systems to METH self-administration (SA) and their
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05677d308aa6277b6cdb7be3ddfef6d0
https://doi.org/10.1124/jpet.113.205310
https://doi.org/10.1124/jpet.113.205310
Publikováno v:
Annals of the New York Academy of Sciences. 1139:112-117
Neurotensin (NT) is a tridecapeptide associated with extrapyramidal and limbic pathways and is thought to inhibit dopamine (DA) functions in nigrostriatal, mesocortical, and mesolimbic systems. Because of these effects, NT has been referred to as an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bd678124882292723f4eb0344c3e2d
https://doi.org/10.1196/annals.1432.019
https://doi.org/10.1196/annals.1432.019
Publikováno v:
Neuropharmacology. 55:41-46
Interest in development of therapeutics targeting brain neuropeptide systems for treatment of cocaine addiction (e.g., κ opioid agonists) is based on animal data showing interactions between the neuropeptides, brain dopamine, and cocaine. In this au
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49db2e4d7cd752be9dec2531f09415bf
https://doi.org/10.1016/j.neuropharm.2008.04.019
https://doi.org/10.1016/j.neuropharm.2008.04.019
Publikováno v:
Neuropharmacology. 53:447-454
Animal data show that neuropeptide systems in the dopamine-rich brain areas of the striatum (caudate, putamen, and nucleus accumbens) are influenced by exposure to psychostimulants, suggesting that neuropeptides are involved in mediating aspects of b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15eaf2297a94b9a48b35e2e6108a5ebd
https://doi.org/10.1016/j.neuropharm.2007.06.009
https://doi.org/10.1016/j.neuropharm.2007.06.009
Autor:
Glen R. Hanson, Paul S. Frankel, Amanda J. Hoonakker, Kristen A. Keefe, Mario E. Alburges, Lloyd G. Bush
Publikováno v:
European Journal of Pharmacology. 522:47-54
Neurotensin is a neuropeptide associated with basal ganglia dopaminergic neurons. Because levels of neurotensin in striatal tissue are differentially affected by low or high doses of methamphetamine, we employed microdialysis to assess the dose-depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d39351d96c028ffe3d96af0347aea76c
https://doi.org/10.1016/j.ejphar.2005.08.036
https://doi.org/10.1016/j.ejphar.2005.08.036
Autor:
Paul S. Frankel, Kathryn A. Cunningham
Publikováno v:
Behavioral Neuroscience. 118:157-162
Agonists acting at the serotonin-1B receptor (5-HT1BR) and 5-HT2CR have been reported to potentiate and block, respectively, the discriminative stimulus effects of cocaine. The present investigation reassessed the antagonistic effects of the mixed 5-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd4866eb0276e1892c4fce6d6e0b36c5
https://doi.org/10.1037/0735-7044.118.1.157
https://doi.org/10.1037/0735-7044.118.1.157
Autor:
Kathryn A. Cunningham, Paul S. Frankel
Publikováno v:
Brain Research. 958:251-260
The hallucinogen d-lysergic acid diethylamide (d-LSD) evokes dramatic somatic and psychological effects. In order to analyze the neural activation induced by this unique psychoactive drug, we tested the hypothesis that expression of the immediate-ear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d817157b26cadd4817bf020c27d106
https://doi.org/10.1016/s0006-8993(02)03548-5
https://doi.org/10.1016/s0006-8993(02)03548-5
Publikováno v:
Brain Research. 838:222-226
The medial thalamus contains μ opioid receptors and sends a glutamatergic projection to the caudate putamen (CPu) in rat. Morphine-induced c-Fos expression in the CPu has been shown to be blocked by pretreatment with antagonists to N-methyl- d -aspa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792564eae3c23a800168e984f10503db
https://doi.org/10.1016/s0006-8993(99)01709-6
https://doi.org/10.1016/s0006-8993(99)01709-6
Autor:
Christina M. Robson, Paul S. Frankel, Amanda J. Hoonakker, Lisa M. McFadden, Mario E. Alburges, Glen R. Hanson
Methamphetamine (METH) abuse is personally and socially devastating. Although effects of METH on dopamine (DA) systems likely contribute to its highly addictive nature, no medications are approved to treat METH dependence. Thus, we and others have st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5441ebedaddebcec607512ca79e6fcc
https://europepmc.org/articles/PMC3275099/
https://europepmc.org/articles/PMC3275099/
Autor:
Jacob W. McDougall, Amanda J. Hoonakker, Lisa M. McFadden, Paul S. Frankel, Mario E. Alburges, Annette E. Fleckenstein, Glen R. Hanson
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 336(3)
Methamphetamine (METH) dependence causes alarming personal and social damage. Even though many of the problems associated with abuse of METH are related to its profound actions on dopamine (DA) basal ganglia systems, there currently are no approved m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85062074ed09aa9058b4289f843a57e0
https://pubmed.ncbi.nlm.nih.gov/21131268
https://pubmed.ncbi.nlm.nih.gov/21131268