Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Paul S Morgan"'
Autor:
Gary G Adams, Andrew Meal, Paul S Morgan, Qushmua E Alzahrani, Hanne Zobel, Ryan Lithgo, M Samil Kok, David T M Besong, Shahwar I Jiwani, Simon Ballance, Stephen E Harding, Naomi Chayen, Richard B Gillis
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0195010 (2018)
The structure and function of clinical dosage insulin and its analogues were assessed. This included 'native insulins' (human recombinant, bovine, porcine), 'fast-acting analogues' (aspart, glulisine, lispro) and 'slow-acting analogues' (glargine, de
Externí odkaz:
https://doaj.org/article/6f88f3f9db90488b922c9a3749e8fc14
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93814 (2014)
There is no well-established in vivo marker of nigral degeneration in Parkinson's disease (PD). An ideal imaging marker would directly mirror the loss of substantia nigra dopaminergic neurones, which is most prominent in sub-regions called nigrosomes
Externí odkaz:
https://doaj.org/article/e97e0facb7454e9397b9e53af09fa02a
Autor:
Alastair McCabe, Stewart Martin, Selene Rowe, Jagrit Shah, Paul S. Morgan, Damian Borys, Rafal Panek
Publikováno v:
European Radiology Experimental, Vol 8, Iss 1, Pp 1-14 (2024)
Abstract Background Tumour hypoxia is a recognised cause of radiotherapy treatment resistance in head and neck squamous cell carcinoma (HNSCC). Current positron emission tomography-based hypoxia imaging techniques are not routinely available in many
Externí odkaz:
https://doaj.org/article/4cdf90cad616462cb95ae643ce3f064e
Autor:
Cheryl V Rahman, Stuart J Smith, Paul S Morgan, Keith A Langmack, Phil A Clarke, Alison A Ritchie, Donald C Macarthur, Felicity R Rose, Kevin M Shakesheff, Richard G Grundy, Ruman Rahman
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77435 (2013)
INTRODUCTION:Polymer-based delivery systems offer innovative intra-cavity administration of drugs, with the potential to better target micro-deposits of cancer cells in brain parenchyma beyond the resected cavity. Here we evaluate clinical utility, t
Externí odkaz:
https://doaj.org/article/670d6a168407443193a9bee55d2a3c01
Autor:
Sarah Kohe, Christopher Bennett, Florence Burté, Magretta Adiamah, Heather Rose, Lara Worthington, Fatma Scerif, Lesley MacPherson, Simrandip Gill, Debbie Hicks, Edward C. Schwalbe, Stephen Crosier, Lisa Storer, Ambarasu Lourdusamy, Dipyan Mitra, Paul S. Morgan, Robert A. Dineen, Shivaram Avula, Barry Pizer, Martin Wilson, Nigel Davies, Daniel Tennant, Simon Bailey, Daniel Williamson, Theodoros N. Arvanitis, Richard G. Grundy, Steven C. Clifford, Andrew C. Peet
Publikováno v:
EBioMedicine, Vol 100, Iss , Pp 104958- (2024)
Summary: Background: The malignant childhood brain tumour, medulloblastoma, is classified clinically into molecular groups which guide therapy. DNA-methylation profiling is the current classification ‘gold-standard’, typically delivered 3–4 wee
Externí odkaz:
https://doaj.org/article/7ea57b301d434c53922cf4908ce48606
Autor:
Richard B. Gillis, Hodaya V. Solomon, Lata Govada, Neil J. Oldham, Vlad Dinu, Shahwar Imran Jiwani, Philemon Gyasi-Antwi, Frank Coffey, Andy Meal, Paul S. Morgan, Stephen E. Harding, John R. Helliwell, Naomi E. Chayen, Gary G. Adams
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract This study concerns glulisine, a rapid-acting insulin analogue that plays a fundamental role in diabetes management. We have applied a combination of methods namely X-ray crystallography, and biophysical characterisation to provide a detaile
Externí odkaz:
https://doaj.org/article/1baf07d48a3740889f7ac839d941f0d3
Autor:
Alice E. Thackray, Elanor C. Hinton, Turki M. Alanazi, Abdulrahman M. Dera, Kyoko Fujihara, Julian P. Hamilton‐Shield, James A. King, Fiona E. Lithander, Masashi Miyashita, Julie Thompson, Paul S. Morgan, Melanie J. Davies, David J. Stensel
Publikováno v:
Human Brain Mapping. 44:3815-3832
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9aa0faf312ace0f6dd928a2a0c249921
https://doi.org/10.1002/hbm.26314
https://doi.org/10.1002/hbm.26314
Autor:
Gary G. Adams, Qushmua Alzahrani, Shahwar I. Jiwani, Andrew Meal, Paul S. Morgan, Frank Coffey, Samil Kok, Arthur J. Rowe, Stephen E. Harding, Naomi Chayen, Richard B. Gillis
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Single, double and triple doses of the synthetic insulins glargine and degludec currently used in patient therapy are characterised using macromolecular hydrodynamic techniques (dynamic light scattering and analytical ultracentrifugation) in
Externí odkaz:
https://doaj.org/article/b78d16e655964b44a202114d783230a1
Publikováno v:
The British Journal of Radiology. 96
Objective: Oxygen-enhanced MRI (OE-MRI) or tissue oxygen-level dependent (TOLD) MRI is an imaging technique under investigation for its ability to quantify and map oxygen distributions within tumours. The aim of this study was to identify and charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b34ad43e1bc55ffe88277c7eef6c4a5
https://doi.org/10.1259/bjr.20220624
https://doi.org/10.1259/bjr.20220624
Autor:
Stephen J. Powell, Stephanie B. Withey, Yu Sun, James T. Grist, Jan Novak, Lesley MacPherson, Laurence Abernethy, Barry Pizer, Richard Grundy, Paul S. Morgan, Tim Jaspan, Simon Bailey, Dipayan Mitra, Dorothee P. Auer, Shivaram Avula, Theodoros N. Arvanitis, Andrew Peet
Publikováno v:
The British Journal of Radiology. 96
Objective: Investigate the performance of qualitative review (QR) for assessing dynamic susceptibility contrast (DSC-) MRI data quality in paediatric normal brain and develop an automated alternative to QR. Methods: 1027 signal–time courses were as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f3d2ca87bcdec3535fc32375c262bb4
https://doi.org/10.1259/bjr.20201465
https://doi.org/10.1259/bjr.20201465