Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Paul S Knoepfler"'
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185627 (2017)
The transcriptional functions of the class I histone deacetylases (HDACs) HDAC1 and HDAC2 are mainly viewed as both repressive and redundant based on murine knockout studies, but they may have additional independent roles and their physiological func
Externí odkaz:
https://doaj.org/article/76b1b4c7568b4b6a97753795f53c3580
Autor:
Olga A. Balashova, Alexios A. Panoutsopoulos, Olesya Visina, Jacob Selhub, Paul S. Knoepfler, Laura N. Borodinsky
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects consisting in the failure of the neural tube to form and close. The mechanisms underlying NTDs and their prevention by folate remain unclear. Here we
Externí odkaz:
https://doaj.org/article/f923a482aa8247899a9dcf1a160c9ade
Autor:
Bonnie L Barrilleaux, Dana Burow, Sarah H Lockwood, Abigail Yu, David J Segal, Paul S Knoepfler
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101151 (2014)
The transcription factor Miz-1 can either activate or repress gene expression in concert with binding partners including the Myc oncoprotein. The genomic binding of Miz-1 includes both core promoters and more distal sites, but the preferred DNA bindi
Externí odkaz:
https://doaj.org/article/3c90ecefd8224e8186338daae5bde6b2
Autor:
Verónica Martínez-Cerdeño, Jessica M Lemen, Vanessa Chan, Alice Wey, Wenchu Lin, Sharon R Dent, Paul S Knoepfler
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39456 (2012)
Here we examine the functions of the Myc cofactor and histone acetyltransferase, GCN5/KAT2A, in neural stem and precursor cells (NSC) using a conditional knockout approach driven by nestin-cre. Mice with GCN5-deficient NSC exhibit a 25% reduction in
Externí odkaz:
https://doaj.org/article/0331c03210244839b4fab5bd8aed4c35
Autor:
John K Meissen, Benjamin T K Yuen, Tobias Kind, John W Riggs, Dinesh K Barupal, Paul S Knoepfler, Oliver Fiehn
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46770 (2012)
Induced pluripotent stem cells are different from embryonic stem cells as shown by epigenetic and genomics analyses. Depending on cell types and culture conditions, such genetic alterations can lead to different metabolic phenotypes which may impact
Externí odkaz:
https://doaj.org/article/dfa564c47dfb414391e572ea7f5cf4a1
Autor:
Rebecca Cotterman, Paul S Knoepfler
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e5799 (2009)
myc genes are best known for causing tumors when overexpressed, but recent studies suggest endogenous myc regulates pluripotency and self-renewal of stem cells. For example, N-myc is associated with a number of tumors including neuroblastoma, but als
Externí odkaz:
https://doaj.org/article/3881e5c33eda49f282bf4047b14426bf
Autor:
Rachel H. Klein, Paul S. Knoepfler
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-8 (2023)
Abstract Histone variant H3.3 plays novel roles in development as compared to canonical H3 proteins and is the most commonly mutated histone protein of any kind in human disease. Here we discuss how gene targeting studies of the two H3.3-coding genes
Externí odkaz:
https://doaj.org/article/888b56556cad4593818e4d840c8bab5c
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-18 (2022)
Abstract Background The histone variant H3.3 K27M mutation is a defining characteristic of diffuse intrinsic pontine glioma (DIPG)/diffuse midline glioma (DMG). This histone mutation is responsible for major alterations to histone H3 post-translation
Externí odkaz:
https://doaj.org/article/6e3d279d2d3f4d91b8025625a68fbf5b
Autor:
Paul S. Knoepfler, Peggy J. Farnham, Alice Wey, Jessica M. Lemen, Sheryl R. Krig, Victor X. Jin, Rebecca Cotterman
Supplementary Figure 1 from N-Myc Regulates a Widespread Euchromatic Program in the Human Genome Partially Independent of Its Role as a Classical Transcription Factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe4001a23cc63b261fad329470ed2a5
https://doi.org/10.1158/0008-5472.22376952.v1
https://doi.org/10.1158/0008-5472.22376952.v1
Autor:
Paul S. Knoepfler, Peggy J. Farnham, Alice Wey, Jessica M. Lemen, Sheryl R. Krig, Victor X. Jin, Rebecca Cotterman
Myc proteins have long been modeled to operate strictly as classic gene-specific transcription factors; however, we find that N-Myc has a robust role in the human genome in regulating global cellular euchromatin, including that of intergenic regions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca4f8dce208c60d69cf9032c0cb5c5a7
https://doi.org/10.1158/0008-5472.c.6498381
https://doi.org/10.1158/0008-5472.c.6498381