Zobrazeno 1 - 10
of 257
pro vyhledávání: '"Paul S Gaynon"'
Autor:
Yin eLiu, Jingyan eTang, Peter eWakamatsu, Huiliang eXue, Jing eChen, Paul S Gaynon, Shuhong eShen, Weili eSun
Publikováno v:
Frontiers in Pediatrics, Vol 2 (2014)
Background: Molecular genetic alterations with prognostic significance have been described in childhood acute myeloid leukemia (AML). The aim of this study was to establish cost-effective techniques to detect mutations of FMS-like tyrosine kinase 3 (
Externí odkaz:
https://doaj.org/article/97e3a66bbc654a33a0d72b3de3d4a039
Autor:
Fatih M Uckun, Hong Ma, Rita Ishkhanian, Martha Arellano, Anoush Shahidzadeh, Amanda Termuhlen, Paul S Gaynon, Sanjive Qazi
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80732 (2013)
We examined the constitutive function of the Ikaros (IK) transcription factor in blast cells from pediatric B-precursor acute lymphoblastic leukemia (BPL) patients using multiple assay platforms and bioinformatics tools. We found no evidence of dimin
Externí odkaz:
https://doaj.org/article/637b1c2c2da34a5e8c5ea8b392ceca3b
Autor:
Sarah K. Tasian, Lewis B. Silverman, James A. Whitlock, Richard Sposto, Joseph P. Loftus, Eric S. Schafer, Kirk R. Schultz, Raymond J. Hutchinson, Paul S. Gaynon, Etan Orgel, Caroline M. Bateman, Todd M. Cooper, Theodore W. Laetsch, Maria Luisa Sulis, Yueh-Yun Chi, Jemily Malvar, Alan S. Wayne, Susan R. Rheingold
Publikováno v:
Haematologica, Vol 107, Iss 10 (2022)
Phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) signaling is commonly dysregulated in acute lymphoblastic leukemia (ALL). The TACL2014-001 phase I trial of the mTOR inhibitor temsirolimus in combination with cyclophosphamide
Externí odkaz:
https://doaj.org/article/8445bc9f98404419b1d22c8a88c190ec
Autor:
Alexandra E. Kovach, Elena Zerkalenkova, Ludmila Zemtsova, Aleksandra Borkovskaya, Marina Gaskova, Marat Kazanov, Alexander Popov, Liudmila Baidun, Michael Maschan, Alexey Maschan, Paul S. Gaynon, Deepa Bhojwani, Galina Novichkova, Yulia Olshanskaya, Gordana Raca
Publikováno v:
Cancer Genetics. :37-40
Pediatric acute myeloid leukemia (AML) is genetically heterogenous (Olsson et al., 2016). t(X;6)(p11;q23) is a rare but recurrent chromosomal translocation in infant AML thought to be associated with male sex and basophilic differentiation (Dastugue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956e41fd4fe42a6ab5e11239967ca34b
https://doi.org/10.1016/j.cancergen.2021.11.007
https://doi.org/10.1016/j.cancergen.2021.11.007
Autor:
Paul S. Gaynon
Publikováno v:
Haematologica, Vol 103, Iss 1 (2018)
Externí odkaz:
https://doaj.org/article/95310328a46349ebafc6752cfcc59d3e
Autor:
James A. Whitlock, Jemily Malvar, Luciano Dalla‐Pozza, John M. Goldberg, Lewis B. Silverman, David S. Ziegler, Andishe Attarbaschi, Patrick A. Brown, Rebecca A. Gardner, Paul S. Gaynon, Raymond Hutchinson, Van T. Huynh, Sima Jeha, Leigh Marcus, Yoav Messinger, Kirk R. Schultz, Jeannette Cassar, Franco Locatelli, C. Michel Zwaan, Brent L. Wood, Richard Sposto, Lia Gore
Publikováno v:
Pediatric Blood & Cancer, 69(11):e29901. Wiley-Liss Inc.
Children with relapse of T-cell acute lymphoblastic leukemia (T-ALL) or lymphoblastic lymphoma (T-LBL) have a dismal prognosis, largely due to difficulty attaining second remission. We hypothesized that adding etoposide and cyclophosphamide to the nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e3f4670cf701f4ccf8d3c500803e494
https://doi.org/10.1002/pbc.29901
https://doi.org/10.1002/pbc.29901
Autor:
Paul S. Gaynon
Publikováno v:
Haematologica, Vol 102, Iss 3 (2017)
Externí odkaz:
https://doaj.org/article/0645845caa03404894a386de44f07ed2
Autor:
Jessica A. Pollard, Victor M. Aquino, Leigh Marcus, Weili Sun, Blythe Thomson, Naomi J. Winick, Phoenix A. Ho, Anupam Verma, Julio C. Barredo, Rajen Mody, Michael J. Burke, Theodore W. Laetsch, John Goldberg, Rebecca Gardner, Wendy Tcheng, Cecilia Fu, Thomas Manley, Paul S. Gaynon, Richard Sposto, Julie Park, Yoav H. Messinger, Sima Jeha, Julia Glade Bender, Maria Luisa Sulis, Nobuko Hijiya
Publikováno v:
Pediatric Hematology and Oncology. 37:465-474
Background: Panobinostat demonstrates activity against pediatric cancers in vitro. A phase I trial in children with refractory hematologic malignancies was conducted. Study design: The trial evalua...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691e55398c8122c94fd4d7e88ce5ca1d
https://doi.org/10.1080/08880018.2020.1752869
https://doi.org/10.1080/08880018.2020.1752869
Autor:
Sebastian Armas, Carolina Huertas‐Ayala, Randall Y. Chan, Yueh‐Yun Chi, Winston W. Huh, Amanda Termuhlen, Paul S. Gaynon, Alexandra E. Kovach, Andrew Doan
Publikováno v:
Pediatr Blood Cancer
BACKGROUND: Adriamycin, bleomycin, vinblastine, dacarbazine (ABVD), the de-facto standard-of-care in adult-onset Hodgkin lymphoma (HL), has not been directly compared to doxorubicin, bleomycin, vincristine, etoposide, prednisone and cyclophosphamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060a906db61f965cf23db3ab382435a8
https://doi.org/10.1002/pbc.29601
https://doi.org/10.1002/pbc.29601
Autor:
Paul S. Gaynon, Chintan Parekh
Publikováno v:
Pediatric Blood & Cancer. 68
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a247fc13cb6a5074117cb93c5e2d8c91
https://doi.org/10.1002/pbc.29238
https://doi.org/10.1002/pbc.29238