Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Paul S Devenney"'
Autor:
Karamjit Singh Dolt, Melanie L Lawrence, Eve Miller-Hodges, Joan Slight, Anna Thornburn, Paul S Devenney, Peter Hohenstein
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e62054 (2013)
There is an increasing need for more efficient generation of transgenic constructs. Here we present a universal multi-site Gateway vector for use in recombineering reactions. Using transgenic mouse models, we show its use for the generation of BAC tr
Externí odkaz:
https://doaj.org/article/b314354c8ae344129f90f860e3a09364
Autor:
Zoe Crane-Smith, Jeffrey Schoenebeck, Katy A. Graham, Paul S. Devenney, Lorraine Rose, Mark Ditzell, Eve Anderson, Joseph I. Thomson, Natasha Klenin, Deborah M. Kurrasch, Laura A. Lettice, Robert E. Hill
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Enhancers that are conserved deep in evolutionary time regulate characteristics held in common across taxonomic classes. Here, deletion of the highly conserved Shh enhancer SBE2 (Shh brain enhancer 2) in mouse markedly reduced Shh expression within t
Externí odkaz:
https://doaj.org/article/cb6772378c2a4776b76a22338a57bbd1
Autor:
James H. Crichton, James M. Dunce, Orla M. Dunne, Lucy J. Salmon, Paul S. Devenney, Jennifer Lawson, Ian R. Adams, Owen R. Davies
Publikováno v:
Crichton, J, Dunce, J M, Dunne, O M, Salmon, L, Devenney, P S, Lawson, J, Adams, I R & Davies, O 2023, ' Structural maturation of SYCP1-mediated meiotic chromosome synapsis by SYCE3 ', Nature Structural & Molecular Biology . https://doi.org/10.1038/s41594-022-00909-1
In meiosis, a supramolecular protein structure, the synaptonemal complex (SC), assembles between homologous chromosomes to facilitate their recombination. Mammalian SC formation is thought to involve hierarchical zipper-like assembly of an SYCP1 prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::683a5976d6e39069e7495a4f2a6ccf09
https://doi.org/10.1038/s41594-022-00909-1
https://doi.org/10.1038/s41594-022-00909-1
Autor:
James H. Crichton, James M. Dunce, Orla M. Dunne, Lucy J. Salmon, Paul S. Devenney, Jennifer Lawson, Ian R. Adams, Owen R. Davies
In meiosis, a supramolecular protein structure, the synaptonemal complex (SC), assembles between homologous chromosomes to facilitate their recombination. Mammalian SC formation is thought to involve hierarchical zipper-like assembly of an SYCP1 prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c925610beb13feec98f7f44f1710c261
https://doi.org/10.1101/2022.03.06.483192
https://doi.org/10.1101/2022.03.06.483192
Autor:
Mark Ditzell, Lorraine Rose, Robert E. Hill, Eve Anderson, Natasha Klenin, Katy A. Graham, Deborah M. Kurrasch, Jeffrey J. Schoenebeck, Joseph I. Thomson, Paul S. Devenney, Laura A. Lettice, Zoe Crane-Smith
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology
Enhancers that are conserved deep in evolutionary time regulate characteristics held in common across taxonomic classes. Here, deletion of the highly conservedShhenhancer SBE2 (Shhbrain enhancer 2) in mouse markedly reducedShhexpression within the em
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d10087ee32257c4f8c65a83cab37c60
https://doi.org/10.3389/fcell.2021.595744
https://doi.org/10.3389/fcell.2021.595744
Autor:
Katy A. Graham, Eve Anderson, Robert E. Hill, Laura A. Lettice, Mark Ditzell, Lorraine Rose, Natasha Klenin, Deborah M. Kurrasch, Joseph I. Thomson, Jeffrey J. Schoenebeck, Zoe Crane-Smith, Paul S. Devenney
Enhancers that are conserved deep in evolutionary time regulate characteristics held in common across taxonomic classes. Here, deletion of the highly conservedShhenhancer SBE2 (Shhbrain enhancer 2) markedly reducedShhexpression within the embryonic b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1862358edb9d5b26e8902dc2fb954a57
https://doi.org/10.1101/794198
https://doi.org/10.1101/794198
Autor:
Eve Anderson, Wendy A. Bickmore, Laura A. Lettice, Robert E. Hill, Fiona Kilanowski, Lauren Kane, Paul S. Devenney, Iain Williamson
Topologically Associating Domains (TADs) have been proposed to both guide and constrain enhancer activity. Shh is located within a TAD known to contain all its enhancers. To investigate the importance of chromatin conformation and TAD integrity on de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a110ee29fbb030ba06de2507ad4a3a45
Autor:
Lauren Kane, Wendy A. Bickmore, Eve Anderson, Ilya M. Flyamer, Robert E. Hill, Fiona Kilanowski, Laura A. Lettice, Paul S. Devenney, Iain Williamson
Publikováno v:
Development
Williamson, I, Kane, L, Devenney, P S, Flyamer, I M, Anderson, E, Kilanowski, F, Hill, R E, Bickmore, W A & Lettice, L 2019, ' Developmentally regulated Shh expression is robust to TAD perturbations ', Development, vol. 146, dev179523 . https://doi.org/10.1242/dev.179523
Williamson, I, Kane, L, Devenney, P S, Flyamer, I M, Anderson, E, Kilanowski, F, Hill, R E, Bickmore, W A & Lettice, L 2019, ' Developmentally regulated Shh expression is robust to TAD perturbations ', Development, vol. 146, dev179523 . https://doi.org/10.1242/dev.179523
Topologically associating domains (TADs) have been proposed to both guide and constrain enhancer activity. Shh is located within a TAD known to contain all its enhancers. To investigate the importance of chromatin conformation and TAD integrity on de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a6b9c588f2606390914e66ae503fc3
https://doi.org/10.1242/dev.179523
https://doi.org/10.1242/dev.179523
Autor:
Graeme R. Grimes, Erika Abbondati, Martin A M Reijns, Ailsa Revuelta, Adeline Fluteau, Robert E. Hill, Žygimantė Tarnauskaitė, Paul S. Devenney, Rachel E. Rigby, Karen J. Mackenzie, Fiona Kilanowski, Andrew P. Jackson, Björn Rabe, Laura A. Lettice, Flora L. Dix, Kaalak Reddy, Paula Carroll
Publikováno v:
Mackenzie, K J, Carroll, P, Lettice, L, Tarnauskaite, Z, Reddy, K, Dix, F, Revuelta, A, Abbondati, E, Rigby, R E, Rabe, B, Kilanowski, F, Grimes, G R, Fluteau, A, Devenney, P S, Hill, R E, Reijns, M A M & Jackson, A P 2016, ' Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response ', EMBO Journal, vol. 35, no. 8, pp. 831-844 . https://doi.org/10.15252/embj.201593339
Aicardi–Goutières syndrome (AGS) provides a monogenic model of nucleic acid‐mediated inflammation relevant to the pathogenesis of systemic autoimmunity. Mutations that impair ribonuclease (RNase) H2 enzyme function are the most frequent cause of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fe67d0068015571f7a2094305894249
https://www.pure.ed.ac.uk/ws/files/24272499/Ribonclease_H2_mutationas_induce_a_cGAS_STING_dependent_innate_immune_response.pdf
https://www.pure.ed.ac.uk/ws/files/24272499/Ribonclease_H2_mutationas_induce_a_cGAS_STING_dependent_innate_immune_response.pdf
Autor:
Paul S. Devenney, Martin S. Taylor, Graeme R. Grimes, Andrea Leitch, Laura A. Lettice, Margaret A. Keighren, Kirstie A. Lawson, Robert E. Hill, Andrew P. Jackson, David Sexton, Shelagh Boyle, Björn Rabe, Pleasantine Mill, Julia R. Dorin, Rachel E. Rigby, Ian J. Holt, Martin A M Reijns, Fiona Kilanowski, Katy R. Astell
Publikováno v:
Cell
Reijns, M A M, Rabe, B, Rigby, R E, Mill, P, Astell, K R, Lettice, L A, Boyle, S, Leitch, A, Keighren, M, Kilanowski, F, Devenney, P S, Sexton, D, Grimes, G, Holt, I J, Hill, R E, Taylor, M S, Lawson, K A, Dorin, J R & Jackson, A P 2012, ' Enzymatic removal of ribonucleotides from DNA is essential for Mammalian genome integrity and development ', Cell, vol. 149, no. 5, pp. 1008-22 . https://doi.org/10.1016/j.cell.2012.04.011
Reijns, M A M, Rabe, B, Rigby, R E, Mill, P, Astell, K R, Lettice, L A, Boyle, S, Leitch, A, Keighren, M, Kilanowski, F, Devenney, P S, Sexton, D, Grimes, G, Holt, I J, Hill, R E, Taylor, M S, Lawson, K A, Dorin, J R & Jackson, A P 2012, ' Enzymatic removal of ribonucleotides from DNA is essential for Mammalian genome integrity and development ', Cell, vol. 149, no. 5, pp. 1008-22 . https://doi.org/10.1016/j.cell.2012.04.011
Summary The presence of ribonucleotides in genomic DNA is undesirable given their increased susceptibility to hydrolysis. Ribonuclease (RNase) H enzymes that recognize and process such embedded ribonucleotides are present in all domains of life. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::270ae408d9c75c4bebe64a9fc095bac9