Zobrazeno 1 - 10
of 209
pro vyhledávání: '"Paul S Brookes"'
Autor:
Tumininu S Faniyan, Xinyi Zhang, Donald A Morgan, Jorge Robles, Siresha Bathina, Paul S Brookes, Kamal Rahmouni, Rachel J Perry, Kavaljit H Chhabra
Publikováno v:
eLife, Vol 12 (2024)
The kidneys facilitate energy conservation through reabsorption of nutrients including glucose. Almost all the filtered blood glucose is reabsorbed by the kidneys. Loss of glucose in urine (glycosuria) is offset by an increase in endogenous glucose p
Externí odkaz:
https://doaj.org/article/2e669bfd729a4fe8806b8a45fdb3a01b
Autor:
Chaitanya A Kulkarni, Sergiy M Nadtochiy, Leslie Kennedy, Jimmy Zhang, Sophea Chhim, Hanan Alwaseem, Elizabeth Murphy, Dragony Fu, Paul S Brookes
Publikováno v:
eLife, Vol 9 (2020)
Alkb homolog 7 (ALKBH7) is a mitochondrial α-ketoglutarate dioxygenase required for DNA alkylation-induced necrosis, but its function and substrates remain unclear. Herein, we show ALKBH7 regulates dialdehyde metabolism, which impacts the cardiac re
Externí odkaz:
https://doaj.org/article/0dc515db99d74ef0bd80e3abdb1bbe69
Autor:
Laura C Shum, Noelle S White, Sergiy M Nadtochiy, Karen L de Mesy Bentley, Paul S Brookes, Jennifer H Jonason, Roman A Eliseev
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155709 (2016)
Pathogenic factors associated with aging, such as oxidative stress and hormone depletion converge on mitochondria and impair their function via opening of the mitochondrial permeability transition pore (MPTP). The MPTP is a large non-selective pore r
Externí odkaz:
https://doaj.org/article/8cf59e506817440ebb6201ddb3ce1570
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159989 (2016)
The mitochondrial unfolded protein response (UPRmt) is a surveillance pathway that defends proteostasis in the "powerhouse" of the cell. Activation of the UPRmt protects against stresses imposed by reactive oxygen species, respiratory chain deficits,
Externí odkaz:
https://doaj.org/article/7cede9758b72435a8c70d003625a704e
Autor:
Andrew P Wojtovich, Teresa A Sherman, Sergiy M Nadtochiy, William R Urciuoli, Paul S Brookes, Keith Nehrke
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28287 (2011)
Mitochondrial potassium channels are important mediators of cell protection against stress. The mitochondrial large-conductance "big" K(+) channel (mBK) mediates the evolutionarily-conserved process of anesthetic preconditioning (APC), wherein exposu
Externí odkaz:
https://doaj.org/article/df446d12a17047628ab10422eff63521
Autor:
Jolanta Skalska, Paul S Brookes, Sergiy M Nadtochiy, Shannon P Hilchey, Craig T Jordan, Monica L Guzman, Sanjay B Maggirwar, Margaret M Briehl, Steven H Bernstein
Publikováno v:
PLoS ONE, Vol 4, Iss 12, p e8115 (2009)
There has been much interest in targeting intracellular redox pathways as a therapeutic approach for cancer. Given recent data to suggest that the redox status of extracellular protein thiol groups (i.e. exofacial thiols) effects cell behavior, we hy
Externí odkaz:
https://doaj.org/article/b1a7001c5f124595b9ee8e68e7704479
Autor:
Rubens Sautchuk, Chen Yu, Matthew McArthur, Christine Massie, Paul S. Brookes, George A. Porter, Hani Awad, Roman A. Eliseev
Publikováno v:
Journal of Bone and Mineral Research. 38:522-540
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f28339a8242c9ce8a13adcd3fddb8c1a
https://doi.org/10.1002/jbmr.4787
https://doi.org/10.1002/jbmr.4787
Autor:
Ethan David Cohen, Min Yee, George A. Porter Jr., Erin Ritzer, Andrew N. McDavid, Paul S. Brookes, Gloria S. Pryhuber, Michael A. O’Reilly
Publikováno v:
JCI Insight, Vol 6, Iss 5 (2021)
Preterm birth increases the risk for pulmonary hypertension and heart failure in adulthood. Oxygen therapy can damage the immature cardiopulmonary system and may be partially responsible for the cardiovascular disease in adults born preterm. We previ
Externí odkaz:
https://doaj.org/article/52549453edfd42f29d70d399ca47d15f
Publikováno v:
Journal of Molecular and Cellular Cardiology. 174:101-114
Tissue ischemia results in intracellular pH (pHIN) acidification, and while accumulation of metabolites such as lactate is a known driver of acidic pHIN, less is known about how acidic pHIN regulates metabolism. Furthermore, acidic extracellular (pHE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d442ee7a304cd1945940ef2f4df9da
https://doi.org/10.1016/j.yjmcc.2022.11.008
https://doi.org/10.1016/j.yjmcc.2022.11.008
Publikováno v:
Redox Biology, Vol 37, Iss , Pp 101733- (2020)
Generation of mitochondrial reactive oxygen species (ROS) is an important process in triggering cellular necrosis and tissue infarction during ischemia-reperfusion (IR) injury. Ischemia results in accumulation of the metabolite succinate. Rapid oxida
Externí odkaz:
https://doaj.org/article/6df572c42a034fb3a50377e0f68f0b66