Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Paul S, Hole"'
Publikováno v:
MethodsX, Vol 5, Iss , Pp 1473-1483 (2018)
Flow cytometric methods for detecting and quantifying reduced intracellular thiol content using fluorescein-5-maleimide (F5M) in viable eukaryotic cells date back to 1983 (Durand and Olive [1]). There has been little development in these methodologie
Externí odkaz:
https://doaj.org/article/705c6ca9808142cca36f0c7c6650d22f
Autor:
Alex Tonks, Richard L. Darley, Nader Omidvar, Paul S. Hole, Sara Davies, Michelle Doyle, Marie Hodges, Namrata Rastogi, Goitseone L. Hopkins, Andrew J. Robinson
Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with a poor clinical outcome. Previously, we showed that overproduction of reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60% of patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a92f27d68149ad8b079b0b7d7f73f2
https://doi.org/10.1158/0008-5472.c.6512380.v1
https://doi.org/10.1158/0008-5472.c.6512380.v1
Autor:
Alex Tonks, Richard L. Darley, Nader Omidvar, Paul S. Hole, Sara Davies, Michelle Doyle, Marie Hodges, Namrata Rastogi, Goitseone L. Hopkins, Andrew J. Robinson
Statistically significant biochemicals profiled in this study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80495d5647b401725b818c50971c9391
https://doi.org/10.1158/0008-5472.22426570.v1
https://doi.org/10.1158/0008-5472.22426570.v1
Autor:
Alex Tonks, Richard L. Darley, Nader Omidvar, Paul S. Hole, Sara Davies, Michelle Doyle, Marie Hodges, Namrata Rastogi, Goitseone L. Hopkins, Andrew J. Robinson
This file contains Supplemental Methods, Supplemental Table S1 showing Comparison of gene changes in human hematopoietic cord blood (CD34+) mixed progenitor cells transduced with N-RASG12D or control (expressing GFP alone); Supplemental Fig. S1. Infe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370d74d9f388257ab958ae36c96f1670
https://doi.org/10.1158/0008-5472.22426573.v1
https://doi.org/10.1158/0008-5472.22426573.v1
Autor:
Naeem Khan, Robert K Hills, Steve Knapper, Lora Steadman, Ushna Qureshi, Jerrald L Rector, Charlotte Bradbury, Nigel H Russell, Paresh Vyas, Alan K Burnett, David Grimwade, Paul S Hole, Sylvie D Freeman
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163291 (2016)
In acute myeloid leukemia (AML) quiescence and low oxidative state, linked to BCL2 mitochondrial regulation, endow leukemic stem cells (LSC) with treatment-resistance. LSC in CD34+ and more mature CD34- AML have heterogeneous immunophenotypes overlap
Externí odkaz:
https://doaj.org/article/08d6f25f419e49eab87480ffd98ec9d5
Autor:
Namrata Rastogi, Goitseone Lucy Hopkins, Michelle Doyle, Andrew Robinson, Richard Lawrence Darley, Sara Davies, Nader Omidvar, Marie Hodges, Alex Tonks, Paul S. Hole
Publikováno v:
Cancer Res
Acute myeloid leukemia (AML) is a heterogeneous clonal disorder with a poor clinical outcome. Previously, we showed that overproduction of reactive oxygen species (ROS), arising from constitutive activation of NOX2 oxidase, occurs in >60% of patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d111634c9a80ba9eb205e17510dfd2f0
https://doi.org/10.1158/0008-5472.can-19-1920
https://doi.org/10.1158/0008-5472.can-19-1920
Autor:
Angelo Agathanggelou, Victoria J. Weston, Tracey Perry, Nicholas J. Davies, Anna Skowronska, Daniel T. Payne, John S. Fossey, Ceri E. Oldreive, Wenbin Wei, Guy Pratt, Helen Parry, David Oscier, Steve J. Coles, Paul S. Hole, Richard L. Darley, Michael McMahon, John D. Hayes, Paul Moss, Grant S. Stewart, A. Malcolm R. Taylor, Tatjana Stankovic
Publikováno v:
Haematologica, Vol 100, Iss 8 (2015)
Inactivation of the Ataxia Telangiectasia Mutated gene in chronic lymphocytic leukemia results in resistance to p53-dependent apoptosis and inferior responses to treatment with DNA damaging agents. Hence, p53-independent strategies are required to ta
Externí odkaz:
https://doaj.org/article/043481b5ed054be7b760c0b02db05858
Autor:
Catherine A. Thornton, Emma E. Vincent, Lindsey C. Felix, Paige Lacy, Nicholas Jones, Paul S. Hole, Louis M. Scott, James G. Cronin
Publikováno v:
Jones, N, Vincent, E E, Felix, L C, Cronin, J G, Scott, L M, Hole, P S, Lacy, P & Thornton, C A 2019, ' Interleukin-5 drives glycolysis and reactive oxygen species-dependent citric acid cycling by eosinophils ', Allergy . https://doi.org/10.1111/all.14158
Introduction\ud \ud Eosinophils have been long implicated in antiparasite immunity and allergic diseases and, more recently, in regulating adipose tissue homeostasis. The metabolic processes that govern eosinophils, particularly upon activation, are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f858523ae76891dd565dc2bfd41d1a0d
https://research-information.bris.ac.uk/ws/files/220514251/Metabolic_reprogramming_in_human_eosinophils_Interleukin_5_drives_glycolysis_and_ROS_dependent_TCA_cycling_UNMARKED.pdf
https://research-information.bris.ac.uk/ws/files/220514251/Metabolic_reprogramming_in_human_eosinophils_Interleukin_5_drives_glycolysis_and_ROS_dependent_TCA_cycling_UNMARKED.pdf
Autor:
Andrew J.K. Williamson, Chinmay Munje, Sarah Baker, Samuel J. Taylor, Marie Hodges, Steven Knapper, Michelle Doyle, Amanda F. Gilkes, Namrata Rastogi, Alex Tonks, Paul S. Hole, Andrew Pierce, Bader Alanazi, Richard Lawrence Darley, Anthony D. Whetton
Publikováno v:
Whetton, A 2019, ' Integrated nuclear proteomics and transcriptomics identifies S100A4 as a therapeutic target in acute myeloid leukemia ', Leukemia . https://doi.org/10.1038/s41375-019-0596-4
Leukemia
Leukemia
Inappropriate localization of proteins can interfere with normal cellular function and drive tumor development. To understand how this contributes to the development of acute myeloid leukemia (AML), we compared the nuclear proteome and transcriptome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00fe193e4d99aaf88f1b09fd83aab60c
https://research.manchester.ac.uk/en/publications/ab3f82f5-6f57-40ff-b2e5-5d860ac17574
https://research.manchester.ac.uk/en/publications/ab3f82f5-6f57-40ff-b2e5-5d860ac17574
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1990
Increased production of reactive oxygen species (ROS) and deficiencies in cellular antioxidant defenses are the principal causes of cellular oxidative stress. ROS can react with a variety intracellular molecules, including redox active cysteine thiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ad7a7924c94b7517d2a83a444b9389d
https://pubmed.ncbi.nlm.nih.gov/31148062
https://pubmed.ncbi.nlm.nih.gov/31148062