Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Paul Ratcliffe"'
Autor:
Kirstine Kløve-Mogensen, Rudi Steffensen, Hans Linde Nielsen, Tania Nicole Masmas, Andreas Glenthøj, Christina Friis Jensen, Thure Mors Haunstrup, Paul Ratcliffe, Petter Höglund, Henrik Hasle, Kaspar René Nielsen
Publikováno v:
Clinical Immunology Communications, Vol 3, Iss , Pp 31-36 (2023)
Autoimmune neutropenia (AIN) of early childhood is caused by autoantibodies against antigens on the neutrophil membrane. Human leukocyte antigens (HLA) have previously been associated with AIN. This study investigated HLA-DRB1 and HLA-DQB1 alleles in
Externí odkaz:
https://doaj.org/article/a1677bd5dce24be094371e3d2bfedc96
Autor:
Kirstine Kløve‐Mogensen, Rudi Steffensen, Tania Nicole Masmas, Andreas Glenthøj, Christina Friis Jensen, Thure Mors Haunstrup, Paul Ratcliffe, Petter Höglund, Henrik Hasle, Kaspar René Nielsen
Publikováno v:
Kløve-Mogensen, K, Steffensen, R, Masmas, T N, Glenthøj, A B, Jensen, C F, Haunstrup, T M, Ratcliffe, P, Höglund, P, Hasle, H & Nielsen, K R 2023, ' Genetic variations in low-to-medium-affinity Fcγ receptors and autoimmune neutropenia in early childhood in a Danish cohort ', International Journal of Immunogenetics, vol. 50, no. 2, pp. 65-74 . https://doi.org/10.1111/iji.12614
Kløve-Mogensen, K, Steffensen, R, Masmas, T N, Glenthøj, A, Jensen, C F, Haunstrup, T M, Ratcliffe, P, Höglund, P, Hasle, H & Nielsen, K R 2023, ' Genetic variations in low-to-medium-affinity Fcγ receptors and autoimmune neutropenia in early childhood in a Danish cohort ', International Journal of Immunogenetics, vol. 50, no. 2, pp. 65-74 . https://doi.org/10.1111/iji.12614
Kløve-Mogensen, K, Steffensen, R, Masmas, T N, Glenthøj, A, Jensen, C F, Haunstrup, T M, Ratcliffe, P, Höglund, P, Hasle, H & Nielsen, K R 2023, ' Genetic variations in low-to-medium-affinity Fcγ receptors and autoimmune neutropenia in early childhood in a Danish cohort ', International Journal of Immunogenetics, vol. 50, no. 2, pp. 65-74 . https://doi.org/10.1111/iji.12614
Autoimmune neutropenia (AIN) in early childhood is caused by autoantibodies directed against antigens on the neutrophil membrane and is a frequent cause of neutropenia in children. Association of AIN with Fcγ receptor (FCGR) 3B variants is well desc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32e29e62c42a84930211f07ffd4c7858
https://vbn.aau.dk/da/publications/f04a3150-e91c-4049-ba2e-86d2a76766f7
https://vbn.aau.dk/da/publications/f04a3150-e91c-4049-ba2e-86d2a76766f7
Autor:
Peter Bergman, Per‐Anders Broliden, Paul Ratcliffe, Magda Lourda, Brigitte Flesch, Petter Höglund, Jan Palmblad
Publikováno v:
American Journal of Hematology. 97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::783f107bdd2358a3a3e62e3e7e0cbb6b
https://doi.org/10.1002/ajh.26532
https://doi.org/10.1002/ajh.26532
Autor:
Kate McAdam, Cinzia Bordoni, Miller Duncan Charles, Daniel J. Brough, James H. Hunter, Pasquale A. Morese, Nikolay Sitnikov, Mélanie Uguen, Gemma Davison, J. Daniel Lopez-Fernandez, Paul Ratcliffe, Alexia Papaioannou, Michael J. Waring
Publikováno v:
The Medicinal Chemist's Guide to Solving ADMET Challenges ISBN: 9781788012270
Interaction with cardiac ion channels can potentially result in severe or even fatal cardiac side effects. The most prominent of cardiac channels, human ether-a-go-go-related gene (hERG), voltage-gated sodium channel 1.5 (NaV1.5) and voltage-gated ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b724a3741ae0b28930cbef06ccb7441
https://doi.org/10.1039/9781788016414-00403
https://doi.org/10.1039/9781788016414-00403
Autor:
Brent R. Whitehead, Michael M.-C. Lo, Amjad Ali, Min K. Park, Scott B. Hoyt, Yusheng Xiong, Jiaqiang Cai, Emma Carswell, Andrew Cooke, John MacLean, Paul Ratcliffe, John Robinson, D. Jonathan Bennett, Joseph A. Clemas, Tom Wisniewski, Mary Struthers, Doris Cully, Douglas J. MacNeil
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:143-146
This invention relates to triazolopyridyl compounds of the structural formula: [Formula should be inserted here] or their pharmaceutically acceptable salts, wherein the variable are defined herein. The inventive compounds selectively inhibit aldoster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a3f370cc26a7dc473d889e2fc7da4ea
https://doi.org/10.1016/j.bmcl.2016.12.003
https://doi.org/10.1016/j.bmcl.2016.12.003
Autor:
Behnaz Bayat, Núria Nogués, Leendert Porcelijn, Josina Kellershohn, Hans Kerchrom, Angelika Reil, Elly Huiskes, Paul Ratcliffe, Carme Canals, Brigitte K. Flesch, Petter Höglund, Marlies Schönbacher, Torsten J. Schulze, Peter Bugert
Publikováno v:
Transfus Med Hemother
Background: The human neutrophil antigen 2 (HNA-2), which is expressed on CD177, is undetectable in 3–5% of the normal population. Exposure of these HNA-2null individuals to HNA-2-positive cells can cause immunization and production of HNA-2 anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621b96de2711bfc2d2c8bb13497a67f2
https://pubmed.ncbi.nlm.nih.gov/33173457
https://pubmed.ncbi.nlm.nih.gov/33173457
Autor:
Jo Alen, Markus Schade, Markus Wagener, Frank Christian, Sonja Nordhoff, Beatrix Merla, Torsten R. Dunkern, Gregor Bahrenberg, Paul Ratcliffe
Publikováno v:
Journal of medicinal chemistry. 62(13)
Genome-wide-association studies in chronic low back pain patients identified sepiapterin reductase as a high interest target for developing new analgesics. Here we used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617ad842f88bc8ec26cb28fefdebfa95
https://pubmed.ncbi.nlm.nih.gov/31244106
https://pubmed.ncbi.nlm.nih.gov/31244106
Autor:
Klaus Linz, Olaf Will, André Welbers, Virginia Marossek, Rolf Terlinden, Klaus Hansen, Bert Nolte, Irena Loryan, Margareta Hammarlund-Udenaes, Paul Ratcliffe, Achim Kless, Anita Wegert, Derek Saunders, Edmund Hoppe, Felix Held
Drug induced phospholipidosis (PLD) may be observed in the preclinical phase of drug development and pose strategic questions. As lysosomes have a central role in pathogenesis of PLD, assessment of lysosomal concentrations is important for understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477e220a5faacb4b5061bcd395774bb2
https://publica.fraunhofer.de/handle/publica/253775
https://publica.fraunhofer.de/handle/publica/253775
Autor:
Robert A. Campbell, Angus John Morrison, Julia M. Adam, Daniel Ecker, Stuart Francis, James Baker, Anna-Marie Easson, Fiona Jeremiah, Ola Epemolu, Takao Kiyoi, Roberta Bursi, Duncan McArthur, Jurgen Schulz, Darren Edwards, Paul Passier, Maureen Deehan, Paul Westwood, Joanna Udo de Haes, Peter G. Schnabel, Jean E. Cottney, John K. Clark, Glenn Walker, Paul Harradine, Heinz Steinbrede, Paul Ratcliffe, Grant Wishart, Ruth Fields, Jack Pick, Louise Evans
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2541-2546
We report an expansion of the structure-activity relationship (SAR) of a novel series of indole-3-heterocyclic CB1 receptor agonists. Starting from the potent but poorly soluble lead, 1, a rational approach was taken in order to balance solubility, h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bac4fce3568bffcc8bec0c8ef27a0ea4
https://doi.org/10.1016/j.bmcl.2011.02.023
https://doi.org/10.1016/j.bmcl.2011.02.023
Publikováno v:
Anaerobe. 38
Eggerthella lenta is a Gram-positive anaerobic bacillus. Improved diagnostics and increased awareness of rare pathogens have revealed its potential to cause serious invasive infections. In this study, 18 clinical E. lenta isolates derived from positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b61482fb1a8c90c10747e8a461eb8928
https://pubmed.ncbi.nlm.nih.gov/26612006
https://pubmed.ncbi.nlm.nih.gov/26612006