Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Paul R. Wosniok"'
1
SAR Studies of the Leupyrrins: Design and Total Synthesis of Highly Potent Simplified Leupylogs
Autor: Bettina Hinkelmann, Christopher Knopf, Sandra Dreisigacker, Dirk Menche, Paul R. Wosniok, J. Manuel Orozco-Rodriguez, Peter P. Mueller, Mark Brönstrup
Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany)
Germany
Chemistry (Weinheim an Der Bergstrasse, Germany)
Leupyrrins are highly potent antifungal agents. A structure–activity‐relationship study of natural and synthetic derivatives is reported which reveals important insights into the biological relevance of several structural subunits leading to the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35086b93710d5f1f1e32777de047338a
https://pubmed.ncbi.nlm.nih.gov/33174290
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2
Total Synthesis of Leupyrrins A1and B1, Highly Potent Antifungal Agents from the MyxobacteriumSorangium cellulosum
Autor: Maoqun Tian, Tongtong Wang, Thomas Debnar, Sebastian Thiede, Daniel Herkommer, Michael Schrempp, Dirk Menche, Paul R. Wosniok
Publikováno v: Chemistry - A European Journal. 23:3300-3320
Full details on the design, elaboration, and application of efficient strategies for the high-yielding total syntheses of leupyrrins A1 and B1 , unique antifungal agents from the myxobacterium Sorangium cellulosum, are reported. A sequential zirconoc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0be286e008d18e8a3970961d3c9184f5
https://doi.org/10.1002/chem.201604445
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3
Total Synthesis of Leupyrrin B1: A Potent Inhibitor of Human Leukocyte Elastase
Autor: Michael Gütschow, Dirk Menche, Daniel Herkommer, Anna-Christina Schulz-Fincke, Sebastian Thiede, Paul R. Wosniok
Publikováno v: Organic Letters. 18:3964-3967
The total synthesis of leupyrrin B1 was accomplished by an expedient strategy that involves an optimized HATU-mediated amide coupling protocol of elaborate substrates. The generally useful procedure was also successfully applied in an improved total
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d5a1dd8451203c0c7cc24eb15285595
https://doi.org/10.1021/acs.orglett.6b01724
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5
ChemInform Abstract: Stereochemical Determination of the Leupyrrins and Total Synthesis of Leupyrrin A1
Autor: Sebastian Thiede, Sandra Dreisigacker, Herbert Irschik, Maoqun Tian, Dirk Menche, Thomas Debnar, Daniel Herkommer, Paul R. Wosniok
Publikováno v: ChemInform. 46
The relative and absolute configurations of potent antifungal agents leupyrrin A1 (I) and B1 (II) are determined by a combination of high field NMR studies, molecular modeling, and chemical derivatization.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c158ff51f5448db56094a79434f353d
https://doi.org/10.1002/chin.201535239
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6
Stereochemical determination of the leupyrrins and total synthesis of leupyrrin A1
Autor: Herbert Irschik, Maoqun Tian, Sebastian Thiede, Sandra Dreisigacker, Paul R. Wosniok, Daniel Herkommer, Dirk Menche, Thomas Debnar
Publikováno v: Journal of the American Chemical Society. 137(12)
The stereochemical determination of the potent antifungal agents leupyrrin A1 and B1 and the total synthesis of leupyrrin A1 are reported. The relative and absolute configuration was determined by a combination of high field NMR studies, molecular mo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af5974bdd264802ddd7eb54b7b837e9
https://pubmed.ncbi.nlm.nih.gov/25769018
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