Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Paul R. Werkhoven"'
Autor:
Helmus van de Langemheen, Paul R. Werkhoven, Steffen van der Wal, Rob M. J. Liskamp, John A. W. Kruijtzer
Publikováno v:
Journal of Peptide Science. 20:235-239
Synthetic mimics of discontinuous epitopes may have a wide range of potential applications, including synthetic vaccines and inhibition of protein-protein interactions. However, synthetic access to these relatively complex peptide molecular construct
Autor:
Serena Tschan, Anika M. Jonker, Rob M. J. Liskamp, Makoah N. Aminake, Fanny Joanny, Paul R. Werkhoven, Benjamin Mordmüller, Lena Wagner, Gabriele Pradel, Arwin J. Brouwer, Sarah Knittel
Publikováno v:
Antimicrobial Agents and Chemotherapy. 57:3576-3584
Despite declining numbers of cases and deaths, malaria remains a major public health problem in many parts of the world. Today, case management relies heavily on a single class of antimalarial compounds: artemisinins. Hence, development of resistance
Autor:
Paul R. Werkhoven, H. C. Quarles van Ufford, T. J. Meuleman, Rob M. J. Liskamp, John A. W. Kruijtzer, M. Elwakiel
Publikováno v:
Organic & Biomolecular Chemistry, 14(2), 701. Royal Society of Chemistry
Mimics of discontinuous epitopes of for example bacterial or viral proteins may have considerable potential for the development of synthetic vaccines, especially if conserved epitopes can be mimicked. However, due to the structural complexity and siz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f6cf75a651385b84f3737dbddcc6ec9
https://dspace.library.uu.nl/handle/1874/328183
https://dspace.library.uu.nl/handle/1874/328183
Autor:
Paul R, Werkhoven, Helmus, van de Langemheen, Steffen, van der Wal, John A W, Kruijtzer, Rob M J, Liskamp
Publikováno v:
Journal of peptide science : an official publication of the European Peptide Society. 20(4)
Synthetic mimics of discontinuous epitopes may have a wide range of potential applications, including synthetic vaccines and inhibition of protein-protein interactions. However, synthetic access to these relatively complex peptide molecular construct
Autor:
Paul R. Werkhoven, Rob M. J. Liskamp
Publikováno v:
Drug Discovery ISBN: 9781849736015
Nowadays, the designation “peptide epitope” relates to peptide segments, which are essential in protein–protein interactions. The ability to adequately mimic these epitopes will open up an abundance of important applications, varying from inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e31c7aea6552fcf894ffd63ffd04aed
https://doi.org/10.1039/9781849737159-00263
https://doi.org/10.1039/9781849737159-00263
Autor:
Nan Li, Paul R. Werkhoven, Ethan Kuo, Arwin J. Brouwer, Bogdan I. Florea, Johan Kemmink, Anika M. Jonker, Rob M. J. Liskamp, Michael Groll, Nerea Gallastegui, Herman S. Overkleeft
Publikováno v:
Journal of medicinal chemistry. 55(24)
A new class of potent proteasome inhibitors is described, of which the members contain an amino acid inspired sulfonyl fluoride as the electrophilic trap. In total, 24 peptido sulfonyl fluoride inhibitors have been designed and synthesized, which wer