Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Paul R. Tomlinson"'
Publikováno v:
AIRWAY WALL REMODELLING in ASTHMA ISBN: 9781003068792
AIRWAY WALL REMODELLING in ASTHMA
AIRWAY WALL REMODELLING in ASTHMA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::558fa92e9e5529bad8666095e1aab931
https://doi.org/10.1201/9781003068792-11
https://doi.org/10.1201/9781003068792-11
Autor:
Michal Rolinski, Michele T.M. Hu, Paul R. Tomlinson, Yoav Ben-Shlomo, Kannan Nithi, Konrad Szewczyk-Krolikowski, Kevin Talbot
Publikováno v:
Journal of Neurology, Neurosurgery, and Psychiatry
BACKGROUND: Concomitant REM sleep behaviour disorder (RBD) is commonly observed in patients with Parkinson's disease (PD). Although the brainstem structures responsible for the symptoms of RBD correspond to the premotor stages of PD, the association
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76cd5e66a20f0f4008759fabfcba09b
https://doi.org/10.1136/jnnp-2013-306104
https://doi.org/10.1136/jnnp-2013-306104
Autor:
Kannan Nithi, Michal Rolinski, Yoav Ben-Shlomo, Paul R. Tomlinson, Margaret T May, Fahd Baig, Michael T. Lawton, Michele T.M. Hu, Konrad Szewczyk-Krolikowski, Claudio Ruffmann
Background Conventional “top-down” classification approaches depend on a-priori assumptions about disease phenotype. “Bottom-up” data-driven statistical approaches in well-characterised, incident cohorts are relatively novel and may have spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fee8a370c8e1b69357ee6f6660f9f8e
https://ora.ox.ac.uk/objects/uuid:d8b051d3-a05c-48c2-a311-424ce90749b5
https://ora.ox.ac.uk/objects/uuid:d8b051d3-a05c-48c2-a311-424ce90749b5
Autor:
Yoav Ben-Shlomo, Konrad Szewczyk-Krolikowski, Michele T.M. Hu, Richard Wade-Martins, Kannan Nithi, Paul R. Tomlinson, Kevin Talbot
Publikováno v:
Parkinsonism and Related Disorders. 20(1)
Background: Identifying factors influencing phenotypic heterogeneity in Parkinson's Disease is crucial for understanding variability in disease severity and progression. Age and gender are two most basic epidemiological characteristics, yet their eff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1987aca2766d24aa930dbcfab0664fc
http://ora.ox.ac.uk/objects/uuid:a32f1b57-d07c-4253-b424-a9d2371999ad
http://ora.ox.ac.uk/objects/uuid:a32f1b57-d07c-4253-b424-a9d2371999ad
Publikováno v:
British Journal of Pharmacology. 121:361-368
1. Airway hyperresponsiveness in asthma has been ascribed to airway wall thickening as a result of smooth muscle proliferation and hypertrophy. We have previously shown that continuous exposure to the beta 2-adrenoceptor agonist, salbutamol inhibits
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6212b19845eff7047499fb0fc14d3966
https://doi.org/10.1038/sj.bjp.0701128
https://doi.org/10.1038/sj.bjp.0701128
Publikováno v:
British Journal of Pharmacology. 116:3219-3226
1. Airway smooth muscle proliferation is a significant component of the airway wall remodelling that occurs in asthma. In this study, the effects of glucocorticoids on mitogenic responses of human airway smooth muscle have been examined. 2. Pretreatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a08f08fb3cfeb3793f9352df1cccc1
https://doi.org/10.1111/j.1476-5381.1995.tb15127.x
https://doi.org/10.1111/j.1476-5381.1995.tb15127.x
Publikováno v:
Biochemical Pharmacology. 49:1809-1819
The link between increased usage of beta-adrenoceptor agonists and worsening of asthma symptoms has raised interest in the effects of agents such as salbutamol on airway wall remodelling, and particularly airway smooth muscle proliferation. In the pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3972bdd39d03b29274eed2ebe902c74d
https://doi.org/10.1016/0006-2952(94)00532-q
https://doi.org/10.1016/0006-2952(94)00532-q
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 12:110-119
Airway wall remodeling, including hyperplasia of airway smooth muscle, is regarded as an important contributor to airway hyperresponsiveness in asthmatic patients. The effects of the proinflammatory cytokine, tumor necrosis factor alpha (TNF alpha) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab58a04146232e0347c1cc84a09c965
https://doi.org/10.1165/ajrcmb.12.1.7529028
https://doi.org/10.1165/ajrcmb.12.1.7529028
Publikováno v:
Trends in Pharmacological Sciences. 14:275-279
The regulation of vascular smooth muscle proliferation has been examined extensively in recent years since the recognition that hyperplasia and hypertrophy of vascular smooth muscle are significant pathological features of hypertension and atheroscle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6aa4ee7763567026511e416540e5dab
https://doi.org/10.1016/0165-6147(93)90130-c
https://doi.org/10.1016/0165-6147(93)90130-c
Publikováno v:
Advances in Pharmacology ISBN: 9780120329342
Publisher Summary This chapter describes the evidence for airway wall remodeling in asthma, discusses the pathogenesis of these changes, and identify potential therapeutic approaches to arresting the remodeling process. There is a clear requirement f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb46f15ae955fb6faab602e78a842d6b
https://doi.org/10.1016/s1054-3589(08)60670-5
https://doi.org/10.1016/s1054-3589(08)60670-5