Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Paul R. Leger"'
Autor:
Jeffrey J. Jackson, Grant M. Shibuya, Buvana Ravishankar, Lavanya Adusumilli, Delia Bradford, Dirk G. Brockstedt, Cyril Bucher, Minna Bui, Cynthia Cho, Christoph Colas, Gene Cutler, Adrian Dukes, Xinping Han, Dennis X. Hu, Scott Jacobson, Paul D. Kassner, George E. Katibah, Michelle Yoo Min Ko, Urvi Kolhatkar, Paul R. Leger, Anqi Ma, Lisa Marshall, Jack Maung, Andrew A. Ng, Akinori Okano, Deepa Pookot, Daniel Poon, Chandru Ramana, Maureen K. Reilly, Omar Robles, Jacob B. Schwarz, Anton A. Shakhmin, Hunter P. Shunatona, Raashi Sreenivasan, Parcharee Tivitmahaisoon, Mengshu Xu, Thant Zaw, David J. Wustrow, Mikhail Zibinsky
Publikováno v:
Journal of Medicinal Chemistry. 65:12895-12924
General control nonderepressible 2 (GCN2) protein kinase is a cellular stress sensor within the tumor microenvironment (TME), whose signaling cascade has been proposed to contribute to immune escape in tumors. Herein, we report the discovery of cell-
Autor:
Paul D. Kassner, Dirk G. Brockstedt, David Wustrow, Jacob Schwarz, Christophe Colas, Jack Maung, Akinori Okano, Xinping Han, Nathan Kozon, Delia Bradford, Lisa A. Marshall, Silpa Suthram, Kyle Young, Betty Abraham, Deepa Pookot, Niket Shah, Jerick Sanchez, Steve T. Wong, Scott Jacobson, Cynthia Cho, Payal Rana, Berenger Biannic, Dennis X. Hu, Paul R. Leger, Gene Cutler, Michael T. Sun, Yamini M. Ohol
Genes whose expression is significantly altered upon USP7 inhibitor treatment of H526 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f989ee2cc8256a47675f17613ed482
https://doi.org/10.1158/1535-7163.22518810
https://doi.org/10.1158/1535-7163.22518810
Autor:
Paul D. Kassner, Dirk G. Brockstedt, David Wustrow, Jacob Schwarz, Christophe Colas, Jack Maung, Akinori Okano, Xinping Han, Nathan Kozon, Delia Bradford, Lisa A. Marshall, Silpa Suthram, Kyle Young, Betty Abraham, Deepa Pookot, Niket Shah, Jerick Sanchez, Steve T. Wong, Scott Jacobson, Cynthia Cho, Payal Rana, Berenger Biannic, Dennis X. Hu, Paul R. Leger, Gene Cutler, Michael T. Sun, Yamini M. Ohol
The deubiquitinase USP7 regulates the levels of multiple proteins with roles in cancer progression and immune response. Thus, USP7 inhibition may decrease oncogene function, increase tumor suppressor function, and sensitize tumors to DNA-damaging age
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2553fdd80c98dcbf6dde06a2115d9b1f
https://doi.org/10.1158/1535-7163.c.6542127.v1
https://doi.org/10.1158/1535-7163.c.6542127.v1
Autor:
Paul D. Kassner, Dirk G. Brockstedt, David Wustrow, Jacob Schwarz, Christophe Colas, Jack Maung, Akinori Okano, Xinping Han, Nathan Kozon, Delia Bradford, Lisa A. Marshall, Silpa Suthram, Kyle Young, Betty Abraham, Deepa Pookot, Niket Shah, Jerick Sanchez, Steve T. Wong, Scott Jacobson, Cynthia Cho, Payal Rana, Berenger Biannic, Dennis X. Hu, Paul R. Leger, Gene Cutler, Michael T. Sun, Yamini M. Ohol
Gene sets significantly upregulated upon USP7 inhibitor treatment of H526 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::533cabf48658430126efa2dc00097d50
https://doi.org/10.1158/1535-7163.22518813
https://doi.org/10.1158/1535-7163.22518813
Autor:
Paul D. Kassner, Dirk G. Brockstedt, David Wustrow, Jacob Schwarz, Christophe Colas, Jack Maung, Akinori Okano, Xinping Han, Nathan Kozon, Delia Bradford, Lisa A. Marshall, Silpa Suthram, Kyle Young, Betty Abraham, Deepa Pookot, Niket Shah, Jerick Sanchez, Steve T. Wong, Scott Jacobson, Cynthia Cho, Payal Rana, Berenger Biannic, Dennis X. Hu, Paul R. Leger, Gene Cutler, Michael T. Sun, Yamini M. Ohol
Supplementary Figures S1-S6 and legends, and Tables S1, S2, S5, S6, S7.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::608a87c8b9624888e8b1c3a5ac3f572b
https://doi.org/10.1158/1535-7163.22518816.v1
https://doi.org/10.1158/1535-7163.22518816.v1
Publikováno v:
J Am Chem Soc
Journal of the American Chemical Society, vol 142, iss 36
Journal of the American Chemical Society, vol 142, iss 36
The rearrangement of carbon-carbon (C-C) single bonds in readily available carbocyclic scaffolds can yield uniquely substituted carbocycles that would be challenging to construct otherwise. This is a powerful and often non-intuitive approach for comp
Autor:
Yamini M, Ohol, Michael T, Sun, Gene, Cutler, Paul R, Leger, Dennis X, Hu, Berenger, Biannic, Payal, Rana, Cynthia, Cho, Scott, Jacobson, Steve T, Wong, Jerick, Sanchez, Niket, Shah, Deepa, Pookot, Betty, Abraham, Kyle, Young, Silpa, Suthram, Lisa A, Marshall, Delia, Bradford, Nathan, Kozon, Xinping, Han, Akinori, Okano, Jack, Maung, Christophe, Colas, Jacob, Schwarz, David, Wustrow, Dirk G, Brockstedt, Paul D, Kassner
Publikováno v:
Molecular cancer therapeutics. 19(10)
The deubiquitinase USP7 regulates the levels of multiple proteins with roles in cancer progression and immune response. Thus, USP7 inhibition may decrease oncogene function, increase tumor suppressor function, and sensitize tumors to DNA-damaging age
Autor:
Raymond J. Andersen, Richmond Sarpong, Katherine Blackford, David E. Williams, Alexander Rode, Sonia Jancar, Victor M. Deflon, Roberto G. S. Berlinck, Juliana R. Gubiani, Yusuke Kuroda, Stanley Chang, Antonio G. Ferreira, Paul R. Leger, Nozomu Nagashima, Ildefonso Alves da Silva-Jr, Lara Durães Sette, Karen J. Nicacio
Publikováno v:
Nature Chemistry. 10:938-945
Studies of secondary metabolites (natural products) that cover their isolation, chemical synthesis and bioactivity investigation present myriad opportunities for discovery. For example, the isolation of novel secondary metabolites can inspire advance
Publikováno v:
Chemistry - A European Journal. 21:4377-4383
Progress toward the total syntheses of a diverse set of fawcettimine-type Lycopodium alkaloids via a "Heathcock-type" 6-5-9 tricycle is disclosed. This route features an intermolecular Diels-Alder cycloaddition to rapidly furnish the 6-5-fused bicycl
Publikováno v:
Tetrahedron Letters. 53:1772-1775
A novel methodology for facile production of α-cyano chalcones under microwave irradiation is described. Utilizing a Knoevenagel condensation between benzoylacetonitriles and aromatic aldehydes, substituted chalcones are generated via a 15-min, one-