Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Paul R. Kuefler"'
Autor:
Lina Asmar, Oluwatoyin O. Shonukan, Kristi J. McIntyre, Paul Conkling, Paul R. Kuefler, Mark Allen O'Rourke, Joyce O'Shaughnessy, Yanping Wang, Feng Zhan, Nicholas J. Robert
Publikováno v:
Breast Cancer Research and Treatment. 126:101-108
Palliation is the primary goal in metastatic breast cancer (MBC), and safe, efficacious, new single-agent options are needed. Pemetrexed, an antifolate, inhibits several folate-dependent enzymes involved in purine biosynthesis. The primary goal of th
Autor:
Carlos Becerra, Lalan S. Wilfong, Kristi A. Boehm, Scott P. Myrand, Donald A. Richards, Rebecca R. Hozak, Lina Asmar, John F. Gill, Luping Zhao, Feng Zhan, Steven J. Nicol, Paul R. Kuefler, Robert H. Gersh, Coleman K. Obasaju, Brian Mullaney
Publikováno v:
Investigational New Drugs. 29:144-153
Purpose Gemcitabine (G) is standard therapy for pancreatic cancer. Enzastaurin (E) inhibits PKCβ and PI3K/AKT signaling pathways with a dose-dependent effect on growth of pancreatic carcinoma xenografts. Data suggest that the GE combination may impr
Autor:
John E. Nugent, Robert L. Ruxer, Paul R. Kuefler, Kristi A. Boehm, Svetislava J. Vukelja, Donald A. Richards, Allen Lee Cohn, William J. Hyman, Maury Berger, Lina Asmar, Thomas H. Cartwright
Publikováno v:
Clinical Colorectal Cancer. 7:390-397
XELIRI (capecitabine/irinotecan) is effective and well tolerated in metastatic colorectal cancer (mCRC). Cetuximab is active in mCRC alone or with chemotherapy. This study evaluated cetuximab plus XELIRI in first-line treatment of mCRC.Subjects had h
Autor:
Oluwatoyin O. Shonukan, Paul Conkling, Yunfei Wang, Kristi McIntyre, Nicholas J. Robert, Joyce A. O'Shaughnessy, Paul R. Kuefler, Feng Zhan, Lina Asmar
Publikováno v:
Journal of Clinical Oncology. 26:1073-1073
1073 Background: Pemetrexed, a multitargeted antifolate, inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyl transferase (GARFT), a folate-dependent enzyme involved in purine synthesis. Inhibition
Autor:
Thomas H. Cartwright, Allen Lee Cohn, Kristi A. Boehm, William J. Hyman, Des Ilegbodu, M. Yoffe, Lina Asmar, Paul R. Kuefler
Publikováno v:
Journal of Clinical Oncology. 24:13502-13502
13502 Background: We have previously shown that capecitabine/irinotecan (XELIRI) is effective and well-tolerated in metastatic colorectal cancer (mCRC). Cetuximab targets EGFR and is active in mCRC either alone or combined with chemotherapy. This stu
Autor:
Paul A. Bunn, Paul R. Kuefler
Publikováno v:
Clinics in Haematology. 15:695-726
Adult T cell leukaemia/lymphoma was first identified by Japanese investigators in the mid 1970s. Distinctive characteristics include hypercalcaemia, metabolic bone disease, opportunistic infections and evidence of multiorgan involvement. The malignan
Publikováno v:
Thrombosis and Haemostasis. 30:531-540
SummaryThe effect of pharmacologic doses of adrenal corticosteroids upon plasma fibrinogen level, incorporation of 75Se-Methionine (75SeM) into fibrinogen, and disappearance of plasma 125I-fibrinogen was evaluated in rabbits. Single 25 mg doses of hy