Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Paul R. Heath"'
Autor:
Dana Saipiyeva, Manarbek Askarov, Nazanin Jafari, Rano Zhankina, Paul R. Heath, Larissa Kozina, Alyona Boltanova, Ardak Omarbekov, Nurbek Ilyassov, Turlybek Tuganbekov, Nadiar M. Mussin, Asset A. Kaliyev, Yerlan Sultangereyev, Farhad Rahmanifar, Mahdi Mahdipour, Shabnam Bakhshalizadeh, Reza Shirazi, Nader Tanideh, Amin Tamadon
Publikováno v:
Iranian Journal of Medical Sciences, Vol 49, Iss 9, Pp 559-572 (2024)
Background: Primary biliary cholangitis (PBC) is a condition affecting the liver and immune system. In this study, the impact of autologous bone marrow-derived mononuclear cell (BM-MNC) transplantation on PBC patients was investigated. Methods: Sixte
Externí odkaz:
https://doaj.org/article/d5aff479589f4c81ad8d0c9b99762944
Autor:
Norhayati Liaqat Ali Khan, Subhashini Muhandiram, Keerthie Dissanayake, Kasun Godakumara, Getnet Midekessa, Aneta Andronowska, Paul R. Heath, Suranga Kodithuwakku, Amber Rose Hart, Alireza Fazeli
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The growing understanding of the role of extracellular vesicles (EVs) in embryo-maternal communication has sparked considerable interest in their therapeutic potential within assisted reproductive technology, particularly in enhancing implantation su
Externí odkaz:
https://doaj.org/article/32c3493532d048b1bd37373f33f565e6
Autor:
Taghreed Almansouri, Rachel Waller, Stephen B. Wharton, Paul R. Heath, Fiona E. Matthews, Carol Brayne, Fredericus van Eeden, Julie E. Simpson
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4445 (2024)
Age-associated deep-subcortical white matter lesions (DSCLs) are an independent risk factor for dementia, displaying high levels of CD68+ microglia. This study aimed to characterize the transcriptomic profile of microglia in DSCLs and surrounding rad
Externí odkaz:
https://doaj.org/article/7019e6bec57849e29c4f012e6eb6ad7d
Autor:
Scott P. Allen, Afnan Al Sultan, Elaine Kabucho Kibirige, Erin Tonkiss, Keaton J. Hamer, Lydia M. Castelli, Ya-Hui Lin, Sarah Roscoe, Nikolaos Stefanidis, Richard J. Mead, J. Robin Highley, Johnathan Cooper-Knock, Guillaume M. Hautbergue, Paul R. Heath, Janine Kirby, Pamela J. Shaw
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
A p.Y374X truncation in TARDBP was recently shown to reduce expression of TDP43 in fibroblasts isolated from ALS cases. In this follow up study focused on assessing the downstream phenotypic consequences of loss of TDP43 in the context of the truncat
Externí odkaz:
https://doaj.org/article/ca2ad4e34a5b4061a9d5da2449950735
Autor:
Rohit Bazaz, Helen M. Marriott, Carl Wright, Janet Chamberlain, Laura E. West, Catherine Gelsthorpe, Paul R. Heath, Afsaneh Maleki-Dizaji, Sheila E. Francis, David H. Dockrell
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
IntroductionDespite epidemiological associations between community acquired pneumonia (CAP) and myocardial infarction, mechanisms that modify cardiovascular disease during CAP are not well defined. In particular, largely due to a lack of relevant exp
Externí odkaz:
https://doaj.org/article/6665aae7966b4665af002be385a30c39
Autor:
Lydia M. Castelli, Luisa Cutillo, Cleide Dos Santos Souza, Alvaro Sanchez-Martinez, Ilaria Granata, Ya-Hui Lin, Monika A. Myszczynska, Paul R. Heath, Matthew R. Livesey, Ke Ning, Mimoun Azzouz, Pamela J. Shaw, Mario R. Guarracino, Alexander J. Whitworth, Laura Ferraiuolo, Marta Milo, Guillaume M. Hautbergue
Publikováno v:
Molecular Neurodegeneration, Vol 16, Iss 1, Pp 1-24 (2021)
Abstract Background Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways hinders the identification of ALS-causing
Externí odkaz:
https://doaj.org/article/d1a033da7da847f699478c811b28f10b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6811 (2023)
One of the most critical steps in mammalian reproduction is implantation. Embryos with an impaired capacity for embryo–maternal crosstalk are thought to have a reduced potential for implantation. One agent of embryo–maternal communication is extr
Externí odkaz:
https://doaj.org/article/e6a761be0101484f9512aab0eeb77541
Autor:
Joanna J. Bury, Annabelle Chambers, Paul R. Heath, Paul G. Ince, Pamela J. Shaw, Fiona E. Matthews, Carol Brayne, Julie E. Simpson, Stephen B. Wharton, the Cognitive Function and Ageing Study
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-16 (2021)
Abstract Type 2 diabetes mellitus (T2D), characterised by peripheral insulin resistance, is a risk factor for dementia. In addition to its contribution to small and large vessel disease, T2D may directly damage cells of the brain neurovascular unit.
Externí odkaz:
https://doaj.org/article/81434b311ed04451bc4e6dc883799b2d
Autor:
Lucy Crooks, Johnathan Cooper-Knock, Paul R. Heath, Ahmed Bouhouche, Mostafa Elfahime, Mimoun Azzouz, Youssef Bakri, Mohammed Adnaoui, Azeddine Ibrahimi, Saaïd Amzazi, Rachid Tazi-Ahnini
Publikováno v:
BMC Genetics, Vol 21, Iss 1, Pp 1-8 (2020)
Abstract Background Large-scale human sequencing projects have described around a hundred-million single nucleotide variants (SNVs). These studies have predominately involved individuals with European ancestry despite the fact that genetic diversity
Externí odkaz:
https://doaj.org/article/c3092935033c4ed3986098cac62601f5
Autor:
Joanne Lacey, Simon J. Webster, Paul R. Heath, Chris J. Hill, Lucinda Nicholson-Goult, Bart E. Wagner, Abdullah O. Khan, Neil V. Morgan, Michael Makris, Martina E. Daly
Publikováno v:
Haematologica, Vol 107, Iss 8 (2022)
Germline defects affecting the DNA-binding domain of the transcription factor FLI1 are associated with a bleeding disorder that is characterized by the presence of large, fused α-granules in platelets. We investigated whether the genes showing abnor
Externí odkaz:
https://doaj.org/article/5e8049395ae1492595e078a91e38c33b