Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Paul R. Hartig"'
Autor:
Frank Yocca, Carlos M. Villalon, Andrew Sleight, Trevor Sharp, Pramod R. Saxena, Bryan Roth, John A. Peters, Stephen J. Peroutka, John Neumaier, Ewan Mylecharane, Derek N. Middlemiss, Graeme R. Martin, Luc Maroteaux, Klaus Peter Latté, Patrick P. A. Humphrey, Daniel Hoyer, Rebecca Hills, Katharine Herrick-Davis, Julie Hensler, René Hen, Paul R. Hartig, Michel Hamon, Mark Hamblin, Manfred Göthert, Richard M. Eglen, Aline Dumuis, Marlene L. Cohen, Amy Butler, Theresa Branchek, Joel Bockaert, Gordon Baxter, Nicholas M. Barnes, Rodrigo Andrade
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2023
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [198] and subsequently revised [180]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4af4d3d745f0e8e57bd57986ad25334a
https://doi.org/10.2218/gtopdb/f1/2023.1
https://doi.org/10.2218/gtopdb/f1/2023.1
Autor:
Pramod R. Saxena, Patrick P.A. Humphrey, Joël Bockaert, Rebecca Hills, Sleight Andrew, Rodrigo Andrade, Amy S. Butler, Bryan L. Roth, Graeme R. Martin, Frank D. Yocca, Stephen J. Peroutka, Manfred Göthert, Julie Hensler, Carlos M. Villalón, Katharine Herrick-Davis, Luc Maroteaux, Richard M. Eglen, Paul R. Hartig, Nicholas M. Barnes, M. Hamon, Theresa Branchek, Aline Dumuis, Klaus Peter Latté, Mark W. Hamblin, Trevor Sharp, Ewan J. Mylecharane, John F. Neumaier, René Hen, John A. Peters, Marlene L. Cohen, Derek N. Middlemiss, Gordon Baxter, Daniel Hoyer
Publikováno v:
IUPHAR/BPS Guide to Pharmacology CITE. 2019
5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [194] and subsequently revised [176]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::acc171822fcb3a73f3b0da9179a7a21b
https://doi.org/10.2218/gtopdb/f1/2019.4
https://doi.org/10.2218/gtopdb/f1/2019.4
Autor:
Lawrence W. Fitzgerald, Carol M. Krause, Anne P. Marshall, John P. Patterson, Deborah S. Conklin, Geeta Iyer, David P. Tran, Brian L. Largent, Paul R. Hartig, Walter A. Kostich
Publikováno v:
Journal of Neurochemistry. 72:2127-2134
Many modern models of receptor-G protein function assume that there is a direct relationship between high-affinity agonist binding and efficacy. The validity of this assumption has been recently questioned for the serotonin 5-HT2A receptor. We examin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::defe1bccc985bc020be71199c2f61751
https://doi.org/10.1046/j.1471-4159.1999.0722127.x
https://doi.org/10.1046/j.1471-4159.1999.0722127.x
Autor:
Argyrios G, Arvanitis, Joseph T, Rescinito, Charles R, Arnold, Richard G, Wilde, Gary A, Cain, Jung Hui, Sun, Jia-Sheng, Yan, Christopher A, Teleha, Lawrence W, Fitzgerald, John, McElroy, Robert, Zaczek, Paul R, Hartig, Scott, Grossman, Stephen P, Arneric, Paul J, Gilligan, Richard E, Olson, David W, Robertson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:125-128
A series of high affinity CRF receptor ligands with an imidazo[4,5-b]pyridine core is described. Individual analogues were synthesized and tested in a rat CRF receptor binding assay. The best compounds were further tested in the dog N-in-1 pharmacoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::057e389865579ec966662dc7ddd358a7
https://doi.org/10.1016/s0960-894x(02)00833-8
https://doi.org/10.1016/s0960-894x(02)00833-8
Publikováno v:
Journal of Neurochemistry. 64:199-205
The serotonin 5-HT 2C receptor (formerly designated the 5-HT 1C receptor) of the choroid plexus triggers phosphoinositide turnover. In the present study, we demonstrate that receptor activation also triggers the formation of cyclic GMP (cGMP). Applic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8f580957ec007165fad52c9639e9906
https://doi.org/10.1046/j.1471-4159.1995.64010199.x
https://doi.org/10.1046/j.1471-4159.1995.64010199.x
Autor:
Anne P. Marshall, Deborah S. Conklin, John P. Patterson, David P. Tran, Gerald J Jonak, Paul R. Hartig, Lawrence W. Fitzgerald, Carol M. Krause, Geeta Iyer
Publikováno v:
Neuropsychopharmacology. 21:82S-90S
RNA encoding the rat serotonin 5-HT2C receptor undergoes editing whereby one to four adenosines are converted to inosines. This conversion can change up to three codons out of a stretch of five in the second intracellular loop of the receptor. RNA ed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c2012d1d02c375502fabe70e3c05456
https://doi.org/10.1016/s0893-133x(99)00004-4
https://doi.org/10.1016/s0893-133x(99)00004-4
Autor:
Richard L. Weinshank, H T Kao, Theresa A. Branchek, D.A Urquhart, L E Schecter, Paul R. Hartig, Nika Adham, Margaret M. Durkin, M A Olsen, J. A. Bard
Publikováno v:
Proceedings of the National Academy of Sciences. 90:408-412
An intronless gene encoding an additional human serotonin (5-HT) 5-HT1-like receptor subtype was isolated from a human genomic library with probes obtained from degenerate PCR primers used to amplify 5-HT-receptor-specific sequences. The highest degr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b2fbeb2e439cb2594578a14bc308ba
https://doi.org/10.1073/pnas.90.2.408
https://doi.org/10.1073/pnas.90.2.408
Publikováno v:
Journal of Biological Chemistry. 267:21098-21104
cDNA clones encoding two novel gamma-aminobutyric acid (GABA) transporters (designated GAT-2 and GAT-3) have been isolated from rat brain, and their functional properties have been examined in mammalian cells. The transporters display high affinity f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d704786d40ac02f8a7bdceedbb631e6
https://doi.org/10.1016/s0021-9258(19)36802-4
https://doi.org/10.1016/s0021-9258(19)36802-4
Autor:
Richard L. Weinshank, Paul R. Hartig, Michael A. Olsen, Theresa Branchek, Hung-Teh Kao, Nika Adham
Publikováno v:
FEBS Letters. 307:324-328
Mesulergine displays approximately 50-fold higher affinity for the rat 5-HT2 receptor than for the human receptor. Comparison of the deduced amino acid sequences of cDNA clones encoding the human and rat 5-HT2 receptors reveals only 3 amino acid diff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a7d2da9a5cb1803d3533a35803bdf2
https://doi.org/10.1016/0014-5793(92)80705-l
https://doi.org/10.1016/0014-5793(92)80705-l
Publikováno v:
Neuron. 8:927-935
A complementary DNA clone encoding a transporter for glycine has been isolated from rat brain, and its functional properties have been examined in mammalian cells. The transporter displays high affinity for glycine (KM approximately 100 microM) and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9075e10e0c0ad45c5410199b827ce34c
https://doi.org/10.1016/0896-6273(92)90207-t
https://doi.org/10.1016/0896-6273(92)90207-t