Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation

Autor: Robert Little, Sathish K. Murali, Søren B. Poulsen, Paul R. Grimm, Adrienne Assmus, Lei Cheng, Jessica R. Ivy, Ewout J. Hoorn, Vladimir Matchkov, Paul A. Welling, Robert A. Fenton

Publikováno v: JCI Insight, Vol 8, Iss 5 (2023)

Dietary potassium (K+) supplementation is associated with a lowering effect in blood pressure (BP), but not all studies agree. Here, we examined the effects of short- and long-term K+ supplementation on BP in mice, whether differences depend on the a

Externí odkaz: https://doaj.org/article/981aeff09de14897ba5e01c62266c1c4

Identification and characterization of alternative STK39 transcripts within human and mouse kidneys reveals species‐specific regulation of blood pressure

Autor: Carlo J. Mercado, Xiaochun Wang, Paul R. Grimm, Paul A. Welling, Yen‐Pei C. Chang

Publikováno v: Physiological Reports, Vol 8, Iss 4, Pp n/a-n/a (2020)

Abstract STK39 encodes a serine threonine kinase, SPAK, which is part of a multi‐kinase network that determines renal Na+ reabsorption and blood pressure (BP) through regulation of sodium‐chloride co‐transporters in the kidney. Variants within

Externí odkaz: https://doaj.org/article/ff450af651f0486e945ff29349d152e1

Large-Scale Proteomic Assessment of Urinary Extracellular Vesicles Highlights Their Reliability in Reflecting Protein Changes in the Kidney

Autor: David H. Ellison, Xiao Tong Su, Paul A. Welling, Sathish K. Murali, Robert A. Fenton, Qi Wu, Eric Delpire, Paul R. Grimm, Søren Brandt Poulsen

Publikováno v: J Am Soc Nephrol
Wu, Q, Poulsen, S, Murali, S, Grimm, P R, Su, X-T, Delpire, E, Welling, P, Ellison, D & Fenton, R 2021, ' Large-Scale Proteomic Assessment of Urinary Extracellular Vesicles Highlights Their Reliability in Reflecting Protein Changes in the Kidney ', Journal of the American Society of Nephrology, vol. 32, no. 9, pp. 2195-2209 . https://doi.org/10.1681/ASN.2020071035

Background: Urinary extracellular vesicles (uEVs) are secreted into urine by cells from the kidneys and urinary tract. Although changes in uEV proteins are used for quantitative assessment of protein levels in the kidney or biomarker discovery, wheth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56ffd8ed54e1006fa4de40389c3f50f9
https://pubmed.ncbi.nlm.nih.gov/34230103

Paracrine Communication Links Sodium Chloride Cotransporter Activity in the Distal Convoluted Tubule to Remodeling of the Aldosterone‐Sensitive Distal Nephron

Autor: Paul R. Grimm, Eric Delpire, Ava Zapf, Paul A. Welling

Publikováno v: The FASEB Journal. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ee3ffe4b94496074f699fb2eb2b65c2
https://doi.org/10.1096/fasebj.2019.33.1_supplement.862.32

Inhibition of thiazide‐sensitive sodium chloride cotransporter phosphorylation provokes a global compensatory response (892.17)

Autor: James C. Wade, Paul A. Welling, Paul R. Grimm, Eric Delpire, Susan M. Wall

Publikováno v: The FASEB Journal. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::65aa100865b6103b822833c0349458f2
https://doi.org/10.1096/fasebj.28.1_supplement.892.17