Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Paul R. Gielen"'
Autor:
Barbara M Schulte, Paul R Gielen, Esther D Kers-Rebel, Gerty Schreibelt, Frank J M van Kuppeveld, Gosse J Adema
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0121670 (2015)
Enteroviruses often cause mild disease, yet are also linked to development of autoimmune diabetes. Dendritic cells (DCs) shape both innate and adaptive immune responses, including anti-viral responses. How different human DC subsets shape anti-viral
Externí odkaz:
https://doaj.org/article/35a2a9f8783047cfac97ad5199af7ea2
Autor:
Gosse J. Adema, Pieter Wesseling, Sandra A. J. F. H. Bossman, Barbara M. Schulte, Paul R. Gielen, Mark ter Laan, Kim C. M. Santegoets, Christian Büll, Esther D. Kers-Rebel, Benno Küsters
Publikováno v:
Cancer Immunology, Immunotherapy, 68(6), 937-949. Springer Science and Business Media Deutschland GmbH
Cancer Immunology, Immunotherapy
Cancer Immunology Immunotherapy, 68, 6, pp. 937-949
Santegoets, K C M, Gielen, P R, Büll, C, Schulte, B M, Kers-Rebel, E D, Küsters, B, Bossman, S A J F H, ter Laan, M, Wesseling, P & Adema, G J 2019, ' Expression profiling of immune inhibitory Siglecs and their ligands in patients with glioma ', Cancer Immunology, Immunotherapy, vol. 68, no. 6, pp. 937-949 . https://doi.org/10.1007/s00262-019-02332-w
Cancer Immunology Immunotherapy, 68, 937-949
Cancer Immunology, Immunotherapy
Cancer Immunology Immunotherapy, 68, 6, pp. 937-949
Santegoets, K C M, Gielen, P R, Büll, C, Schulte, B M, Kers-Rebel, E D, Küsters, B, Bossman, S A J F H, ter Laan, M, Wesseling, P & Adema, G J 2019, ' Expression profiling of immune inhibitory Siglecs and their ligands in patients with glioma ', Cancer Immunology, Immunotherapy, vol. 68, no. 6, pp. 937-949 . https://doi.org/10.1007/s00262-019-02332-w
Cancer Immunology Immunotherapy, 68, 937-949
Gliomas appear to be highly immunosuppressive tumors, with a strong myeloid component. This includes MDSCs, which are a heterogeneous, immature myeloid cell population expressing myeloid markers Siglec-3 (CD33) and CD11b and lacking markers of mature
Autor:
Paul R. Gielen, Jan W. A. Smit, Gosse J. Adema, Katrin Rabold, Romana T. Netea-Maier, Esther D. Kers-Rebel, Mihai G. Netea
Publikováno v:
Oncologist, 24, 3, pp. E106-E110
Oncologist, 24, E106-E110
Oncologist, 24, E106-E110
Background Aggressive forms of thyroid carcinoma (TC) show an abundant infiltration of immune cells, and this correlates with prognosis. However, little is known about circulating immune cell levels in advanced TC. Objective Investigate T-cell and my
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08988b1839e26f6015b36d3f5c5e5ee9
https://hdl.handle.net/2066/202146
https://hdl.handle.net/2066/202146
Autor:
Katharina Lind, Barbara M. Schulte, Paul R. Gielen, Esther D. Kers-Rebel, Gosse J. Adema, Cees J. Tack, Lammy D. Elving, Amy Prosser, Malin Flodström-Tullberg
Publikováno v:
Viral Immunology, 29, 7, pp. 389-97
Viral Immunology, 29, 389-97
Viral Immunology, 29, 389-97
Contains fulltext : 172472.pdf (Publisher’s version ) (Closed access) In children at risk for type 1 diabetes, innate immune activity is detected before seroconversion. Enterovirus infections have been linked to diabetes development, and a polymorp
Autor:
Gosse J. Adema, Mark ter Laan, Pieter Wesseling, Sandra A. J. F. H. Bossman, Barbara M Schulte, Kiek Verrijp, Esther D. Kers-Rebel, Paul R Gielen
Publikováno v:
Gielen, P R, Schulte, B M, Kers-Rebel, E D, Verrijp, K, Bossman, S A J F H, Ter Laan, M, Wesseling, P & Adema, G J 2016, ' Elevated levels of polymorphonuclear myeloid-derived suppressor cells in patients with glioblastoma highly express S100A8/9 and arginase and suppress T cell function ', Neuro-Oncology, vol. 18, no. 9, pp. 1253-64 . https://doi.org/10.1093/neuonc/now034
Neuro-Oncology, 18(9), 1253-64. Oxford University Press
Neuro-Oncology, 18, 9, pp. 1253-64
Neuro-Oncology, 18, 1253-64
Neuro-Oncology, 18(9), 1253. Oxford University Press
Neuro-Oncology, 18(9), 1253-64. Oxford University Press
Neuro-Oncology, 18, 9, pp. 1253-64
Neuro-Oncology, 18, 1253-64
Neuro-Oncology, 18(9), 1253. Oxford University Press
Contains fulltext : 167769.pdf (Publisher’s version ) (Closed access) BACKGROUND: Gliomas are primary brain tumors that are associated with a poor prognosis. The introduction of new treatment modalities (including immunotherapy) for these neoplasms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60090862d2b78c831cd7640746469450
https://doi.org/10.1093/neuonc/now034
https://doi.org/10.1093/neuonc/now034
Autor:
Paul R. Gielen, Melissa Wassink, Martijn H. den Brok, Peter M. Hoogerbrugge, Michiel Kroesen, Gosse J. Adema, Louis Boon, Inna Armandari, Christian Büll, Maaike W. G. Looman, Ingrid C. Brok
Publikováno v:
Oncoimmunology, 5, 6, pp. e1164919
Oncoimmunology
Oncoimmunology, 5, e1164919
Oncoimmunology
Oncoimmunology, 5, e1164919
Contains fulltext : 171471.pdf (Publisher’s version ) (Open Access) Neuroblastoma (NBL) is a childhood malignancy of the sympathetic nervous system. For high-risk NBL patients, the mortality rate is still over 50%, despite intensive multimodal trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e8e017b29146e05d025c33cefba38d3
https://hdl.handle.net/2066/171471
https://hdl.handle.net/2066/171471
Autor:
Harriëtte M.J.M. Petersen-Baltussen, Pieter Wesseling, Esther D. Kers-Rebel, Gosse J. Adema, Barbara M. Schulte, Paul R. Gielen, Mark ter Laan, Kiek Verrijp
Publikováno v:
Gielen, P R, Schulte, B M, Kers-Rebel, E D, Verrijp, K, Petersen-Baltussen, H M J M, Laan, M, Wesseling, P & Adema, G J 2015, ' Increase in Both CD14-Positive and CD15-Positive Myeloid-Derived Suppressor Cell Subpopulations in the Blood of Patients With Glioma But Predominance of CD15-Positive Myeloid-Derived Suppressor Cells in Glioma Tissue ', Journal of Neuropathology and Experimental Neurology, vol. 74, no. 5, pp. 390-400 . https://doi.org/10.1097/NEN.0000000000000183
Journal of Neuropathology and Experimental Neurology, 74, 390-400
Journal of Neuropathology and Experimental Neurology, 74, 5, pp. 390-400
Journal of Neuropathology and Experimental Neurology, 74(5), 390-400. Lippincott Williams and Wilkins
Journal of neuropathology & experimental neurology, 74(5), 390. Lippincott Williams and Wilkins
Journal of Neuropathology and Experimental Neurology, 74, 390-400
Journal of Neuropathology and Experimental Neurology, 74, 5, pp. 390-400
Journal of Neuropathology and Experimental Neurology, 74(5), 390-400. Lippincott Williams and Wilkins
Journal of neuropathology & experimental neurology, 74(5), 390. Lippincott Williams and Wilkins
Contains fulltext : 153143.pdf (Publisher’s version ) (Closed access) Myeloid-derived suppressor cells (MDSCs), defined as CD33-positive major histocompatibility complex class II-negative cells, are increased in a variety of human tumors and are as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b49ed0d35e8c05666b29ed1cde0500b
https://doi.org/10.1097/NEN.0000000000000183
https://doi.org/10.1097/NEN.0000000000000183
Autor:
Inna Armandari, Ingrid C. Brok, Michiel Kroesen, Peter M. Hoogerbrugge, Gosse J. Adema, Paul R. Gielen
Publikováno v:
Oncotarget
Oncotarget, 5, 6558-72
Oncotarget, 5, 16, pp. 6558-72
Oncotarget, 5, 6558-72
Oncotarget, 5, 16, pp. 6558-72
Item does not contain fulltext Epigenetic modifications, like histone acetylation, are essential for regulating gene expression within cells. Cancer cells acquire pathological epigenetic modifications resulting in gene expression patterns that facili
Publikováno v:
Neuroinflammation and CNS Disorders
Neuroinflammation and CNS Disorders, 363-384
STARTPAGE=363;ENDPAGE=384;TITLE=Neuroinflammation and CNS Disorders
Gielen, P, van der Valk, P & Wesseling, P 2014, Immune Responses to Tumours in the CNS . in Neuroinflammation and CNS Disorders . Wiley, pp. 363-384 . https://doi.org/10.1002/9781118406557.ch15
Neuroinflammation and CNS Disorders, 363-384
STARTPAGE=363;ENDPAGE=384;TITLE=Neuroinflammation and CNS Disorders
Gielen, P, van der Valk, P & Wesseling, P 2014, Immune Responses to Tumours in the CNS . in Neuroinflammation and CNS Disorders . Wiley, pp. 363-384 . https://doi.org/10.1002/9781118406557.ch15
After a brief introduction to the most frequent tumours of the central nervous system (CNS), the inflammatory responses in different CNS tumours will be described from a traditional neuropathologist's perspective. Subsequently, immunobiological aspec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee617b32b79c36263dfd0856fb777e87
https://doi.org/10.1002/9781118406557.ch15
https://doi.org/10.1002/9781118406557.ch15
Publikováno v:
Immunology, 138, 2, pp. 105-15
Immunology, 138, 105-15
Lindau, D, Gielen, P, Kroesen, M, Wesseling, P & Adema, G J 2013, ' The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells ', Immunology, vol. 138, no. 2, pp. 105-115 . https://doi.org/10.1111/imm.12036
Immunology, 138(2), 105-115. Wiley-Blackwell
Immunology, 138, 105-15
Lindau, D, Gielen, P, Kroesen, M, Wesseling, P & Adema, G J 2013, ' The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells ', Immunology, vol. 138, no. 2, pp. 105-115 . https://doi.org/10.1111/imm.12036
Immunology, 138(2), 105-115. Wiley-Blackwell
Item does not contain fulltext Myeloid-derived suppressor cells (MDSC) and regulatory T (Treg) cells are major components of the immune suppressive tumour microenvironment (TME). Both cell types expand systematically in preclinical tumour models and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e738bf3ed7ab12dc0d4c1bb05f20914
https://hdl.handle.net/2066/117802
https://hdl.handle.net/2066/117802