Výsledky vyhledávání - "Paul R. Fracasso"

Supplemental Materials and Methods, Supplementary Tables 1 through 3, Supplementary Figures 1 through 4 from BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110α and p110δ Activities in Tumor Cell Lines and Xenograft Models

Autor: Karl Ziegelbauer, Dominik Mumberg, William J. Scott, Scott M. Wilhelm, Martin Hentemann, Dean P. Wilkie, Paul R. Fracasso, Christoph A. Schatz, Andrea Haegebarth, Claudia Schneider, Cathy O. Bull, Bruce R. Rowley, Ningshu Liu

Supplementary Materials and Methods. Supplemental Table S1. Combination effects of BAY 80-6946 and lapatinib on caspase 9 activation in BT474 cells. Supplemental Table S2. Single dose i.v. pharmacokinetic parameter of BAY 80-6946 in female nude rats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1474ccb7f22408bd87b65c4e0d64c418
https://doi.org/10.1158/1535-7163.22498903.v1

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BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110α and p110δ Activities in Tumor Cell Lines and Xenograft Models

Autor: Andrea Haegebarth, William J. Scott, Claudia Schneider, Dean Wilkie, Scott Wilhelm, Paul R. Fracasso, Martin F. Hentemann, Cathy O. Bull, Dominik Mumberg, Ningshu Liu, Bruce R. Rowley, Karl Ziegelbauer, Christoph Schatz

Publikováno v: Molecular Cancer Therapeutics. 12:2319-2330

Because of the complexity derived from the existence of various phosphoinositide 3-kinase (PI3K) isoforms and their differential roles in cancers, development of PI3K inhibitors with differential pharmacologic and pharmacokinetic profiles would allow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1baba66783689d91aa015e38c9b206e
https://doi.org/10.1158/1535-7163.mct-12-0993-t

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