Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Paul R. Fatheree"'
Autor:
Whitney Krey-Epstein, Elad Kaufman, Erik Sandvik, Susan L. Calhoun, Paul R. Fatheree, Melanie A. Kleinschek, Joe Budman, Emma Gordon, Reuben Sana
Publikováno v:
Airway pharmacology and treatment.
Clinical studies with biologics have demonstrated the importance of cytokines in the pathobiology of asthma. However, redundancy and heterogeneity in the asthma cytokine networks may limit the efficacy of single cytokine-targeting biologics. Thus, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d512718c1b46176363dbb72f3bfe87f
https://doi.org/10.1183/13993003.congress-2019.pa3872
https://doi.org/10.1183/13993003.congress-2019.pa3872
Autor:
Craig M. Hill, Donavon McConn, Laxminarayan G Hegde, Roland Gendron, Brooke Blair, Keith Jendza, Joe Budman, Paul R. Fatheree, Daniel Marquess, R. Murray McKinnell, Cecile Yu, Sharath S. Hegde, Seok-Ki Choi, Uwe Klein
[Image: see text] Dual inhibition of angiotensin-converting enzyme (ACE) and neprilysin (NEP) by drugs such as omapatrilat produces superior antihypertensive efficacy relative to ACE inhibitors but is associated with a higher risk of life-threatening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ec5793446e9f5c0388334fd310b518
https://europepmc.org/articles/PMC6331171/
https://europepmc.org/articles/PMC6331171/
Autor:
Jeng-Pyng Shaw, Daniel Marquess, R. Murray McKinnell, Paul R. Fatheree, David Beattie, Scott R. Armstrong, Daniel D. Long, Ross G. Vickery
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4210-4215
The discovery of a series of 5-HT4 receptor agonists based on a novel 2-alkylbenzimidazole aromatic core is described. Optimization of the 2-substituent of the benzimidazole ring led to a series of agonists with subnanomolar binding affinity and mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0643983a830ed44b26b2d665107333f
https://doi.org/10.1016/j.bmcl.2013.05.018
https://doi.org/10.1016/j.bmcl.2013.05.018
Autor:
Roopa Rai, Kyle Elrod, William D. Shrader, James W. Janc, Yong Li, Lynne Cregar, Wendy B. Young, Aleksandr Kolesnikov, Thomas E. Jenkins, Paul R. Fatheree, Brad A. Katz, Erik Verner, Paul A. Sprengeler
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:710-713
Inhibition of coagulation proteases such as thrombin, fXa, and fVIIa has been a focus of ongoing research to produce safe and effective antithrombotic agents. Herein, we describe a unique zinc-mediated chelation strategy to streamline the discovery o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::890f430c3bb6f05e6bfb08f3695a2bf1
https://doi.org/10.1016/j.bmcl.2005.10.023
https://doi.org/10.1016/j.bmcl.2005.10.023
Autor:
Kevin M. Krause, Bettina Bazzini, J. Kevin Judice, Burton G. Christensen, Michael R. Leadbetter, Dane E. Karr, Sean G. Trapp, Elizabeth Soriano, Jeng-Pyng Shaw, Paul R. Fatheree, Kelly L. Quast, Lam Bernice M T, Martin S. Linsell, Matthew B. Nodwell, Terry X. Wu, John L. Pace, Jenny D. Villena, Stacy M. Adams
Publikováno v:
The Journal of Antibiotics. 57:326-336
Novel derivatives of N-decylaminoethylvancomycin (2), containing appended hydrophilic groups were synthesized and their antibacterial activity and ADME properties were evaluated. The compounds were prepared by reacting amines with the C-terminus (C-)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6222c56379e55f3952bdb5a808e761
https://doi.org/10.7164/antibiotics.57.326
https://doi.org/10.7164/antibiotics.57.326
Autor:
Paul R. Fatheree, Jacqueline A.M. Smith, Patrick P. Humphrey, David Beattie, S. Derek Turner, Seok-Ki Choi, Roland Gendron, Daniel Marquess, Goldblum Adam A, Ross G. Vickery, Jeng Pyng Shaw, Scott R. Armstrong, Daniel D. Long, Lan Jiang, Daniel Genov
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(19)
Utilization of Theravance’s multivalent approach to drug discovery towards 5-HT 4 receptor agonists with a focus on identification of neutral (non-charged at physiological pH) secondary binding groups is described. Optimization of a quinolone-tropa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98dc3bfd1562242be0ff583154f8c9fe
https://pubmed.ncbi.nlm.nih.gov/22959244
https://pubmed.ncbi.nlm.nih.gov/22959244
Autor:
David Beattie, Daniel D. Long, S. Derek Turner, Paul R. Fatheree, Jacqueline A.M. Smith, Scott R. Armstrong, Seok-Ki Choi, Roland Gendron, Jeng Pyng Shaw, Goldblum Adam A, Daniel Marquess, Ross G. Vickery, Patrick P. Humphrey
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(14)
Further application of our multivalent approach to drug discovery directed to 5-HT4 receptor agonists is described. Optimization of the linker and secondary binding amine in the indazole-tropane primary binding group series, for binding affinity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d91c6df1bb3ebe20770d405356021a
https://pubmed.ncbi.nlm.nih.gov/22683222
https://pubmed.ncbi.nlm.nih.gov/22683222
Autor:
Scott R. Armstrong, Seok-Ki Choi, Jeng-Pyng Shaw, David Beattie, Goldblum Adam A, S. Derek Turner, Daniel D. Long, R. Murray McKinnell, Ross G. Vickery, Daniel Marquess, Paul R. Fatheree, Jacqueline A.M. Smith, Roland Gendron, Patrick P. Humphrey
Publikováno v:
Journal of medicinal chemistry. 52(17)
5-HT(4) receptor agonists such as tegaserod have demonstrated efficacy in the treatment of constipation predominant irritable bowel syndrome (IBS-C), a highly prevalent disorder characterized by chronic constipation and impairment of intestinal propu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4688cb8658e9c717a833552ee059467
https://pubmed.ncbi.nlm.nih.gov/19663444
https://pubmed.ncbi.nlm.nih.gov/19663444
Autor:
Sharath S. Hegde, Matthew B. Nodwell, Martin S. Linsell, Kevin M. Krause, Paul R. Fatheree, Daniel Marquess, David W. Green, John L. Pace, James B. Aggen, Koné Kaniga, Sean G. Trapp, Jason P. Chinn, Seok-Ki Choi, J. Kevin Judice, Burton G. Christensen, Michael R. Leadbetter, S. Derek Turner, Daniel D. Long, Edmund J. Moran
Publikováno v:
The Journal of antibiotics. 61(10)
Further investigations towards novel glycopeptide/beta-lactam heterodimers are reported. Employing a multivalent approach to drug discovery, vancomycin and cephalosporin synthons, 4, 2, 5 and 10, 18, 25 respectively, were chemically linked to yield h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f61df8c63b20c8ea01fd57019b7448c
https://pubmed.ncbi.nlm.nih.gov/19168974
https://pubmed.ncbi.nlm.nih.gov/19168974
Autor:
R. Murray McKinnell, Scott R. Armstrong, David T. Beattie, Seok-Ki Choi, Paul R. Fatheree, Roland A. L. Gendron, Adam Goldblum, Patrick P. Humphrey, Daniel D. Long, Daniel G. Marquess, J. P. Shaw, Jacqueline A. M. Smith, S. Derek Turner, Ross G. Vickery
Publikováno v:
Journal of Medicinal Chemistry; Sep2009, Vol. 52 Issue 17, p5330-5343, 14p