Zobrazeno 1 - 10
of 252
pro vyhledávání: '"Paul R. Crocker"'
Autor:
Yaw-Wen Hsu, Fu-Fei Hsu, Ming-Tsai Chiang, Dong-Lin Tsai, Fu-An Li, Takashi Angata, Paul R. Crocker, Lee-Young Chau
Publikováno v:
Journal of Biomedical Science, Vol 28, Iss 1, Pp 1-15 (2021)
Abstract Background The accumulation of lipid-laden macrophages, foam cells, within sub-endothelial intima is a key feature of early atherosclerosis. Siglec-E, a mouse orthologue of human Siglec-9, is a sialic acid binding lectin predominantly expres
Externí odkaz:
https://doaj.org/article/2f0f3b273fa448dba3cf937927f8cb07
Autor:
Dimitra Lamprinaki, Pilar Garcia-Vello, Roberta Marchetti, Charlotte Hellmich, Kelli A. McCord, Kristian M. Bowles, Matthew S. Macauley, Alba Silipo, Cristina De Castro, Paul R. Crocker, Nathalie Juge
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Fusobacterium nucleatum is involved in the development of colorectal cancer (CRC) through innate immune cell modulation. However, the receptors of the interaction between F. nucleatum ssp. and immune cells remain largely undetermined. Here, we showed
Externí odkaz:
https://doaj.org/article/4819e070a92540a5acd7cd34751cb078
Autor:
Gavuthami Murugesan, Gang Wu, Manjula Nagala, Stuart M. Haslam, Alex McCraw, Paul R. Crocker, Anne Dell
Publikováno v:
Wellcome Open Research, Vol 6 (2021)
Background: Siglec-1 is a macrophage lectin-like receptor that mediates sialic acid-dependent cellular interactions. Its upregulation on macrophages in autoimmune disease was shown previously to promote inflammation through suppressing the expansion
Externí odkaz:
https://doaj.org/article/545e29dfd66b48a08a867f3648474800
Autor:
Cristina Di Carluccio, Rosa Ester Forgione, Marco Montefiori, Monica Civera, Sara Sattin, Giovanni Smaldone, K. Fukase, Y. Manabe, Paul R. Crocker, Antonio Molinaro, Roberta Marchetti, Alba Silipo
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101998- (2021)
Summary: Siglecs (sialic acid binding immunoglobulin (Ig)-like lectins) constitute a group of 15 human and 9 murine cell-surface transmembrane receptors belonging to the I-type lectin family, mostly expressed on innate immune cells and characterized
Externí odkaz:
https://doaj.org/article/a235801d51084937ad1d3362512574e7
Autor:
Susana Benet, Cristina Gálvez, Francis Drobniewski, Irina Kontsevaya, Lilibeth Arias, Marta Monguió‐Tortajada, Itziar Erkizia, Victor Urrea, Ruo‐Yan Ong, Marina Luquin, Maeva Dupont, Jakub Chojnacki, Judith Dalmau, Paula Cardona, Olivier Neyrolles, Geanncarlo Lugo‐Villarino, Christel Vérollet, Esther Julián, Hansjakob Furrer, Huldrych F. Günthard, Paul R. Crocker, Gustavo Tapia, Francesc E. Borràs, Jacques Fellay, Paul J. McLaren, Amalio Telenti, Pere‐Joan Cardona, Bonaventura Clotet, Cristina Vilaplana, Javier Martinez‐Picado, Nuria Izquierdo‐Useros
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 3, Pp n/a-n/a (2021)
Abstract The identification of individuals with null alleles enables studying how the loss of gene function affects infection. We previously described a non‐functional variant in SIGLEC1, which encodes the myeloid‐cell receptor Siglec‐1/CD169 i
Externí odkaz:
https://doaj.org/article/e05bc9140fb041fdabbc667eb4e666c4
Autor:
Rosa Ester Forgione, Cristina Di Carluccio, Juan Guzmán-Caldentey, Rosa Gaglione, Filomena Battista, Fabrizio Chiodo, Yoshiyuki Manabe, Angela Arciello, Pompea Del Vecchio, Koichi Fukase, Antonio Molinaro, Sonsoles Martín-Santamaría, Paul R. Crocker, Roberta Marchetti, Alba Silipo
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101401- (2020)
Externí odkaz:
https://doaj.org/article/3596021819884a63bf3bfbe06448533c
Publikováno v:
Biomedicines, Vol 10, Iss 2, p 239 (2022)
Macrophages (MΦ) are highly heterogenous and versatile innate immune cells involved in homeostatic and immune responses. Activated MΦ can exist in two extreme phenotypes: pro-inflammatory (M1) MΦ and anti-inflammatory (M2) MΦ. These phenotypes ca
Externí odkaz:
https://doaj.org/article/c70f6aaf21454edf8eec055cbc14c474
Autor:
Dieke van Dinther, Henrike Veninga, Salvador Iborra, Ellen G.F. Borg, Leoni Hoogterp, Katarzyna Olesek, Marieke R. Beijer, Sjoerd T.T. Schetters, Hakan Kalay, Juan J. Garcia-Vallejo, Kees L. Franken, Lamin B. Cham, Karl S. Lang, Yvette van Kooyk, David Sancho, Paul R. Crocker, Joke M.M. den Haan
Publikováno v:
Cell Reports, Vol 22, Iss 6, Pp 1484-1495 (2018)
Summary: Splenic CD169+ macrophages are located in the marginal zone to efficiently capture blood-borne pathogens. Here, we investigate the requirements for the induction of CD8+ T cell responses by antigens (Ags) bound by CD169+ macrophages. Upon Ag
Externí odkaz:
https://doaj.org/article/84df6989ba8c45e3a1b26eff608999f9
Autor:
Manjula Nagala, Emma McKenzie, Hannah Richards, Ritu Sharma, Sarah Thomson, Pietro Mastroeni, Paul R. Crocker
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
Siglec-E is a murine CD33-related siglec that functions as an inhibitory receptor and is expressed mainly on neutrophils and macrophage populations. Recent studies have suggested that siglec-E is an important negative regulator of lipopolysaccharide
Externí odkaz:
https://doaj.org/article/c77e1c4fe3b74d7c8a4181455dee7adf
Publikováno v:
Neurobiology of Disease, Vol 25, Iss 1, Pp 105-111 (2007)
PLP overexpressing mice display demyelination and axonopathic changes, accompanied by an elevation of CD8+ T-lymphocytes and CD11b+ macrophages in the CNS. By crossbreeding these mutants with RAG-1-deficient mice lacking mature lymphocytes, we could
Externí odkaz:
https://doaj.org/article/8f3fe5fce09246568b063e31fc0816d9