Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Paul R. Carey"'
Autor:
Marianne Pusztai-Carey, Paul R. Carey
Publikováno v:
Journal of Raman Spectroscopy. 52:2550-2556
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94fbf905ede9edb7bdfa07ff59c15763
https://doi.org/10.1002/jrs.6170
https://doi.org/10.1002/jrs.6170
Autor:
Paul R. Carey
The design and production of novel peptides and proteins occupy pivotal positions in science and technology and will continue to do so in the 21st century. Protein Engineering and Design outlines the rapid advances in computer-based modeling, protein
Autor:
Michael J. Yoon, Grant R. Whitmer, Hossein Heidari-Torkabadi, Michael N. Lombardo, Tao Che, Paul R. Carey, Marianne Pusztai-Carey
Publikováno v:
The Journal of Physical Chemistry B. 122:6377-6385
Raman difference spectroscopy is shown to provide a wealth of molecular detail on changes within bacterial cells caused by infusion of antibiotics or hydrogen peroxide. Escherichia coli strains paired with chloramphenicol, dihydrofolate reductase pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2faf14a29d4a70d717c37a0c3df15e45
https://doi.org/10.1021/acs.jpcb.8b03279
https://doi.org/10.1021/acs.jpcb.8b03279
Autor:
Blake R. Gibson, Grant R. Whitmer, Sean T. Weaver, Hossein Heidari-Torkabadi, Jordan F. Gibson, Michael Greenberg, Marianne Pusztai-Carey, Paul R. Carey
Publikováno v:
Biochemistry. 56:2247-2250
Two protocols that allow for the comparison of Raman spectra of planktonic cells and biofilm formed from these cells in their growth phase have been developed. Planktonic cells are washed and flash-frozen in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01205f6d33883039016cc86122c10d7
https://doi.org/10.1021/acs.biochem.7b00116
https://doi.org/10.1021/acs.biochem.7b00116
Autor:
Shuangluo Xia, Thomas D. Christian, Paul R. Carey, William H. Konigsberg, Ioanna H. Antonopoulos
Publikováno v:
Journal of Raman Spectroscopy. 47:110-115
Raman difference spectroscopy is used to monitor the conformational changes associated with dNMP incorporation in single crystals of a RB69 DNA polymerase (RB69pol) ternary complex. An inactive crystal of L415G RB69pol exo- with a primer/template dup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b47491ac18606c6023a1b2373a229022
https://doi.org/10.1002/jrs.4846
https://doi.org/10.1002/jrs.4846
Publikováno v:
Annals of the New York Academy of Sciences. 1354:67-81
Raman spectroscopy can play a role in both antibiotic discovery and understanding the molecular basis of resistance. A major challenge in drug development is to measure the population of the drug molecules inside a cell line and to follow the chemist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::617a5001bf746135c1808b075f99bb71
https://doi.org/10.1111/nyas.12847
https://doi.org/10.1111/nyas.12847
Autor:
Hossein Heidari-Torkabadi, Amy C. Anderson, Michael N. Lombardo, Paul R. Carey, Dennis L. Wright, Tao Che
Publikováno v:
Biochemistry. 54:2719-2726
We report the first Raman spectroscopic study of propargyl-linked dihydrofolate reductase (DHFR) inhibitors being taken up by wild type Escherichia coli, Klebsiella pneumoniae, and Staphylococcus aureus cells. A novel protocol is developed where cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::617e430077ed81ccec570067fabb5d30
https://doi.org/10.1021/acs.biochem.5b00202
https://doi.org/10.1021/acs.biochem.5b00202
Autor:
Tao Che, Paul R. Carey, Focco van den Akker, John D. Buynak, Marianne Pusztai-Carey, Sivaprakash Shanmugam, Robert A. Bonomo, Christopher R. Bethel, Weirui Chai, Zhe Ding, Michael D. Nottingham, Elizabeth A. Rodkey
Publikováno v:
Biochemistry
For the class A β-lactamase SHV-1, the kinetic and mechanistic properties of the clinically used inhibitor sulbactam are compared with the sulbactam analog substituted in its 6β position by a CH2OH group (6β-(hydroxymethyl)penicillanic acid). The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4f3ff6c817a150eb2f1a4e57c28482
https://doi.org/10.1021/bi501197t
https://doi.org/10.1021/bi501197t
Autor:
Focco van den Akker, Elizabeth A. Rodkey, John D. Buynak, Weirui Chai, Kerri M. Smith, Tao Che, Christopher R. Bethel, Yan Xu, Paul R. Carey, Robert A. Bonomo, David C. McLeod
Publikováno v:
Journal of the American Chemical Society. 135:18358-18369
The inhibition of the class A SHV-1 β-lactamase by 7-(tert-butoxycarbonyl)methylidenecephalosporin sulfone was examined kinetically, spectroscopically, and crystallographically. An 1.14 Å X-ray crystal structure shows that the stable acyl-enzyme, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2fe61d0b477b3f852879d1a0e32c53
https://doi.org/10.1021/ja403598g
https://doi.org/10.1021/ja403598g
Publikováno v:
Biochemistry. 52:4881-4890
Y-Family DNA polymerases are known to bypass DNA lesions in vitro and in vivo. Sulfolobus solfataricus DNA polymerase (Dpo4) was chosen as a model Y-family enzyme for investigating the mechanism of DNA synthesis in single crystals. Crystals of Dpo4 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b72101f153643f8a3b0c852ae0f9ebe
https://doi.org/10.1021/bi400524h
https://doi.org/10.1021/bi400524h